Chris Silliman, MD, PhD
Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

Photo
Medical School:
  • MD, Tulane University School of Medicine (1985)
Graduate School :
  • PhD, Tulane University (1987)
Undergraduate School:
  • BS, Haverford College in Pennsylvania (PA) (1981)
Internship:
  • University of Virginia Program (1987)
Residency:
  • University of Virginia Program, Pediatrics (1989)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Hematology / Oncology (1992)
Languages: English
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation

Professional Titles

  • Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation
  • Professor
  • Senior Independent Investigator
  • Head Clinical Competency Committee
  • Associate Director HOB Fellowship

Research Interests

Transfusion Medicine Sickle Cell Anemia ITP and General Hematology Polycythemia

Teaching

  • T32 Faculty (Surgery) (2000)
    School of Medicine, Surgery
    Since 2000, I have instructed and mentored surgical research fellows in basic science, including: experimental design, data analysis, the scientific method, and writing: both publications and grants.
  • Associate Fellowship Director (HOB) (2015)
    School of Medicine, Pediatrics
    Since 2015 I have advised the HOB fellows with regard to finding a lab, making the most of their research time, publishing, and finding a job.

Publications

  • Loi MM, Kelher M, Dzieciatkowska M, Hansen KC, Banerjee A, West FB, Stanley C, Briel M, Silliman CC. A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil-priming activity during storage. Transfusion. 2018 Aug;58(8):2003-2012. PubMed PMID: 30171813
  • Stettler GR, Sumislawski JJ, Moore EE, Nunns GR, Kornblith LZ, Conroy AS, Callcut RA, Silliman CC, Banerjee A, Cohen MJ, Sauaia A. Citrated Kaolin Thrombelastography (TEG) Thresholds for Goal-Directed Therapy in Injured Patients Receiving Massive Transfusion. J Trauma Acute Care Surg. 2018 Jul 27. [Epub ahead of print] PubMed PMID: 30059456
  • Moore HB, Moore EE, Chapman MP, McVaney K, Bryskiewicz G, Blechar R, Chin T, Burlew CC, Pieracci F, West FB, Fleming CD, Ghasabyan A, Chandler J, Silliman CC, Banerjee A, Sauaia A. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet. 2018 Jul 28;392(10144):283-291. PubMed PMID: 30032977
  • Nunns GR, Stringham JR, Gamboni F, Moore EE, Fragoso M, Stettler GR, Silliman CC, Banerjee A. Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. J Surg Res. 2018 Sep;229:262-270. PubMed PMID: 29936999
  • Stettler GR, Moore EE, Nunns GR, Chandler J, Peltz E, Silliman CC, Banerjee A, Sauaia A. Rotational thromboelastometry thresholds for patients at risk for massive transfusion. J Surg Res. 2018 Aug;228:154-159. PubMed PMID: 29907206
  • Coleman JR, Moore EE, Chapman MP, Banerjee A, Silliman CC, Ghasabyan A, Chandler J, Samuels JM, Sauaia A. Rapid TEG efficiently guides hemostatic resuscitation in trauma patients. Surgery. 2018 Sep;164(3):489-493. PubMed PMID: 29903508
  • Nunns GR, Moore EE, Stettler GR, Moore HB, Ghasabyan A, Cohen M, Huebner BR, Silliman CC, Banerjee A, Sauaia A. Empiric transfusion strategies during life-threatening hemorrhage. Surgery. 2018 Aug;164(2):306-311. PubMed PMID: 29709368
  • Kuldanek S, Silliman CC. Mortality after red blood cell transfusions from previously pregnant donors: complexities in the interpretation of large data. J Thorac Dis. 2018 Feb;10(2):648-652. PubMed PMID: 29608196
  • Huebner BR, Moore EE, Moore HB, Gonzalez E, Kelher MR, Sauaia A, Banerjee A, Silliman CC. Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium. J Surg Res. 2018 May;225:1-5. PubMed PMID: 29605018
  • Banerjee A, Silliman CC, Moore EE, Dzieciatkowska M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K. Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma. J Trauma Acute Care Surg. 2018 Jun;84(6):929-938. PubMed PMID: 29554044
