Jill Slansky, PhD

Publications

• Hay Z.L.Z., D.D. Kim, J.M. Cimons, J.R. Knapp, M. E. Kohler, M. Quansah, T.M. Zúñiga, F.A. Camp, M. Fujita, X.J. Wang, B.P. O’Connor, and J.E. Slansky. Granzyme F: Exhaustion marker and modulator of CAR T cell-mediated cytotoxicity. J Immunol (2024).
• Elias AD, Staley AW, Fornier M, Vidal GA, Alami V, Sams S, Spoelstra NS, Goodspeed A, Kabos P, Diamond JR, Shagisultanova E, Gallagher RI, Wulfkuhle JD, Petricoin EF, Zolman KL, McSpadden T, Jordan KR, Slansky JE, Borges VF, Gao D, Richer JK. Clinical and immune responses to neoadjuvant fulvestrant with or without enzalutamide in ER /Her2- breast cancer. NPJ Breast Cancer. 2024 Oct 6;10(1):88. PubMed PMID: 39368973
• Hay ZLZ, Kim DD, Cimons JM, Knapp JR, Kohler ME, Quansah M, Zúñiga TM, Camp FA, Fujita M, Wang XJ, O'Connor BP, Slansky JE. Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell-Mediated Cytotoxicity. J Immunol. 2024 Apr 15;212(8):1381-1391. PubMed PMID: 38416029
• Hay ZLZ, Knapp JR, Magallon RE, O'Connor BP, Slansky JE. Low TCR Binding Strength Results in Increased Progenitor-like CD8 Tumor-Infiltrating Lymphocytes. Cancer Immunol Res. 2023 May 3;11(5):570-582. PubMed PMID: 36787375
• Camp FA, Brunetti TM, Williams MM, Christenson JL, Sreekanth V, Costello JC, Hay ZLZ, Kedl RM, Richer JK, Slansky JE. Antigens Expressed by Breast Cancer Cells Undergoing EMT Stimulate Cytotoxic CD8( ) T Cell Immunity. Cancers (Basel). 2022 Sep 9;14(18). PubMed PMID: 36139558
• Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu HH, Zhang Y, Li W, Wong WK, Deane CM, Neau D, Slansky JE, Thomas PG, Robey EA, Dai S. Peptide Centric Vß Specific Germline Contacts Shape a Specialist T Cell Response. Front Immunol. 2022;13:847092. PubMed PMID: 35967379
• Hay ZLZ, Slansky JE. Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity. Int J Mol Sci. 2022 Feb 6;23(3). PubMed PMID: 35163755
• Marín-Jiménez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021;12:607282. PubMed PMID: 33854497
• Williams MM, Christenson JL, O'Neill KI, Hafeez SA, Ihle CL, Spoelstra NS, Slansky JE, Richer JK. MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. NPJ Breast Cancer. 2021 May 27;7(1):64. PubMed PMID: 34045467
• Wei P, Jordan KR, Buhrman JD, Lei J, Deng H, Marrack P, Dai S, Kappler JW, Slansky JE, Yin L. Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). PubMed PMID: 34074778
• Camp FA, Slansky JE. Implications of Antigen Selection on T Cell-Based Immunotherapy. Pharmaceuticals (Basel). 2021 Sep 29;14(10). PubMed PMID: 34681217
• Camp FA, Slansky JE. Implications of Antigen Selection on T Cell-Based Immunotherapy. Pharmaceuticals (Basel). 2021 Sep 29;14(10). PubMed PMID: 34681217
• Wei P, Jordan KR, Buhrman JD, Lei J, Deng H, Marrack P, Dai S, *Kappler JW, *Slansky JE, *Yin L. Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). PubMed PMID: 34074778 *shared senior authors
• Williams MM, Christenson JL, O'Neill KI, Hafeez SA, Ihle CL, Spoelstra NS, Slansky JE, Richer JK. MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. NPJ Breast Cancer. 2021 May 27;7(1):64. PubMed PMID: 34045467
• Marín-Jiménez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021;12:607282. PubMed PMID: 33854497
• Jordan KR, Sikora MJ, Slansky JE, Minic A, Richer JK, Moroney MR, Hu J, Wolsky RJ, Watson ZL, Yamamoto TM, Costello JC, Clauset A, Behbakht K, Kumar TR, Bitler BG. The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval. Clin Cancer Res. 2020 Dec 1;26(23):6362-6373. PubMed PMID: 32928797
