Pei-Ni Jone, MD
Professor, Pediatrics-Cardiology

Photo
Medical School:
  • MD, Northwestern University The Feinberg School of Medicine (2001)
Undergraduate School:
  • BS, Northwestern University (IL) (1997)
Residency:
  • University of Minnesota Medical School Program, Pediatrics (2004)
Fellowships:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Pediatric Cardiology (2007)
Languages: English, Taiwanese, Mandarin
Department: Pediatrics-Cardiology

Professional Titles

  • Director of 3D Echocardiography
  • Director of Kawasaki Disease Clinic
  • Director of Quality in Echocardiography

Recognition & Awards

  • Fellow of American Heart Association, American Heart Association (2019)
  • Fellow of American Society of Echocardiography, American Society of Echocardiography (2016)
  • Patient-Family Experience Excellence in Patient Care Award, Children's Hospital Colorado (2016)
  • Fellow of American College of Cardiology, American College of Cardiology (2016)

Research Interests

My research interests are in 3D Echocardiography, Kawasaki Disease, and Echocardiography in Pulmonary Hypertension.

Publications

  • Jone PN, Ivy DD, Daniels SR. Pediatric Cardiology: From Basics to Innovation. Pediatr Clin North Am. 2020 Oct;67(5):xvii-xviii. PubMed PMID: 32888696
  • Friedman KG, Jone PN. Update on the Management of Kawasaki Disease. Pediatr Clin North Am. 2020 Oct;67(5):811-819. PubMed PMID: 32888683
  • McCrindle BW, Manlhiot C, Newburger JW, Harahsheh AS, Giglia TM, Dallaire F, Friedman K, Low T, Runeckles K, Mathew M, Mackie AS, Choueiter NF, Jone PN, Kutty S, Yetman AT, Raghuveer G, Pahl E, Norozi K, McHugh KE, Li JS, De Ferranti SD, Dahdah N. Medium-Term Complications Associated With Coronary Artery Aneurysms After Kawasaki Disease: A Study From the International Kawasaki Disease Registry. J Am Heart Assoc. 2020 Aug 4;9(15):e016440. PubMed PMID: 32750313
  • Jone PN, Korst A, Karimpour-Fard A, Thomas T, Dominguez SR, Heizer H, Anderson MS, Glode MP, Sucharov CC, Miyamoto SD. Circulating microRNAs differentiate Kawasaki Disease from infectious febrile illnesses in childhood. J Mol Cell Cardiol. 2020 Sep;146:12-18. PubMed PMID: 32634388
  • Jone PN. Applications of three-dimensional transesophageal echocardiography in congenital heart disease. Echocardiography. 2020 Jun 28. [Epub ahead of print] PubMed PMID: 32594626
  • Jone PN, Sandoval JP, Haak A, Hammers J, Rodriguez-Zanella H, Quaife RA, Salcedo EE, Carroll JD, Gill E. Echocardiography-fluoroscopy fusion imaging: The essential features used in congenital and structural heart disease interventional guidance. Echocardiography. 2020 May;37(5):769-780. PubMed PMID: 32338402
  • Frank BS, Schafer M, Thomas TM, Haxel C, Ivy DD, Jone PN. Right Atrial Conduit Phase Emptying Predicts Risk of Adverse Events in Pediatric Pulmonary Arterial Hypertension. J Am Soc Echocardiogr. 2020 Aug;33(8):1006-1013. PubMed PMID: 32336608
  • Hao S, Ling XB, Kanegaye JT, Bainto E, Dominguez SR, Heizer H, Jone PN, Anderson MS, Jaggi P, Baker A, Son MB, Newburger JW, Ashouri N, McElhinney DB, Burns JC, Whitin JC, Cohen HJ, Tremoulet AH. Multicentre validation of a computer-based tool for differentiation of acute Kawasaki disease from clinically similar febrile illnesses. Arch Dis Child. 2020 Aug;105(8):772-777. PubMed PMID: 32139365
  • DeVore GR, Haxel C, Satou G, Sklansky M, Pelka MJ, Jone PN, Cuneo BF. Improved detection of coarctation of the aorta using speckle tracking analysis of the fetal heart using the last examination prior to delivery. Ultrasound Obstet Gynecol. 2020 Feb 5. [Epub ahead of print] PubMed PMID: 32022339
