Andres Vazquez-Torres, PhD
Professor, Immunology and Microbiology

Publications

• Kim JS, Liu L, Kant S, Orlicky DJ, Uppalapati S, Margolis A, Davenport BJ, Morrison TE, Matsuda J, McClelland M, Jones-Carson J, Vazquez-Torres A. Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase. Cell Host Microbe. 2024 Jan 24. [Epub ahead of print] PubMed PMID: 38307020
• Kant S, Liu L, Vazquez-Torres A. The methylglyoxal pathway is a sink for glutathione in Salmonella experiencing oxidative stress. PLoS Pathog. 2023 Jun;19(6):e1011441. PubMed PMID: 37267419
• Margolis A, Liu L, Porwollik S, Till JKA, Chu W, McClelland M, Vázquez-Torres A. Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress. Infect Immun. 2023 Jun 15;91(6):e0012023. PubMed PMID: 37191509
• Kant S, Till JKA, Liu L, Margolis A, Uppalapati S, Kim JS, Vazquez-Torres A. Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes. PLoS Biol. 2023 Apr;21(4):e3002051. PubMed PMID: 37014914
• Kim JS, Born A, Till JKA, Liu L, Kant S, Henen MA, Vögeli B, Vázquez-Torres A. Promiscuity of response regulators for thioredoxin steers bacterial virulence. Nat Commun. 2022 Oct 20;13(1):6210. PubMed PMID: 36266276
• Uppalapati SR, Vazquez-Torres A. Manganese Utilization in Salmonella Pathogenesis: Beyond the Canonical Antioxidant Response. Front Cell Dev Biol. 2022;10:924925. PubMed PMID: 35903545
• Kim JS, Liu L, Davenport B, Kant S, Morrison TE, Vazquez-Torres A. Oxidative stress activates transcription of Salmonella pathogenicity island-2 genes in macrophages. J Biol Chem. 2022 Jul;298(7):102130. PubMed PMID: 35714768
• Kitzenberg DA, Lee JS, Mills KB, Kim JS, Liu L, Vázquez-Torres A, Colgan SP, Kao DJ. Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics. mBio. 2022 Jun 28;13(3):e0048022. PubMed PMID: 35575513
• Chakraborty S, Liu L, Fitzsimmons L, Porwollik S, Kim JS, Desai P, McClelland M, Vazquez-Torres A. Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ?pH. Nat Commun. 2020 Apr 14;11(1):1783. PubMed PMID: 32286292
• Jones-Carson J, Yahashiri A, Kim JS, Liu L, Fitzsimmons LF, Weiss DS, Vázquez-Torres A. Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism. Sci Adv. 2020 Feb;6(9):eaaz0260. PubMed PMID: 32133408
• Fitzsimmons LF, Liu L, Kant S, Kim JS, Till JK, Jones-Carson J, Porwollik S, McClelland M, Vazquez-Torres A. SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. mBio. 2020 Feb 25;11(1). PubMed PMID: 32098823
• Pérez-Varela M, Tierney ARP, Kim JS, Vázquez-Torres A, Rather P. Characterization of RelA in Acinetobacter baumannii. J Bacteriol. 2020 May 27;202(12). PubMed PMID: 32229531
• Fang FC, Vázquez-Torres A. Reactive nitrogen species in host-bacterial interactions. Curr Opin Immunol. 2019 Oct;60:96-102. PubMed PMID: 31200187
• Fang FC, Vázquez-Torres A. Reactive nitrogen species in host-bacterial interactions. Curr Opin Immunol. 2019 Oct;60:96-102. PubMed PMID: 31200187
• Kim JS, Liu L, Fitzsimmons LF, Wang Y, Crawford MA, Mastrogiovanni M, Trujillo M, Till JKA, Radi R, Dai S, Vázquez-Torres A. DksA-DnaJ redox interactions provide a signal for the activation of bacterial RNA polymerase. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11780-E11789. PubMed PMID: 30429329
• Davenport BJ, Martin CG, Beverley SM, Orlicky DJ, Vazquez-Torres A, Morrison TE. SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice. PLoS Negl Trop Dis. 2018 Oct;12(10):e0006921. PubMed PMID: 30372439
• Fitzsimmons L, Liu L, Porwollik S, Chakraborty S, Desai P, Tapscott T, Henard C, McClelland M, Vazquez-Torres A. Zinc-dependent substrate-level phosphorylation powers Salmonella growth under nitrosative stress of the innate host response. PLoS Pathog. 2018 Oct;14(10):e1007388. PubMed PMID: 30365536
