Sarah Faubel, MD
Professor, Medicine-Renal Med Diseases/Hypertension

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Medical School:
  • MD, Wayne State University School of Medicine (1995)
Undergraduate School:
  • BA, Wellesley College (MA) (1990)
Internship:
  • Detroit Medical Center Program (1996)
Residency:
  • University of Colorado (University Hospital) Program, Internal Medicine (1999)
Fellowships:
  • University of Colorado (University Hospital) Program, Nephrology (2003)
Languages: English
Department: Medicine-Renal Med Diseases/Hypertension

Publications

  • Griffin BR, Wu C, O'Horo JC, Faubel S, Jalal D, Kashani K. The Association of Platelet Decrease Following Continuous Renal Replacement Therapy Initiation and Increased Rates of Secondary Infections. Crit Care Med. 2021 Feb 1;49(2):e130-e139. PubMed PMID: 33372743
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M. Creatinine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg. 2020 Jun 26. [Epub ahead of print] PubMed PMID: 32739165
  • Gist KM, Faubel S. Infection Post-AKI: Should We Worry?. Nephron. 2020;144(12):673-676. PubMed PMID: 32564024
  • Faubel S. The author replies. Kidney Int. 2020 Jun;97(6):1301-1302. PubMed PMID: 32444098
  • Faubel S. SuPAR: a potential predictive biomarker for acute kidney injury. Nat Rev Nephrol. 2020 Jul;16(7):375-376. PubMed PMID: 32269303
  • Barhight MF, Brinton JT, Soranno DE, Faubel S, Mourani PM, Gist KM. Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury. Pediatr Nephrol. 2020 Jul;35(7):1331-1339. PubMed PMID: 32152726
  • Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 May;97(5):966-979. PubMed PMID: 32081304
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia After Cardiopulmonary Bypass Is Associated With Increased Morbidity and Mortality. Ann Thorac Surg. 2020 Jul;110(1):50-57. PubMed PMID: 31816284
  • Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-Compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res. 2020 Mar;247:136-143. PubMed PMID: 31785887
  • Griffin BR, Gist KM, Faubel S. Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective. J Intensive Care Med. 2020 May;35(5):415-424. PubMed PMID: 30654681
  • Teixeira JP, Ambruso S, Griffin BR, Faubel S. Pulmonary Consequences of Acute Kidney Injury. Semin Nephrol. 2019 Jan;39(1):3-16. PubMed PMID: 30606405
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia After Cardiopulmonary Bypass is Associated with Increased Morbidity and Mortality. Ann Thorac Surg. 2019 Dec 6. [Epub ahead of print] PubMed PMID: 31816284
  • Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res. 2019 Nov 27. [Epub ahead of print] PubMed PMID: 31785887
  • Griffin BR, Thomson A, Yoder M, Francis I, Ambruso S, Bregman A, Feller M, Johnson-Bortolotto S, King C, Bonnes D, Dufficy L, Wu C, Bansal A, Tad-Y D, Faubel S, Jalal D. Continuous Renal Replacement Therapy Dosing in Critically Ill Patients: A Quality Improvement Initiative. Am J Kidney Dis. 2019 Dec;74(6):727-735. PubMed PMID: 31540789
  • Griffin BR, You Z, Holmen J, SooHoo M, Gist KM, Colbert JF, Chonchol M, Faubel S, Jovanovich A. Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis. PLoS One. 2019;14(6):e0217935. PubMed PMID: 31233518
  • Soranno DE, Gil HW, Kirkbride-Romeo L, Altmann C, Montford JR, Yang H, Levine A, Buchanan J, Faubel S. Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia. J Am Soc Nephrol. 2019 Jun;30(6):990-1005. PubMed PMID: 31072827
  • Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit. 2019 Apr;41(2):213-226. PubMed PMID: 30883514
  • Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 Mar;95(3):590-610. PubMed PMID: 30709662
  • Griffin BR, Gist KM, Faubel S. Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective. J Intensive Care Med. 2019 Jan 17;:885066618824531. [Epub ahead of print] PubMed PMID: 30654681
  • Teixeira JP, Ambruso S, Griffin BR, Faubel S. Pulmonary Consequences of Acute Kidney Injury. Semin Nephrol. 2019 Jan;39(1):3-16. PubMed PMID: 30606405
  • Griffin BR, Jovanovich A, You Z, Palevsky P, Faubel S, Jalal D. Effects of Baseline Thrombocytopenia and Platelet Decrease Following Renal Replacement Therapy Initiation in Patients With Severe Acute Kidney Injury. Crit Care Med. 2019 Apr;47(4):e325-e331. PubMed PMID: 30585829