  • Teitel DF, Newburger JW, Sutton N, Tani LY, Harahsheh AS, Jone PN, Mensch DJ, Cotts T, Davidson A, Dahdah N, Johnson WH Jr, Portman MA. Development and Utility of Quality Metrics for Ambulatory Pediatric Cardiology in Kawasaki Disease. Clin Pediatr (Phila). 2020 Mar;59(3):245-251. PubMed PMID: 31896280
  • Truong U, Meinel K, Haddad F, Koestenberger M, Carlsen J, Ivy D, Jone PN. Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension. Cardiovasc Diagn Ther. 2020 Oct;10(5):1604-1624. PubMed PMID: 33224776
  • Jone PN, Duchateau N, Pan Z, Ivy DD, Moceri P. Right ventricular area strain from 3-dimensional echocardiography: Mechanistic insight of right ventricular dysfunction in pediatric pulmonary hypertension. J Heart Lung Transplant. 2020 Nov 15. [Epub ahead of print] PubMed PMID: 33268039
  • Jone PN, Haak A, Ross M, Wiktor DM, Gill E, Quaife RA, Messenger JC, Salcedo EE, Carroll JD. Congenital and Structural Heart Disease Interventions Using Echocardiography-Fluoroscopy Fusion Imaging. J Am Soc Echocardiogr. 2019 Oct 6. [Epub ahead of print] PubMed PMID: 31597599
  • Tremoulet AH, Jain S, Jone PN, Best BM, Duxbury EH, Franco A, Printz B, Dominguez SR, Heizer H, Anderson MS, Glodé MP, He F, Padilla RL, Shimizu C, Bainto E, Pancheri J, Cohen HJ, Whitin JC, Burns JC. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm. J Pediatr. 2019 Sep 24. [Epub ahead of print] PubMed PMID: 31561960
  • Dominguez SR, Birkholz M, Anderson MS, Heizer H, Jone PN, Glode MP, Todd JK. Diagnostic and Treatment Trends in Children With Kawasaki Disease in the United States, 2006-2015. Pediatr Infect Dis J. 2019 Oct;38(10):1010-1014. PubMed PMID: 31365480
  • DeVore GR, Jone PN, Satou G, Sklansky M, Cuneo BF. Aortic Coarctation: A Comprehensive Analysis of Shape, Size, and Contractility of the Fetal Heart. Fetal Diagn Ther. 2019 May 27;:1-11. [Epub ahead of print] PubMed PMID: 31132773
  • McLennan D, Góreczny S, Jone PN, Haak A, Morgan GJ. Left ventricular outflow tract pseudoaneurysm occlusion with fusion of live 3-dimensional transesophageal echocardiography and fluoroscopy. Kardiol Pol. 2019 Jun 25;77(6):647-648. PubMed PMID: 31124541
  • Kiely DG, Levin D, Hassoun P, Ivy DD, Jone PN, Bwika J, Kawut SM, Lordan J, Lungu A, Mazurek J, Moledina S, Olschewski H, Peacock A, Puri GD, Rahaghi F, Schafer M, Schiebler M, Screaton N, Tawhai M, Van Beek EJ, Vonk-Noordegraaf A, Vanderpool RR, Wort J, Zhao L, Wild J, Vogel-Claussen J, Swift AJ. EXPRESS: Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI). Pulm Circ. 2019 Mar 18;:2045894019841990. [Epub ahead of print] PubMed PMID: 30880632
  • Watanabe K, Schäfer M, Cassidy C, Miyamoto SD, Jone PN. Right atrial function in pediatric heart transplant patients by echocardiographic strain measurements. Pediatr Transplant. 2019 May;23(3):e13383. PubMed PMID: 30866164
  • Roberts SC, Jain S, Tremoulet AH, Kim KK, Burns JC, Anand V, Anderson M, Ang J, Ansusinha E, Arditi M, Ashouri N, Bartlett A, Chatterjee A, DeBiasi R, Dekker C, DeZure C, Didion L, Dominguez S, El Feghaly R, Erdem G, Halasa N, Harahsheh A, Jackson MA, Jaggi P, Jain S, Jone PN, Kaushik N, Kurio G, Lillian A, Lloyd D, Manaloor J, McNelis A, Michalik DE, Newburger J, Newcomer C, Perkins T, Portman M, Romero J, Ronis T, Rowley A, Schneider K, Schuster J, Tejtel SKS, Sharma K, Simonsen K, Szmuszkovicz J, Truong D, Wood J, Yeh S. The Kawasaki Disease Comparative Effectiveness (KIDCARE) trial: A phase III, randomized trial of second intravenous immunoglobulin versus infliximab for resistant Kawasaki disease. Contemp Clin Trials. 2019 Apr;79:98-103. PubMed PMID: 30840903
