Evgenia Gerasimovskaya, PhD
Associate Professor, Pediatrics-Critical Care Medicine

Research Interests

Publications

• Fini MA, Monks JA, Li M, Gerasimovskaya E, Paucek P, Wang K, Frid MG, Pugliese SC, Bratton D, Yu YR, Irwin D, Karin M, Wright RM, Stenmark KR. Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration. bioRxiv. 2023 Jul 21. PubMed PMID: 37502951
• Zhang H, Gerasimovskaya E, McCarthy MK, May NA, Prasad RR, Riddle S, McKeon BA, Kumar S, Li M, Hu CJ, Frid MG, Morrison TE, Stenmark KR. Local Complement Contributes to Pathogenic Activation of Lung Endothelial Cells in SARS-CoV-2 Infection. Am J Respir Cell Mol Biol. 2023 Aug;69(2):210-219. PubMed PMID: 37071849
• Zhang H, D'Alessandro A, Li M, Reisz JA, Riddle S, Muralidhar A, Bull T, Zhao L, Gerasimovskaya E, Stenmark KR. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension. Vascul Pharmacol. 2023 Apr;149:107157. PubMed PMID: 36849042
• Burns N, Nijmeh H, Lapel M, Riddle S, Yegutkin GG, Stenmark KR, Gerasimovskaya E. Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology research. Microvasc Res. 2023 May;147:104479. PubMed PMID: 36690271
• Hui Zhang, Evgenia Gerasimovskaya, Mary K. McCarthy, Nicholas A. May, Riddle, Suzette, B. Alexandre McKeon, Ram Raj Prasad, Cheng-Jun Hu, Thomas E. Morrison, Kurt R. Stenmark "Local complement contributes to pathogenic activation of lung endothelial cells in SARS-CoV-2" American Journal of Respiratory Cell and Molecular Biology (ATS abstract)
• Parinandi N, Gerasimovskaya E, Verin A. Editorial: Molecular mechanisms of lung endothelial permeability. Front Physiol. 2022;13:976873. PubMed PMID: 35936898
• Alexander Verin, Liselle Simon, Mary Cherian-Shaw, Derek Strassheim, Vijaya Karoor, Cheng-Jun Hu, Kurt R. Stenmark, Evgenia Gerasimovskaya "Short-chain fatty acid butyrate promotes vasa vasorum endothelial cell barrier protection: potential role of epigenetic and signaling mechanisms"
• Fini Mehdi, Petr Paucek, Angelo D’Alessandro, Julie Haines, Philip Weston, Kurt R. Stenmark, Evgenia Gerasimovskaya "Short-chain fatty acid butyrate is a metabolic and bioenergetic regulator of pulmonary artery vasa vasorum endothelial cells" Fini Mehdi, Petr Paucek, Angelo D’Alessandro, Julie Haines, Philip Weston, Kurt R. Stenmark, Evgenia Gerasimovskaya
• Stenmark KR, Frid MG, Gerasimovskaya E, Zhang H, McCarthy MK, Thurman JM, Morrison TE. Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement. Pulm Circ. 2021 Apr-Jun;11(2):20458940211015799. PubMed PMID: 34046161
• Karoor V, Strassheim D, Sullivan T, Verin A, Umapathy NS, Dempsey EC, Frank DN, Stenmark KR, Gerasimovskaya E. The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension. Int J Mol Sci. 2021 Sep 14;22(18). PubMed PMID: 34576081
• Derek Strassheim, Timothy Sullivan, David C. Irwin, Evgenia Gerasimovskaya, Tim Lahm, Dwight J. Klemm, Edward C. Dempsey, Kurt R. Stenmark, and Vijaya Karoor. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells 2021, 10, 3347
• Vijaya Karoor, Derek Strassheim, Robert Batori, Anita Kovacs-Kasa, Timothy Sullivan, Radu Moldovan, Dwight Klemm, Kurt R Stenmark, Alexander Verin, and Evgenia Gerasimovskaya HDAC Inhibitor Butyrate Cooperates with A1 and A2B Receptors to Attenuate Pulmonary Artery Vasa Vasorum Dysfunction in Hypoxia
• Strassheim D, Verin A, Batori R, Nijmeh H, Burns N, Kovacs-Kasa A, Umapathy NS, Kotamarthi J, Gokhale YS, Karoor V, Stenmark KR, Gerasimovskaya E. P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases. Int J Mol Sci. 2020 Sep 18;21(18). PubMed PMID: 32962005