• Katz SC, Moody AE, Guha P, Hardaway JC, Prince E, LaPorte J, Stancu M, Slansky JE, Jordan KR, Schulick RD, Knight R, Saied A, Armenio V, Junghans RP. HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery. J Immunother Cancer. 2020 Aug;8(2). PubMed PMID: 32843493
• Hoffmann MM, Slansky JE. T-cell receptor affinity in the age of cancer immunotherapy. Mol Carcinog. 2020 Jul;59(7):862-870. PubMed PMID: 32386086
• Fajrial AK, He QQ, Wirusanti NI, Slansky JE, Ding X. A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing. Theranostics. 2020;10(12):5532-5549. PubMed PMID: 32373229
• Slansky JE, Nakayama M. Peptide mimotopes alter T cell function in cancer and autoimmunity. Semin Immunol. 2020 Feb;47:101395. PubMed PMID: 32205022
• Greene LI, Bruno TC, Christenson JL, D'Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK. A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma. Mol Cancer Res. 2019 Jan;17(1):131-139. PubMed PMID: 30143553
• Slansky JE, Spellman PT. Alternative Splicing in Tumors - A Path to Immunogenicity?. N Engl J Med. 2019 Feb 28;380(9):877-880. PubMed PMID: 30811916
• Westrich JA, Vermeer DW, Silva A, Bonney S, Berger JN, Cicchini L, Greer RO, Song JI, Raben D, Slansky JE, Lee JH, Spanos WC, Pyeon D. CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8( ) T-cell responses by upregulating MHC-I expression. Oncogene. 2019 Nov;38(46):7166-7180. PubMed PMID: 31417179
• Rabe JL, Gardner L, Hunter R, Fonseca JA, Dougan J, Gearheart CM, Leibowitz MS, Lee-Miller C, Baturin D, Fosmire SP, Zelasko SE, Jones CL, Slansky JE, Rupji M, Dwivedi B, Henry CJ, Porter CC. IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression. Cancer Res. 2019 Jul 15;79(14):3702-3713. PubMed PMID: 31142509
• Capasso A, Lang J, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, Eckhardt SG. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunother Cancer. 2019 Feb 8;7(1):37. PubMed PMID: 30736857
• Greene LI, Bruno TC, Christenson JL, D'Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK. A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma. Mol Cancer Res. 2019 Jan;17(1):131-139. PubMed PMID: 30143553
• Rozanov DV, Rozanov ND, Chiotti KE, Reddy A, Wilmarth PA, David LL, Cha SW, Woo S, Pevzner P, Bafna V, Burrows GG, Rantala JK, Levin T, Anur P, Johnson-Camacho K, Tabatabaei S, Munson DJ, Bruno TC, Slansky JE, Kappler JW, Hirano N, Boegel S, Fox BA, Egelston C, Simons DL, Jimenez G, Lee PP, Gray JW, Spellman PT. MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection. J Proteomics. 2018 Mar 30;176:13-23. PubMed PMID: 29331515
• Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL. Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest. 2018 Jun 1;128(6):2535-2550. PubMed PMID: 29757193
• Bruno TC, Ebner PJ, Moore BL, Squalls OG, Waugh KA, Eruslanov EB, Singhal S, Mitchell JD, Franklin WA, Merrick DT, McCarter MD, Palmer BE, Kern JA, Slansky JE. Antigen-Presenting Intratumoral B Cells Affect CD4( ) TIL Phenotypes in Non-Small Cell Lung Cancer Patients. Cancer Immunol Res. 2017 Oct;5(10):898-907. PubMed PMID: 28848053
• Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Landry LG, Eklund A, Nakayama M, Slansky JE, Grunewald J, Fontenot AP. Shared aß TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome. J Immunol. 2017 Oct 1;199(7):2279-2290. PubMed PMID: 28827283
• Slansky JE, Harmacek LD, O’Connor BP. Epigenetic profiling of tumor infiltrating lymphocytes.Trans Cancer Res. 2017;6(Supp6):S1104-S1107.