  • Jone PN, Ivy DD. Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension. Curr Treat Options Cardiovasc Med. 2019 Feb 9;21(1):6. PubMed PMID: 30739224
  • Jone PN, Haak A, Petri N, Ross M, Morgan G, Wiktor DM, Gill E, Quaife RA, Messenger JC, Salcedo EE, Carroll JD. Echocardiography-Fluoroscopy Fusion Imaging for Guidance of Congenital and Structural Heart Disease Interventions. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1279-1282. PubMed PMID: 30660524
  • Jone PN, Schäfer M, Pan Z, Ivy DD. Right Ventricular-Arterial Coupling Ratio Derived From 3-Dimensional Echocardiography Predicts Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Dec;12(1):e008176. PubMed PMID: 30632388
  • Ellis WC, Schafer M, Barrett CS, Butler K, Sprowell A, Twite M, Buckvold S, Jone PN, Ing RJ. Vascular anatomical considerations and clinical decision making during insertion of the Avalon(®) Elite Dual Lumen single-site veno-venous ECMO cannula in children weighing less than 20 kg. Perfusion. 2019 May;34(4):267-271. PubMed PMID: 30537888
  • Jone PN, Zablah JE, Burkett DA, Schäfer M, Wilson N, Morgan GJ, Ross M. Three-Dimensional Echocardiographic Guidance of Right Heart Catheterization Decreases Radiation Exposure in Atrial Septal Defect Closures. J Am Soc Echocardiogr. 2018 Sep;31(9):1044-1049. PubMed PMID: 29958759
  • Schäfer M, Truong U, Ivy DD, Fonseca B, Malone L, DiMaria M, Barker AJ, Vargas D, Hunter KS, Jone PN, Browne LP. Children with kawasaki disease present elevated stiffness of great arteries: Phase-contrast MRI study. J Magn Reson Imaging. 2018 Nov;48(5):1228-1236. PubMed PMID: 29707843
  • Cassidy C, Mitchell MB, Jone PN. Three-dimensional echocardiographic evaluation of Ebstein's anomaly of the tricuspid valve in a patient with hypoplastic left heart syndrome. Cardiol Young. 2018 Jun;28(6):885-887. PubMed PMID: 29679990
  • Jone PN, Anderson MS, Mulvahill MJ, Heizer H, Glodé MP, Dominguez SR. Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?. Pediatr Infect Dis J. 2018 Oct;37(10):976-980. PubMed PMID: 29461447
  • Jone PN, Gould R, Barrett C, Younoszai AK, Fonseca B. Data-Driven Quality Improvement Project to Increase the Value of the Congenital Echocardiographic Report. Pediatr Cardiol. 2018 Apr;39(4):726-730. PubMed PMID: 29350246
  • Jone PN, Khoo N. Innovation in 3D Echocardiographic Imaging. Curr Treat Options Cardiovasc Med. 2018 Jan 19;20(1):1. PubMed PMID: 29349638
  • Friesen RM, Schäfer M, Jone PN, Appiawiah N, Vargas D, Fonseca B, DiMaria MV, Truong U, Malone L, Browne LP. Myocardial Perfusion Reserve Index in Children With Kawasaki Disease. J Magn Reson Imaging. 2018 Jul;48(1):132-139. PubMed PMID: 29232024
  • Friesen RM, Schäfer M, Burkett DA, Cassidy CJ, Ivy DD, Jone PN. Right Ventricular Tissue Doppler Myocardial Performance Index in Children with Pulmonary Hypertension: Relation to Invasive Hemodynamics. Pediatr Cardiol. 2018 Jan;39(1):98-104. PubMed PMID: 28980052
  • Jone PN, Schäfer M, Pan Z, Bremen C, Ivy DD. 3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension. Eur Heart J Cardiovasc Imaging. 2018 Sep 1;19(9):1026-1033. PubMed PMID: 28950335
  • Friesen RM, Schäfer M, Burkett DA, Cassidy CJ, Ivy DD, Jone PN. Right Ventricular Tissue Doppler Myocardial Performance Index in Children with Pulmonary Hypertension: Relation to Invasive Hemodynamics. Pediatr Cardiol. 2017 Oct 4. [Epub ahead of print] PubMed PMID: 28980052