• Verin AD, Batori R, Kovacs-Kasa A, Cherian-Shaw M, Kumar S, Czikora I, Karoor V, Strassheim D, Stenmark KR, Gerasimovskaya EV. Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms. Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C183-C193. PubMed PMID: 32432925
• Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020 Feb 11;9(2). PubMed PMID: 32054096
• Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC. Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):154-163. PubMed PMID: 29191928
• Lapel M, Weston P, Strassheim D, Karoor V, Burns N, Lyubchenko T, Paucek P, Stenmark KR, Gerasimovskaya EV. Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C56-C70. PubMed PMID: 27856430
• Lapel M, Weston P, Strassheim D, Karoor V, Burns N, Lyubchenko T, Paucek P, Stenmark KR, Gerasimovskaya EV. Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C56-C70. PubMed PMID: 27856430
• Nijmeh H, Balasubramaniam V, Burns N, Ahmad A, Stenmark KR, Gerasimovskaya EV. High proliferative potential endothelial colony forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 7. [Epub ahead of print] PubMed PMID: 24508729
• Nijmeh H, Balasubramaniam V, Burns N, Ahmad A, Stenmark KR, Gerasimovskaya EV. High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L661-71. PubMed PMID: 24508729
• Umapathy SN, Kaczmarek E, Fatteh N, Burns N, Lucas R, Stenmark KR, Verin AD, Gerasimovskaya EV. Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. PLoS One. 2013;8(4):e59733. PubMed PMID: 23613714
• Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013;75:23-47. PubMed PMID: 23216413
• Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The Adventitia: Essential Regulator of Vascular Wall Structure and Function. Annu Rev Physiol. 2012 Dec 3. [Epub ahead of print] PubMed PMID: 23216413
• Gerasimovskaya E, Kratzer A, Sidiakova A, Salys J, Zamora M, Taraseviciene-Stewart L. Interplay of macrophages and T cells in the lung vasculature. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1014-22. PubMed PMID: 22387295
• Anwar A, Li M, Frid MG, Kumar B, Gerasimovskaya EV, Riddle SR, McKeon BA, Thukaram R, Meyrick BO, Fini MA, Stenmark KR. Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1;303(1):L1-L11. PubMed PMID: 22582113
• Nana Burns, Hala Nijmeh, Martin Lapel, Suzette Riddle, Gennady G. Yegutkin, Kurt R Stenmark, and Evgenia Gerasimovskaya* "Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: implementation to vascular biology research" Microvascular Research (in revision)
• Hui Zhang, Evgenia Gerasimovskaya, Mary K. McCarthy, Nicholas A. May, Riddle, Suzette, B. Alexandre McKeon, Ram Raj Prasad, Cheng-Jun Hu, Thomas E. Morrison, Kurt R. Stenmark "Local complement contributes to pathogenic activation of lung endothelial cells in SARS-CoV-2" American Journal of Respiratory Cell and Molecular Biology (in revision)
• Fini, M.A., Monks, J.A. Li, M., Gerasimovskaya, E., Paucek, P., Wang, K., Frid, M.G., Pugliese, S.C., Bratton, D., Janssen, W., Scarpulla, R., Karin, M., Wright, R.M., Stenmark, K.R. Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration Cell Reports, 2022 (in revision)
• Angelo D’Alessandro, Hui Zhang, Min Li, Julie A. Reisz, Sarah Gehrke, Suzette Riddle, Kenneth L. Jones,Chien-nien Chen, Akshay Muralidhar, Todd Bull, Karim C. El Kasmi, Evgenia Gerasimovskaya , Lan Zhao, Kurt R. Stenmark "Histone Deacetylase Inhibitors Synergize with Sildenafil to Suppress Purine Metabolism and Proliferation of Pulmonary Artery Fibroblasts of Hypertensive Patients" Vascular Pharmacology (in preparation)