Amy Brooks-Kayal, MD
Professor, Pediatrics-Neurology

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Medical School:
  • MD, Johns Hopkins University School of Medicine (1988)
Undergraduate School:
  • AB, Cornell University (NY) (1984)
Internship:
  • Children's Hospital of Philadelphia Program (1989)
Residencies:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Child Neurology (1995)
  • Children's Hospital of Philadelphia Program, Pediatrics (1991)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Clinical Neurophysiology (1992)
Languages: English
Department: Pediatrics-Neurology

Professional Titles

  • Professor, Pediatrics-Neurology
  • Chief of Pediatric Neurology
  • Ponzio Family Chair in Pediatric Neurology
  • Co-Director Translational Epilepsy Research Program
Research interests for Patients:
My research focuses on understanding how seizures effect the brain and on development of novel treatments for the prevention, treatment and cure of epilepsy

Teaching

  • Professor (2008)
    School of Medicine, Pediatrics
    Pediatric Neurology; Epilepsy; GABA(A) Receptors
  • Professor (2009)
    School of Medicine, Neurology

Publications

  • Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. Epilepsia. 2018 Jan;59(1):37-66. PubMed PMID: 29247482
  • Demarest ST, Brooks-Kayal A. From molecules to medicines: the dawn of targeted therapies for genetic epilepsies. Nat Rev Neurol. 2018 Dec;14(12):735-745. PubMed PMID: 30448857
  • Li Z, Cogswell M, Hixson K, Brooks-Kayal AR, Russek SJ. Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons. Front Mol Neurosci. 2018;11:285. PubMed PMID: 30186109
  • Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. Epilepsia. 2018 Jan;59(1):37-66. PubMed PMID: 29247482
  • Simonato M, Iyengar S, Brooks-Kayal A, Collins S, Depaulis A, Howells DW, Jensen F, Liao J, Macleod MR, Patel M, Potschka H, Walker M, Whittemore V, Sena ES. Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 Nov;58 Suppl 4:68-77. PubMed PMID: 29105071
  • Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. 2016 Dec 30. [Epub ahead of print] PubMed PMID: 28035782
  • Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. 2016 Dec 30. [Epub ahead of print] PubMed PMID: 28035782
  • Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Mar 30;3(1). PubMed PMID: 27057559
  • Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Exp Neurol. 2015 Sep;271:445-56. PubMed PMID: 26172316
  • González MI, Grabenstatter HL, Cea-Del Rio CA, Cruz Del Angel Y, Carlsen J, Laoprasert RP, White AM, Huntsman MM, Brooks-Kayal A. Seizure-related regulation of GABAA receptors in spontaneously epileptic rats. Neurobiol Dis. 2015 May;77:246-56. PubMed PMID: 25769812
  • Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb;62:73-85. PubMed PMID: 24051278
  • Grabenstatter HL, Cogswell M, Cruz Del Angel Y, Carlsen J, Gonzalez MI, Raol YH, Russek SJ, Brooks-Kayal AR. Effect of spontaneous seizures on GABAA receptor a4 subunit expression in an animal model of temporal lobe epilepsy. Epilepsia. 2014 Nov;55(11):1826-33. PubMed PMID: 25223733
  • Simonato M, Brooks-Kayal AR, Engel J Jr, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of anti-epileptic therapy development in animal models. Lancet Neurol. 2014 Sep;13(9):949-60. PubMed PMID: 25127174
  • Raible DJ, Frey LC, Brooks-Kayal AR. Effects of JAK2-STAT3 signaling after cerebral insults. JAKSTAT. 2014;3:e29510. PubMed PMID: 25105066
  • Scharfman HE, Brooks-Kayal AR. Is plasticity of GABAergic mechanisms relevant to epileptogenesis?. Adv Exp Med Biol. 2014;813:133-50. PubMed PMID: 25012373
  • Pearl PL, McConnell ER, Fernandez R, Brooks-Kayal A. Survey of the professors of child neurology: neurology versus pediatrics home for child neurology. Pediatr Neurol. 2014 Sep;51(3):344-7. PubMed PMID: 24993248
  • Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. J Neurosci Res. 2014 Oct;92(10):1307-18. PubMed PMID: 24801281
  • Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb;62:73-85. PubMed PMID: 24051278
  • Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Authors' response to letter by A. Mazarati. Epilepsia. 2013 Dec;54(12):2229-30. PubMed PMID: 24304440
  • Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, McArthur DL, Wu JY, Leung M, Buxey F, Szeliga C, Van Hirtum-Das M, Sankar R, Brooks-Kayal A, Giza CC. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia. 2013 Oct;54(10):1780-8. PubMed PMID: 24032982
  • Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 2013 Aug;54 Suppl 4:44-60. PubMed PMID: 23909853
  • Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. Issues related to development of antiepileptogenic therapies. Epilepsia. 2013 Aug;54 Suppl 4:35-43. PubMed PMID: 23909852
  • González MI, Cruz Del Angel Y, Brooks-Kayal A. Down-regulation of gephyrin and GABAA receptor subunits during epileptogenesis in the CA1 region of hippocampus. Epilepsia. 2013 Apr;54(4):616-24. PubMed PMID: 23294024
  • Grabenstatter HL, Russek SJ, Brooks-Kayal AR. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 2012 Dec;53 Suppl 9:71-8. PubMed PMID: 23216580
  • Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, Brooks-Kayal AR. GABA(A) receptor regulation after experimental traumatic brain injury. J Neurotrauma. 2012 Nov 1;29(16):2548-54. PubMed PMID: 22827467
  • Brooks-Kayal AR, Russek SJ, Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV. Regulation of GABA(A) Receptor Gene Expression and Epilepsy. . 2012. PubMed PMID: 22787609
  • Chapman KE, Raol YH, Brooks-Kayal A. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci. 2012 Jun;35(12):1857-65. PubMed PMID: 22708596
  • Raol YH, Brooks-Kayal AR. Experimental models of seizures and epilepsies. Prog Mol Biol Transl Sci. 2012;105:57-82. PubMed PMID: 22137429
  • Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. J Neurochem. 2012 Jan;120(2):210-9. PubMed PMID: 22035109
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Professional Memberships

  • American Epilepsy Society, Past President, Nominating Committee
  • American Neurological Association, Executive Committee, Membership Committee
  • Society for Neuroscience, Awards Committee
  • Child Neurology Society, Member
  • Professors of Child Neurology, Member
  • American Academy of Neurology, Member
  • National Institute of Neurological Diseases and Stroke, Member, Advisory Council

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Child Neurology, Board Certification (1996, 2016)
  • Clinical Neurophysiology, Board Certification (1997)
  • Pediatrics, Board Certification (1991)
  • Epilepsy, Board Certification (2014)
Conditions & Treatments
  • Brain and Nervous System
  • Brain and Nervous System - Epilepsy
Clinical Interest for Patients
I specialize in the care of children and teens with difficult to manage or complex epilepsy.

General Information

Medical Schools:
  • MD, Johns Hopkins University School of Medicine (1988)
Undergraduate Schools:
  • AB, Cornell University (NY) (1984)
Internships:
  • Children's Hospital of Philadelphia Program (1989)
Residency Programs:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Child Neurology (1995)
  • Children's Hospital of Philadelphia Program, Pediatrics (1991)
Fellowships:
  • University of Pennsylvania/Children's Hospital of Philadelphia Program, Clinical Neurophysiology (1992)
Languages: English
Department: Pediatrics-Neurology
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