  • Jone PN, Schäfer M, Pan Z, Bremen C, Ivy DD. 3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension. Eur Heart J Cardiovasc Imaging. 2017 Aug 25. [Epub ahead of print] PubMed PMID: 28950335
  • Cortez D, Sharma N, Jone PN. Atrioventricular depolarization differences identify coronary artery anomalies in Kawasaki disease. Ann Noninvasive Electrocardiol. 2017 Mar;22(2). PubMed PMID: 27682160
  • Friesen RM, Schäfer M, Jone PN, Appiawiah N, Vargas D, Fonseca B, DiMaria MV, Truong U, Malone L, Browne LP. Myocardial Perfusion Reserve Index in Children With Kawasaki Disease. J Magn Reson Imaging. 2017 Dec 12. [Epub ahead of print] PubMed PMID: 29232024
  • Jone PN, Schäfer M, Li L, Craft M, Ivy DD, Kutty S. Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2017 Dec;10(12). PubMed PMID: 29233835
  • Chowdhury D, Gurvitz M, Marelli A, Anderson J, Baker-Smith C, Diab KA, Edwards TC, Hougen T, Jedeikin R, Johnson JN, Karpawich P, Lai W, Lu JC, Mitchell S, Newburger JW, Penny DJ, Portman MA, Satou G, Teitel D, Villafane J, Williams R, Jenkins K. Development of Quality Metrics in Ambulatory Pediatric Cardiology. J Am Coll Cardiol. 2017 Feb 7;69(5):541-555. PubMed PMID: 28153110
  • Jone PN, Schäfer M, Li L, Craft M, Ivy DD, Kutty S. Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2017 Dec;10(12). PubMed PMID: 29233835
  • Cortez D, Sharma N, Jone PN. Atrioventricular depolarization differences identify coronary artery anomalies in Kawasaki disease. Ann Noninvasive Electrocardiol. 2016 Sep 28. [Epub ahead of print] PubMed PMID: 27682160
  • Frank B, Davidson J, Tong S, Martin B, Heizer H, Anderson MS, Glode MP, Dominguez SR, Jone PN. Myocardial Strain and Strain Rate in Kawasaki Disease: Range, Recovery, and Relationship to Systemic Inflammation/Coronary Artery Dilation. J Clin Exp Cardiolog. 2016 Apr;7(4). PubMed PMID: 27182455
  • Jone PN, Ross MM, Bracken JA, Mulvahill MJ, Di Maria MV, Fagan TE. Feasibility and Safety of Using a Fused Echocardiography/Fluoroscopy Imaging System in Patients with Congenital Heart Disease. J Am Soc Echocardiogr. 2016 Jun;29(6):513-21. PubMed PMID: 27143284
  • Jone PN, Patel SS, Cassidy C, Ivy DD. Three-dimensional Echocardiography of Right Ventricular Function Correlates with Severity of Pediatric Pulmonary Hypertension. Congenit Heart Dis. 2016 Feb 22. [Epub ahead of print] PubMed PMID: 26899626
  • Bremen C, Campbell DN, Browne L, Jone PN. Multiple Coronary Artery Aneurysms of the Right Coronary Artery in Neonate with Pulmonary Atresia with Intact Ventricular Septum. Echocardiography. 2016 Jun;33(6):936-938. PubMed PMID: 26857432
  • Cortez D, Patel SS, Sharma N, Landeck BF, McCanta AC, Jone PN. Repolarization Vector Magnitude Differentiates Kawasaki Disease from Normal Children. Ann Noninvasive Electrocardiol. 2016 Sep;21(5):493-9. PubMed PMID: 26780477
  • Dominguez SR, Martin B, Heizer H, Jone PN, Tong S, Davidson J, Anderson MS, Glodé MP. Procalcitonin (PCT) and Kawasaki Disease: Does PCT Correlate With IVIG-Resistant Disease, Admission to the Intensive Care Unit, or Development of Coronary Artery Lesions?. J Pediatric Infect Dis Soc. 2016 Sep;5(3):297-302. PubMed PMID: 26407256
  • Dominguez SR, Martin B, Heizer H, Jone PN, Tong S, Davidson J, Anderson MS, Glodé MP. Procalcitonin (PCT) and Kawasaki Disease: Does PCT Correlate with IVIG-Resistant Disease, Admission to the Intensive Care Unit, or Development of Coronary Artery Lesions?. J Pediatric Infect Dis Soc. 2015 Apr 20. [Epub ahead of print] PubMed PMID: 26407256