• Waugh KA, Leach SM, Moore BL, Bruno TC, Buhrman JD, Slansky JE. Molecular Profile of Tumor-Specific CD8 T Cell Hypofunction in a Transplantable Murine Cancer Model. J Immunol. 2016 Aug 15;197(4):1477-88. PubMed PMID: 27371726
• Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE. Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8272-7. PubMed PMID: 27307436
• Waugh KA, Leach SM, Slansky JE. Tolerance of Tumor-Specific T cells in Melanoma Metastases. J Clin Cell Immunol. 2016 Apr;7(2). PubMed PMID: 27213115
• Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV. Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes. Am J Respir Crit Care Med. 2016 Mar 15;193(6):614-26. PubMed PMID: 26551758
• Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV. Flow Cytometric Analysis of Mononuclear Phagocytes in Non-diseased Human Lung and Lung-draining Lymph Nodes. Am J Respir Crit Care Med. 2015 Nov 9. [Epub ahead of print] PubMed PMID: 26551758
• Waugh KA, Leach SM, Slansky JE. Targeting Transcriptional Regulators of CD8 T Cell Dysfunction to Boost Anti-Tumor Immunity. Vaccines (Basel). 2015 Sep 17;3(3):771-802. PubMed PMID: 26393659
• Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19;5:4674. PubMed PMID: 25135627
• Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19;5:4674. PubMed PMID: 25135627
• Buhrman JD, Jordan KR, Munson DJ, Moore BL, Kappler JW, Slansky JE. Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor. J Biol Chem. 2013 Nov 15;288(46):33213-25. PMC3829168
• Buhrman JD, Slansky JE. Mimotope vaccine efficacy gets a "boost" from native tumor antigens. Oncoimmunology. 2013 Apr 1;2(4):e23492. PMC3654579
• Buhrman JD, Jordan KR, U'ren L, Sprague J, Kemmler CB, Slansky JE. Augmenting antitumor T-cell responses to mimotope vaccination by boosting with native tumor antigens. Cancer Res. 2013 Jan 1;73(1):74-85. PMC3537842
• Slansky JE, Cohen JJ, Cambier JC. Integrated immunology in Colorado. Immunol Res. 2013 Mar;55(1-3):1-2. PMID: 22975788
• Bruno TC, French JD, Jordan KR, Ramirez O, Sippel TR, Borges VF, Haugen BR, McCarter MD, Waziri A, Slansky JE. Influence of human immune cells on cancer: studies at the University of Colorado. Immunol Res. 2013 Mar;55(1-3):22-33. PMID: 22941561
• Buhrman JD, Slansky JE. Improving T cell responses to modified peptides in tumor vaccines. Immunol Res. 2013 Mar;55(1-3):34-47. PMID: 22936035
• Buhrman JD, KR Jordan, L U'ren, J Sprague, CB Kemmler, JE Slansky. Augmenting antitumor T-cell responses to mimotope vaccination by boosting with native tumor antigens. Cancer Res, 73:74-85 (2013).
• Slansky JE, JJ Cohen, JC Cambier. Integrated immunology in Colorado. Immunol Res. 55:1-2(2013).
• Buhrman JD, JE Slansky. Improving T cell responses to modified peptides in tumor vaccines. Immunol Res.55:34-47 (2013).
• Buhrman JD, JE Slansky. Mimotope vaccine efficacy gets a "boost" from native tumor antigens. Oncoimmunology, 2:e23492 (2013).
• Bruno, TC, JD French, KR Jordan, O Ramirez, TR Sippel, VF Borges, BR Haugen, MD McCarter, A Waziri, JE Slansky. Influence of human immune cells on cancer: studies at the University of Colorado. Immunol Res, 55:22-33 (2013).
• Olino K., S. Wada, B.H. Edil, X. Pan, K. Meckel, W. Weber, J. Slansky, K. Tamada, P. Lauer, D. Brockstedt, D. Pardoll, R. Schulick, K. Yoshimura. Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases. Ann Surg Oncol 19:S597-607 (2012).
• Mitchell, L., S.W. Dow, J.E. Slansky, B.J. Biller. Induction of Remission Results in Spontaneous Enhancement of Anti-Tumor Cytotoxic T Lymphocyte Activity in Dogs with B cell Lymphoma. Veterinary Immunology and Immunopathology. Vet. Immunol. Immunopathol. 145:597-603 (2012).
• Jordan K.R., J.D. Buhrman, J. Sprague, B.L. Moore, D. Gao, J.W. Kappler, J.E Slansky. TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines. Cancer Immunol Immunother. 10.1007/s00262-012-1217-5 (2012). PMCID: In progress.
• Franks, A.L. and J.E. Slansky, Multiple Associations between a Broad Spectrum of Autoimmune Diseases, Chronic Inflammatory Diseases, and Cancer. Anticancer Res. 32(4):3-20(2012).
• Kemmler, C.B., E.T. Clambey, R.M. Kedl, J.E. Slansky. Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses, J. Immunol. 187: doi:10.4049/jimmunol.1101555. (2011). PMC2295286.
• Tamburini, B.A. T.L. Phang, S.P. Fosmire, M.C. Scott, S.C. Trapp, M.M. Duckett, S.R. Robinson, J.E. Slansky, L.C. Sharkey, G.R. Cutter, J.W. Wojcieszyn, D. Bellgrau, R.M. Gemmill, L.E. Hunter, J.F. Modiano. Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10:619 (2010).
• Slansky J.E. and K.R. Jordan, The Goldilocks Model for TCR affinity - too much attraction might not be best for vaccine design. PLoS Biology. 8(9): e1000482. doi:10.1371/journal.pbio.1000482 (2010).