  • Griffin BR, Jovanovich A, You Z, Palevsky P, Faubel S, Jalal D. Effects of Baseline Thrombocytopenia and Platelet Decrease Following Renal Replacement Therapy Initiation in Patients With Severe Acute Kidney Injury. Crit Care Med. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30585829
  • Griffin BR, Faubel S, Edelstein CL. Biomarkers of drug-induced kidney toxicity. Ther Drug Monit. 2018 Dec 10. [Epub ahead of print] PubMed PMID: 30531196
  • Barhight MF, Brinton J, Stidham T, Soranno DE, Faubel S, Griffin BR, Goebel J, Mourani PM, Gist KM. Increase in chloride from baseline is independently associated with mortality in critically ill children. Intensive Care Med. 2018 Dec;44(12):2183-2191. PubMed PMID: 30382307
  • Barhight MF, Soranno D, Faubel S, Gist KM. Fluid Management With Peritoneal Dialysis After Pediatric Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2018 Nov;9(6):696-704. PubMed PMID: 30322362
  • SooHoo MM, Patel SS, Jaggers J, Faubel S, Gist KM. Acute Kidney Injury Defined by Fluid Corrected Creatinine in Neonates After the Norwood Procedure. World J Pediatr Congenit Heart Surg. 2018 Sep;9(5):513-521. PubMed PMID: 30157730
  • Gist KM, Cooper DS, Wrona J, Faubel S, Altmann C, Gao Z, Marino BS, Alten J, Hock KM, Mizuno T, Vinks AA, Joy MS, Wempe MF, Bennett MR, Goldstein SL. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Ther Drug Monit. 2018 Apr;40(2):186-194. PubMed PMID: 29529007
  • SooHoo M, Griffin B, Jovanovich A, Soranno DE, Mack E, Patel SS, Faubel S, Gist KM. Acute kidney injury is associated with subsequent infection in neonates after the Norwood procedure: a retrospective chart review. Pediatr Nephrol. 2018 Jul;33(7):1235-1242. PubMed PMID: 29508077
  • Barhight MF, Lusk J, Brinton J, Stidham T, Soranno DE, Faubel S, Goebel J, Mourani PM, Gist KM. Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy. Pediatr Nephrol. 2018 Jun;33(6):1079-1085. PubMed PMID: 29404689
  • Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 Feb;47(2):128-131. PubMed PMID: 27617672
  • Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan;12(1):48-60. PubMed PMID: 26434402
  • Askenazi DJ, Heung M, Connor MJ Jr, Basu RK, Cerdá J, Doi K, Koyner JL, Bihorac A, Golestaneh L, Vijayan A, Okusa MD, Faubel S. Optimal Role of the Nephrologist in the Intensive Care Unit. Blood Purif. 2016 Dec 3;43(1-3):68-77. [Epub ahead of print] PubMed PMID: 27923227
  • Faubel S, Shah PB. Immediate Consequences of Acute Kidney Injury: The Impact of Traditional and Nontraditional Complications on Mortality in Acute Kidney Injury. Adv Chronic Kidney Dis. 2016 May;23(3):179-85. PubMed PMID: 27113694
  • Soranno DE, Rodell CB, Altmann C, Duplantis J, Andres-Hernando A, Burdick JA, Faubel S. Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F362-72. PubMed PMID: 26962109
  • Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP. Bridging translation for acute kidney injury with better preclinical modeling of human disease. Am J Physiol Renal Physiol. 2016 May 15;310(10):F972-84. PubMed PMID: 26962107
  • Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment. Am J Kidney Dis. 2016 Jul;68(1):19-28. PubMed PMID: 26948834
  • Gist KM, Kaufman J, da Cruz EM, Friesen RH, Crumback SL, Linders M, Edelstein C, Altmann C, Palmer C, Jalal D, Faubel S. A Decline in Intraoperative Renal Near-Infrared Spectroscopy Is Associated With Adverse Outcomes in Children Following Cardiac Surgery. Pediatr Crit Care Med. 2016 Apr;17(4):342-9. PubMed PMID: 26914625
  • Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan;12(1):48-60. PubMed PMID: 26434402
  • Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb;37(1):144-50. PubMed PMID: 25310769
  • de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE Jr, Pullen N, Okusa MD, Faubel S. Bridging Translation by Improving Preclinical Study Design in AKI. J Am Soc Nephrol. 2015 Dec;26(12):2905-16. PubMed PMID: 26538634
  • Dobrinskikh E, Lewis L, Brian Doctor R, Okamura K, Lee MG, Altmann C, Faubel S, Kopp JB, Blaine J. Shank2 Regulates Renal Albumin Endocytosis. Physiol Rep. 2015 Sep;3(9). PubMed PMID: 26333830
  • Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1868-74. PubMed PMID: 26220818
  • Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1859-67. PubMed PMID: 26138260