  • Turnier JL, Anderson MS, Heizer HR, Jone PN, Glodé MP, Dominguez SR. Concurrent Respiratory Viruses and Kawasaki Disease. Pediatrics. 2015 Sep;136(3):e609-14. PubMed PMID: 26304824
  • Phadke D, Patel SS, Dominguez SR, Heizer H, Anderson MS, Glode MP, Jone PN. Tissue Doppler Imaging as a Predictor of Immunoglobulin Resistance in Kawasaki Disease. Pediatr Cardiol. 2015 May 21. [Epub ahead of print] PubMed PMID: 25991572
  • Jone PN, Tapia D, Davidson J, Fagan TE, Browne L, Ing RJ, Kay J. Successful Treatment of Myocardial Infarction in an Infant With Kawasaki Disease. Semin Cardiothorac Vasc Anesth. 2015 Sep;19(3):255-9. PubMed PMID: 25700695
  • Jone PN, Bremen C, DiMaria M, Campbell DN, Jaggers J, Younoszai A, Ivy DD. Three-dimensional echocardiography enhances diagnostic accuracy of supramitral ring. Echocardiography. 2015 Jun;32(6):1048-50. PubMed PMID: 25496227
  • Jone PN, Mitchell MB, Campbell DN, da Cruz EM. Prenatal diagnosis and successful outcome in neonate of aorto-left ventricle tunnel. Echocardiography. 2014 Jan;31(1):E20-3. PubMed PMID: 24383948
  • Jone PN, Hinzman J, Wagner BD, Ivy DD, Younoszai A. Right ventricular to left ventricular diameter ratio at end-systole in evaluating outcomes in children with pulmonary hypertension. J Am Soc Echocardiogr. 2014 Feb;27(2):172-8. PubMed PMID: 24325962
  • Jone PN, Hinzman J, Wagner BD, Ivy DD, Younoszai A. Right ventricular to left ventricular diameter ratio at end-systole in evaluating outcomes in children with pulmonary hypertension. J Am Soc Echocardiogr. 2014 Feb;27(2):172-8. PubMed PMID: 24325962
  • Jone PN, Mitchell MB, Campbell DN, da Cruz EM. Prenatal diagnosis and successful outcome in neonate of aorto-left ventricle tunnel. Echocardiography. 2014;31(1):E20-3. PubMed PMID: 24383948
  • Fagan TE, Truong UT, Jone PN, Bracken J, Quaife R, Hazeem AA, Salcedo EE, Fonseca BM. Multimodality 3-dimensional image integration for congenital cardiac catheterization. Methodist Debakey Cardiovasc J. 2014 Apr-Jun;10(2):68-76. PubMed PMID: 25114757
  • Jone PN, Ivy DD. Echocardiography in pediatric pulmonary hypertension. Front Pediatr. 2014;2:124. PubMed PMID: 25429362
  • Jone PN, Bremen C, DiMaria M, Campbell DN, Jaggers J, Younoszai A, Ivy DD. Three-Dimensional Echocardiography Enhances Diagnostic Accuracy of Supramitral Ring. Echocardiography. 2014 Dec 12. [Epub ahead of print] PubMed PMID: 25496227
  • Hauck A, da Cruz EM, Jaggers J, Jone PN. Tricuspid Atresia Associated with Truncus Arteriosus versus Aortopulmonary Window: Combining Fetal and Postnatal Echocardiography to Make the Diagnosis. Echocardiography. 2013 Sep 4. [Epub ahead of print] PubMed PMID: 24033694
  • Takatsuki S, Nakayama T, Jone PN, Wagner BD, Naoi K, Ivy DD, Saji T. Tissue Doppler imaging predicts adverse outcome in children with idiopathic pulmonary arterial hypertension. J Pediatr. 2012 Dec;161(6):1126-31. PubMed PMID: 22748515
  • Takatsuki S, Nakayama T, Jone PN, Wagner BD, Naoi K, Ivy DD, Saji T. Tissue Doppler imaging predicts adverse outcome in children with idiopathic pulmonary arterial hypertension. J Pediatr. 2012 Dec;161(6):1126-31. PubMed PMID: 22748515
  • Jone PN, Schowengerdt KO Jr. Prenatal diagnosis of congenital heart disease. Pediatr Clin North Am. 2009 Jun;56(3):709-15, Table of Contents. PubMed PMID: 19501700
View All (63 Total) View Less