• Tapscott T, Kim JS, Crawford MA, Fitzsimmons L, Liu L, Jones-Carson J, Vázquez-Torres A. Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region. Sci Rep. 2018 Jun 21;8(1):9465. PubMed PMID: 29930310
• Shaw JA, Henard CA, Liu L, Dieckman LM, Vázquez-Torres A, Bourret TJ. Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway. J Biol Chem. 2018 Jul 20;293(29):11271-11282. PubMed PMID: 29848552
• Fitzsimmons LF, Liu L, Kim JS, Jones-Carson J, Vázquez-Torres A. Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress. MBio. 2018 Feb 27;9(1). PubMed PMID: 29487237
• Vázquez-Torres A. Less Is Best in the Convergent Evolution of Typhoidal Salmonella. Cell Host Microbe. 2018 Feb 14;23(2):151-153. PubMed PMID: 29447692
• Bourret TJ, Liu L, Shaw JA, Husain M, Vázquez-Torres A. Magnesium homeostasis protects Salmonella against nitrooxidative stress. Sci Rep. 2017 Nov 8;7(1):15083. PubMed PMID: 29118452
• Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 Oct;85(10). PubMed PMID: 28717030
• Jones-Carson J, Husain M, Liu L, Orlicky DJ, Vázquez-Torres A. Cytochrome bd-Dependent Bioenergetics and Antinitrosative Defenses in Salmonella Pathogenesis. MBio. 2016 Dec 20;7(6). PubMed PMID: 27999164
• Fang FC, Frawley ER, Tapscott T, Vázquez-Torres A. Discrimination and Integration of Stress Signals by Pathogenic Bacteria. Cell Host Microbe. 2016 Aug 10;20(2):144-53. PubMed PMID: 27512902
• Fang FC, Frawley ER, Tapscott T, Vázquez-Torres A. Bacterial Stress Responses during Host Infection. Cell Host Microbe. 2016 Aug 10;20(2):133-43. PubMed PMID: 27512901
• Jarrett MJ, Vázquez-Torres A, Frank DN, McCollister BD, Henthorn PK, Ir D, Sheeder J, Guy MS, Anwar HQ, Behbakht K. Influence of Gelatin-Thrombin Matrix Tissue Sealant on Bacterial Colony Formation and Risk of Pelvic Infection. Infect Dis Obstet Gynecol. 2016;2016:2649708. PubMed PMID: 27199534
• Crawford MA, Tapscott T, Fitzsimmons LF, Liu L, Reyes AM, Libby SJ, Trujillo M, Fang FC, Radi R, Vázquez-Torres A. Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content. MBio. 2016 Apr 19;7(2):e02161-15. PubMed PMID: 27094335
• Crawford MA, Henard CA, Tapscott T, Porwollik S, McClelland M, Vázquez-Torres A. DksA-Dependent Transcriptional Regulation in Salmonella Experiencing Nitrosative Stress. Front Microbiol. 2016 Mar 31;7:444. PubMed PMID: 27065993
• Song M, Kim JS, Liu L, Husain M, Vázquez-Torres A. Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity. Cell Rep. 2016 Mar 29;14(12):2901-11. PubMed PMID: 26997275
• Vázquez-Torres A, Bäumler AJ. Nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens. Curr Opin Microbiol. 2016 Feb;29:1-8. PubMed PMID: 26426528
• Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI. A Burkholderia pseudomallei colony variant necessary for gastric colonization. MBio. 2015 Feb 3;6(1). PubMed PMID: 25650400
• Jones-Carson J, Zweifel AE, Tapscott T, Austin C, Brown JM, Jones KL, Voskuil MI, Vázquez-Torres A. Nitric oxide from IFN?-primed macrophages modulates the antimicrobial activity of ß-lactams against the intracellular pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella. PLoS Negl Trop Dis. 2014 Aug;8(8):e3079. PubMed PMID: 25121731
• Henard CA, Tapscott T, Crawford MA, Husain M, Doulias PT, Porwollik S, Liu L, McClelland M, Ischiropoulos H, Vázquez-Torres A. The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stress. Mol Microbiol. 2014 Feb;91(4):790-804. PubMed PMID: 24354846
• Husain M, Jones-Carson J, Liu L, Song M, Saah JR, Troxell B, Mendoza M, Hassan H, Vázquez-Torres A. Ferric uptake regulator-dependent antinitrosative defenses in Salmonella enterica serovar Typhimurium pathogenesis. Infect Immun. 2014 Jan;82(1):333-40. PubMed PMID: 24166960