  • Rodell CB, Rai R, Faubel S, Burdick JA, Soranno DE. Local immunotherapy via delivery of interleukin-10 and transforming growth factor ß antagonist for treatment of chronic kidney disease. J Control Release. 2015 May 28;206:131-9. PubMed PMID: 25804871
  • Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb;37(1):144-50. PubMed PMID: 25310769
  • Faubel S. Renal relevant radiology: introduction. Clin J Am Soc Nephrol. 2014 Feb;9(2):371-2. PubMed PMID: 24510108
  • Faubel S, Patel NU, Lockhart ME, Cadnapaphornchai MA. Renal Relevant Radiology: Use of Ultrasonography in Patients with AKI. Clin J Am Soc Nephrol. 2014 Feb;9(2):382-94. PubMed PMID: 24235286
  • Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan;38(1):152-5. PubMed PMID: 23689355
  • Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ Jr. Preparing for renal replacement therapy in patients with the ebola virus disease. Blood Purif. 2014;38(3-4):276-85. PubMed PMID: 25675963
  • Hung KW, Blaine J, Faubel S. Dual therapy difficulties in angiotensin blockade for proteinuria: a teachable moment. JAMA Intern Med. 2014 Sep;174(9):1429-30. PubMed PMID: 25089763
  • Andres-Hernando A, Altmann C, Bhargava R, Okamura K, Bacalja J, Hunter B, Ahuja N, Soranno D, Faubel S. Prolonged acute kidney injury exacerbates lung inflammation at 7 days post-acute kidney injury. Physiol Rep. 2014 Jul 1;2(7). PubMed PMID: 25052489
  • Koyner JL, Cerdá J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S, Acute Kidney Injury Advisory Group of the American Society of Nephrology. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. Am J Kidney Dis. 2014 Sep;64(3):394-401. PubMed PMID: 24815216
  • Faubel S. Renal relevant radiology: introduction. Clin J Am Soc Nephrol. 2014 Feb;9(2):371-2. PubMed PMID: 24510108
  • Faubel S, Patel NU, Lockhart ME, Cadnapaphornchai MA. Renal relevant radiology: use of ultrasonography in patients with AKI. Clin J Am Soc Nephrol. 2014 Feb;9(2):382-94. PubMed PMID: 24235286
  • Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan;38(1):152-5. PubMed PMID: 23689355
  • Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ Jr. Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood Purif. 2014;38(3-4):276-85. PubMed PMID: 25675963
  • Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov;1(6):e00153. PubMed PMID: 24400155
  • Faubel S. Have we reached the limit of mortality benefit with our approach to renal replacement therapy in acute kidney injury?. Am J Kidney Dis. 2013 Dec;62(6):1030-3. PubMed PMID: 24267387
  • Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013;8(11):e79037. PubMed PMID: 24265742
  • Bhargava R, Janssen W, Altmann C, Andrés-Hernando A, Okamura K, Vandivier RW, Ahuja N, Faubel S. Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice. PLoS One. 2013;8(5):e61405. PubMed PMID: 23667439
  • Goldstein SL, Jaber BL, Faubel S, Chawla LS, Acute Kidney Injury Advisory Group of American Society of Nephrology. AKI transition of care: a potential opportunity to detect and prevent CKD. Clin J Am Soc Nephrol. 2013 Mar;8(3):476-83. PubMed PMID: 23471414
  • Okamura K, Dummer P, Kopp J, Qiu L, Levi M, Faubel S, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS One. 2013;8(1):e54817. PubMed PMID: 23382978
  • Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013 Jan 17;14:17. PubMed PMID: 23327592
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Professional Memberships

  • American Medical Association, Member
  • American Society of Nephrology, Member
  • International Society of Nephrology, Member
  • National Kidney Foundation, Member

Practice Locations

Rocky Mountain Regional Veterans Administration Medical Center
1700 Wheeling St
Aurora, CO 80045
303-399-8020

Hospital Affiliation
  • Veterans Affairs Medical Center
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2010)
  • Nephrology, Board Certification (2010)

General Information

Medical Schools:
  • MD, Wayne State University School of Medicine (1995)
Undergraduate Schools:
  • BA, Wellesley College (MA) (1990)
Internships:
  • Detroit Medical Center Program (1996)
Residency Programs:
  • University of Colorado (University Hospital) Program, Internal Medicine (1999)
Fellowships:
  • University of Colorado (University Hospital) Program, Nephrology (2003)
Languages: English
Department: Medicine-Renal Med Diseases/Hypertension
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