Professional Memberships

  • American Board of Pediatrics, Fellow
  • American Society of Echocardiography, Fellow
  • American Heart Association (AHA), Fellow
  • American College of Cardiology, Fellow

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

UCHealth Longs Peak Hospital
1750 E. Ken Pratt Boulevard
Longmont, CO 80504
720-718-7000

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Cardiology, Board Certification (2008)
  • Pediatrics, Board Certification (2004, 2014)
Conditions & Treatments
  • Heart and Circulation
  • Heart and Circulation - Congenital Heart Disease
  • Kawasaki Disease
Clinical Interests
My clinical interests are in congenital heart disease, 3D echocardiography, and Kawasaki Disease.

Care Philosophy
Patients are the at heart of what we do.

Volunteer Activities
Kawasaki Kids Foundation

Public Speaking
Yes
3D Echocardiography, Fusion Imaging, Kawasaki Disease, Echocardiography in Pulmonary Hypertension, RV Function, Congenital Heart Disease

General Information

Medical Schools:
  • MD, Northwestern University The Feinberg School of Medicine (2001)
Undergraduate Schools:
  • BS, Northwestern University (IL) (1997)
Residency Programs:
  • University of Minnesota Medical School Program, Pediatrics (2004)
Fellowships:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Pediatric Cardiology (2007)
Languages: English, Taiwanese, Mandarin
Department: Pediatrics-Cardiology
;