Rachelle Nuss, MD

Research Interests

Publications

• Hematology chapter in Lange
• Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkely sickle cell anemia mice.
• Return visit rates after an emergency department discharge for children with sickle cell pain episodes
• Association between acute pain scores in children with sickle cell disease and emergency department disposition and return visit rates
• Extracellular vesicle size reveals cargo specific to coagulation and inflammation in pediatric and adult sickle cell disease
• Metabolic and proteomic divergence is present in circulating monocytes and tissue resident macrophages from Berkely sickle cell anemia and Beta thalassemia mice,
• Minimizing acute toxicity7 and late effects in the treatment of hodgkin lymphoma in patients with sickle cell disease
• Nuss R. Medical Conditions and High-Altitude Travel. N Engl J Med. 2022 May 12;386(19):1866. PubMed PMID: 35544404
• Karoor V, Swindle D, Pak DI, Strassheim D, Fini MA, Dempsey E, Stenmark KR, Hassell K, Nuss R, Buehler PW, Irwin DC. Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia. Pulm Circ. 2021 Oct-Dec;11(4):20458940211056806. PubMed PMID: 34777787
• Buehler PW, Swindle D, Pak DI, Fini MA, Hassell K, Nuss R, Wilkerson RB, D'Alessandro A, Irwin DC. Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features. Pulm Circ. 2021 Oct-Dec;11(4):20458940211055996. PubMed PMID: 34777785
• Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107. PubMed PMID: 34478834
• Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107. PubMed PMID: 34478834
• Underdown MJ, Nuss R. Thrombocytopenia in a teen with sickle cell disease following COVID-19 vaccination. Pediatr Blood Cancer. 2021 Dec;68(12):e29271. PubMed PMID: 34331506
• Casella JF, Barton BA, Kanter J, Black LV, Majumdar S, Inati A, Wali Y, Drachtman RA, Abboud MR, Kilinc Y, Fuh BR, Al-Khabori MK, Takemoto CM, Salman E, Sarnaik SA, Shah N, Morris CR, Keates-Baleeiro J, Raj A, Alvarez OA, Hsu LL, Thompson AA, Sisler IY, Pace BS, Noronha SA, Lasky JL 3rd, de Julian EC, Godder K, Thornburg CD, Kamberos NL, Nuss R, Marsh AM, Owen WC, Schaefer A, Tebbi CK, Chantrain CF, Cohen DE, Karakas Z, Piccone CM, George A, Fixler JM, Singleton TC, Moulton T, Quinn CT, de Castro Lobo CL, Almomen AM, Goyal-Khemka M, Maes P, Emanuele M, Gorney RT, Padgett CS, Parsley E, Kronsberg SS, Kato GJ, Gladwin MT. Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA. 2021 Apr 20;325(15):1513-1523. PubMed PMID: 33877274
• Loi M, Branchford B, Kim J, Self C, Nuss R. COVID-19 anticoagulation recommendations in children. Pediatr Blood Cancer. 2020 Sep;67(9):e28485. PubMed PMID: 32558124
• A quality initiative to decrease time to antibiotics in children with sickle cell disease and fever. McKinney C, Caruso-Brown A, Montgomery K, et al. Nuss R. Pediatric Quality and Safety: January/February 2020-volume5-issue 1-pe245 doi: 10.1097/pq9.0000000245
• Loi M, Branchford B, Kim J, Self C, Nuss R. COVID-19 anticoagulation recommendations in children. Pediatr Blood Cancer. 2020 Jun 18;:e28485. [Epub ahead of print] PubMed PMID: 32558124
• Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 Aug 8;4(15). PubMed PMID: 31391342
• Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2019 Feb;597(4):1073-1085. PubMed PMID: 29931797
• Redinus K, et al. Evidence of a novel Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. Citation Information: JCI Insight. 2019;4(15):e127860. https://doi.org/10.1172/jci.insight.127860.
• Palau MA, Winters A, LIangX, Nuss R, Niermeyer S, Gossling M, Wright C:Vitamin K deficiency presenting in an infant with an anterior mediastinal mass: A case report and review of the literature. Case Reports in Pediatrics 2017;
• Micro Particles from children with sickle cell anemia and the acute chest syndrome cause activation of human pulmonary endothelium
• impact of embedding a care manager from a publicly funded health care organization into a sickle cell team
• Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia
• Hematology chapter in: Current diagnosis and treatment pediatrics, 22nd edition. 2016
• Red cell exchange transfusion halts progressive proliferative sickle cell retinopathy in a teenaged patient with hemoglobin SC disease. Pediatr Blood Cancer 2015; 62:721-3
• Irwin DC, Beck JH, Hassell K, Nuss R, et al: hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonaryhypertension and is attenuated in rats with repeat dose hapto9globin administration. Free Radic Biol Med, 2015, 82: 50-62.
• Irwin DC, Grayck E, Hassell K, Nuss R, et al: Hypoxic pulmonary hypertension and the role of extra-cellular hemoglobin in perivascular mocrophage accumulation. Macrophage 2015; 2: 884-901.
• Goodman J, Hassell K, Irwin D, Witkowski EH, Nuss R. The splenic syndrome in individuals with sickle cell trait. High Alt Med Biol. 2014 Dec;15(4):468-71. PubMed PMID: 25361178
• Hematology chapter in Current Pediatrics, Lange 2014
• Overholser LS, Hassell K, Nuss R, et al. Implementing a patient navigation program to enhance care coordination for individuals with sickle cell disease: Lessons learned in an academic medical center. JCOM 2014; 21: 307.
• Lisk C, Kominsky D, Ehrentraut S, Bonaventura J, Nuss R, Hassell K, Nozik-Grayck E, Irwin DC. Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. Am J Respir Cell Mol Biol. 2013 Oct;49(4):619-26. PubMed PMID: 23713977
• Ball JB, Khan SY, McLaughlin NJD, Kelker MR, Nuss R, Cole L, Silliman CC: A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2. Pediatri Blood Cancer 2012; 58:399-405.
• Takatsuki S, Ivy DD, Nuss R: Correlation of n-terminal fragment B-type natriuretic peptide levels with clinical, laboratory, and echocardiographic abnormalities in children. J Pediatr 2012; 160:428-433.
• Overholser LS, Hassell K, Nuss R, et al. Implementing a patient navigation program to enhance care coordination for individuals with sickle cell disease: Lessons learned in an academic medical center. JCOM 2014 in press
• McKinney C, et al. Nuss R: Red cell exchange transfusion halts progressive proliferative sickle cell retinopathy in a teenaged patient with hemoglobin SC disease. Accepted Pediatr Blood Cancer 2014
• Goodman J, Hassell K, Irwin D, Witkowski EH, Nuss R: The splenic syndrome in individuals with sickle cell trait. High Altitude medicine and biology. Accepted 2014:

Practice Locations

• Children's Hospital Colorado

• Colorado Sickle Cell Treatment and Research Center

Specialty Information

• Pediatrics, Board Certification
• Pediatric Hematology / Oncology, Board Certification

• Cancers
• Blood / Lymphatic System - Blood Disorders
• Blood / Lymphatic System - Bleeding Disorders
• Blood / Lymphatic System