Cara Mack, MD
Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

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Medical School:
  • MD, Loyola University Chicago Stritch School of Medicine (1992)
Undergraduate School:
  • BS, University of Wisconsin–Madison (WI) (1986)
Internship:
  • University of Chicago/Comer Children's Hospital Program (1993)
Residency:
  • University of Chicago/Comer Children's Hospital Program, Chief Resident, Pediatrics (1996)
Fellowships:
  • McGaw Medical Center of Northwestern University/Children's Memorial Hospital Program, Pediatric Gastroenterology (2001)
Languages: English
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition

Recognition & Awards

  • Inductee, Best Doctors in America, Best Doctors in America Inc., (2010)
  • Basil O'Connor Starter Scholar Research Award, March of Dimes Foundation, (2005)
  • Pediatric Research Abstract Award, American Association for the Study of Liver Disease, (2005)
  • Illinois Department of Public Health Scholarship, State of Illinois, (1990)
    clinical scholarship
  • Diabetes Young Investigator Award, Loyola University Stritch School of Medicine, (1989)
    research award
  • Phi Eta Sigma, Freshman Honor Society, Univ of WI Madison, (1983)
Research interests for Patients:
I am involved in many research projects with the overall theme of optimizing the lives of children with liver diseases. -I am investigating what causes the bile duct injury in biliary atresia. Furthermore, I am involved in a nationwide study to test different agents that may improve liver health in those with biliary atresia. -I am involved in a clinical research study investigating the use of a medicine to improve outcomes in sclerosing cholangitis.

Teaching

  • Associate Professor (2002)
    School of Medicine, Pediatrics
    Pediatric gastrointestinal diseases, liver diseases, liver transplant

Publications

  • Kilgore A, Mack CL. Update on investigations pertaining to the pathogenesis of biliary atresia. Pediatr Surg Int. 2017 Dec;33(12):1233-1241. PubMed PMID: 29063959
  • Mark JA, Mack CL, Marwan AI, Kramer RE. Use of Fully Covered Self-Expanding Metal Biliary Stents in Pediatrics: A Case Series. J Pediatr Gastroenterol Nutr. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28837510
  • Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL. Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. J Pediatr Gastroenterol Nutr. 2017 Jul;65(1):80-85. PubMed PMID: 28272159
  • Sundaram SS, Mack CL, Feldman AG, Sokol RJ. Biliary Atresia: Indications and Timing of Liver Transplantation and Optimization of Pre-Transplant Care. Liver Transpl. 2016 Sep 21. [Epub ahead of print] PubMed PMID: 27650268
  • Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):154-168. PubMed PMID: 27429428
  • Deneau MR, El-Matary W, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya KN, Gottrand M, Gottrand F, Gupta N, Homan M, Kamath BM, Kim KM, Kolho KL, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M, Miloh T, Mohan P, O'Cathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Jensen MK. The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. Hepatology. 2017 Aug;66(2):518-527. PubMed PMID: 28390159
  • Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL. Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2016 Dec 27. [Epub ahead of print] PubMed PMID: 28027587
  • Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013;8(8):e73644. PubMed PMID: 23991203
  • Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC, Childhood Liver Disease Research and Education Network. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective north american multicenter study. Hepatology. 2013 Nov;58(5):1724-31. PubMed PMID: 23703680
  • Tucker RM, Feldman AG, Fenner EK, Mack CL. Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol. 2013 Oct;59(4):790-6. PubMed PMID: 23685050
  • Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary Atresia. Springerplus. 2013 Dec;2(1):42. PubMed PMID: 23505615
  • Feldman AG, Mack CL. Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg. 2012 Aug;21(3):192-200. PubMed PMID: 22800972
  • Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):838-55. PubMed PMID: 22487950
  • Tucker RM, Mack CL. Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease. Hepatol Res. 2012 May;42(5):502-7. PubMed PMID: 22236071
  • Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012 Apr;55(4):1130-8. PubMed PMID: 22105891
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Professional Memberships

  • American Association for the Study of Liver Disease, Member
  • North American Society for Pediatric Gastroenterology, Hepatology and Nutrition , Member
  • Society For Pediatric Research (SPR), Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Gastroenterology, Board Certification (2005)
  • Pediatrics, Board Certification (2002)
  • Pediatric Transplant Hepatology, Board Certification (2006)
Conditions & Treatments
  • Digestive System
  • Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
  • Digestive System - Hepatology (Liver Disorders)
  • Digestive System - Irritable Bowel Syndrome (IBS)
  • Digestive System - Surgical Endoscopy
  • Digestive System - Therapeutic Endoscopy
Clinical Interest for Patients
I am interested in neonatal and childhood liver diseases, autoimmune-mediated intestinal and liver disease and pediatric liver transplantation.

Care Philosophy
I strive to offer excellent comprehensive care in the treatment of children with intestinal, pancreas and liver diseases. I also make it a priority to update families as new, cutting edge therapies become available.

Personal Interests
In my free time I enjoy spending time with family, running, biking and skiing.

Volunteer Activities
I participate in at least one fund raising event for Children's Hospital, Organ Donor Alliance or American Liver Foundation. I am part of a group that makes lunches for the homeless in Denver once a month.

General Information

Medical Schools:
  • MD, Loyola University Chicago Stritch School of Medicine (1992)
Undergraduate Schools:
  • BS, University of Wisconsin–Madison (WI) (1986)
Internships:
  • University of Chicago/Comer Children's Hospital Program (1993)
Residency Programs:
  • University of Chicago/Comer Children's Hospital Program, Chief Resident, Pediatrics (1996)
Fellowships:
  • McGaw Medical Center of Northwestern University/Children's Memorial Hospital Program, Pediatric Gastroenterology (2001)
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Languages: English
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition
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