  • Weisberg SP, Shaz BH, Tumer G, Silliman CC, Kelher MR, Cohn CS. PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets. Transfusion. 2018 Apr;58(4):891-895. PubMed PMID: 29473178
  • Reisz JA, Wither MJ, Moore EE, Slaughter AL, Moore HB, Ghasabyan A, Chandler J, Schaub LJ, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D'alessandro A. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock: A comparison in rodents, swine, non-human primates and injured patients. J Trauma Acute Care Surg. 2017 Nov 3. [Epub ahead of print] PubMed PMID: 29112093
  • Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock and Resuscitation in a Rat Model. Shock. 2017 Jul 19. [Epub ahead of print] PubMed PMID: 28727610
  • Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Oct 5. [Epub ahead of print] PubMed PMID: 29021098
  • Stettler GR, Moore EE, Moore HB, Nunns GR, Huebner BR, Einersen P, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion. Surgery. 2017 Sep 27. [Epub ahead of print] PubMed PMID: 28964508
  • Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Sep 18. [Epub ahead of print] PubMed PMID: 28951066
  • Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017 Sep 6. [Epub ahead of print] PubMed PMID: 28880373
  • Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human Neutrophil Elastase Mediates Fibrinolysis Shutdown Through Competitive Degradation of Plasminogen and Generation of Angiostatin. J Trauma Acute Care Surg. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28837538
  • Warner MA, Welsby IJ, Norris PJ, Silliman CC, Armour S, Wittwer ED, Santrach PJ, Meade LA, Liedl LM, Nieuwenkamp CM, Douthit B, van Buskirk CM, Schulte PJ, Carter RE, Kor DJ. Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ Open. 2017 Aug 18;7(8):e016398. PubMed PMID: 28821525
  • Moore HB, Moore EE, Huebner BR, Stettler GR, Nunns GR, Einersen PM, Silliman CC, Sauaia A. Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis. J Surg Res. 2017 May 8. [Epub ahead of print] PubMed PMID: 28755903
  • Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock and Resuscitation in a Rat Model. Shock. 2017 Jul 19. [Epub ahead of print] PubMed PMID: 28727610
  • D'Alessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma Acute Care Surg. 2017 Sep;83(3):491-495. PubMed PMID: 28590356
  • Stettler GR, Moore EE, Moore HB, Lawson PJ, Fragoso M, Nunns GR, Silliman CC, Banerjee A. Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy. J Surg Res. 2017 Sep;217:207-212. PubMed PMID: 28583756
  • Moore HB, Moore EE, Chapman MP, Huebner BR, Einersen PM, Oushy S, Silliman CC, Banerjee A, Sauaia A. Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes. J Am Coll Surg. 2017 Jul;225(1):138-147. PubMed PMID: 28522144
  • Huebner BR, Moore EE, Moore HB, Sauaia A, Stettler G, Dzieciatkowska M, Hansen K, Banerjee A, Silliman CC. Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma. Transfusion. 2017 Aug;57(8):2007-2015. PubMed PMID: 28500652
  • Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, D'Alessandro A. Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine. J Trauma Acute Care Surg. 2017 Oct;83(4):635-642. PubMed PMID: 28463938
  • Yoshida T, Blair A, D'alessandro A, Nemkov T, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017 Mar;15(2):172-181. PubMed PMID: 28263176
  • Silliman CC, Burke T, Kelher MR. The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration. Blood Transfus. 2017 Mar;15(2):131-136. PubMed PMID: 28263170
  • Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, Banerjee A, Sauaia A. Rapid-thrombelastography (r-TEG) thresholds for goal-directed resuscitation of patients at risk for massive transfusion. J Trauma Acute Care Surg. 2016 Oct 31. [Epub ahead of print] PubMed PMID: 27805995
  • Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2016 Aug 16. [Epub ahead of print] PubMed PMID: 27531930
  • Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A. Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats. Blood Adv. 2017 Jul 25;1(17):1296-1305. PubMed PMID: 29296771
  • Huebner BR, Moore EE, Moore HB, Stettler GR, Nunns GR, Lawson P, Sauaia A, Kelher M, Banerjee A, Silliman CC. Thrombin Provokes Degranulation of Platelet a-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1). Shock. 2017 Dec 26. [Epub ahead of print] PubMed PMID: 29280928
  • Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017;12(12):e0189536. PubMed PMID: 29253007
  • Moore HB, Moore EE, Huebner BR, Dzieciatkowska M, Stettler GR, Nunns GR, Lawson PJ, Ghasabyan A, Chandler J, Banerjee A, Silliman C, Sauaia A, Hansen KC. Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator. J Trauma Acute Care Surg. 2017 Dec;83(6):1014-1022. PubMed PMID: 29190254
  • Lawson PJ, Moore HB, Moore EE, Stettler GR, Pshak TJ, Kam I, Silliman CC, Nydam TL. Preoperative thrombelastography maximum amplitude predicts massive transfusion in liver transplantation. J Surg Res. 2017 Dec;220:171-175. PubMed PMID: 29180179
  • Huebner BR, Moore EE, Moore HB, Shepherd-Singh R, Sauaia A, Stettler GR, Nunns GR, Silliman CC. 14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis. J Surg Res. 2017 Nov;219:145-150. PubMed PMID: 29078874
  • Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Oct 5. [Epub ahead of print] PubMed PMID: 29021098
  • Stettler GR, Moore EE, Moore HB, Nunns GR, Huebner BR, Einersen P, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion. Surgery. 2017 Sep 27. [Epub ahead of print] PubMed PMID: 28964508
  • Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Sep 18. [Epub ahead of print] PubMed PMID: 28951066
  • Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017 Sep 6. [Epub ahead of print] PubMed PMID: 28880373
  • Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human Neutrophil Elastase Mediates Fibrinolysis Shutdown Through Competitive Degradation of Plasminogen and Generation of Angiostatin. J Trauma Acute Care Surg. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28837538
  • Moore HB, Moore EE, Huebner BR, Stettler GR, Nunns GR, Einersen PM, Silliman CC, Sauaia A. Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis. J Surg Res. 2017 May 8. [Epub ahead of print] PubMed PMID: 28755903
  • Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, Banerjee A, Sauaia A. Rapid-thrombelastography (r-TEG) thresholds for goal-directed resuscitation of patients at risk for massive transfusion. J Trauma Acute Care Surg. 2016 Oct 31. [Epub ahead of print] PubMed PMID: 27805995
  • Kelher MR, Banerjee A, Gamboni F, Anderson C, Silliman CC. Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model. Transfusion. 2016 Sep 25. [Epub ahead of print] PubMed PMID: 27667662
  • Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon A, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 Sep 16. [Epub ahead of print] PubMed PMID: 27602903
  • Kelher MR, Banerjee A, Gamboni F, Anderson C, Silliman CC. Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model. Transfusion. 2016 Sep 25. [Epub ahead of print] PubMed PMID: 27667662
  • Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon A, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 Sep 16. [Epub ahead of print] PubMed PMID: 27602903
  • Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2016 Aug 16. [Epub ahead of print] PubMed PMID: 27531930
  • D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. Blood Transfus. 2016 May;14(2):185-94. PubMed PMID: 27177401
  • Kent MW, Kelher MR, Silliman CC, Quinones R. Neutrophil function in children following allogeneic hematopoietic stem cell transplant. Pediatr Transplant. 2016 Aug;20(5):658-66. PubMed PMID: 27114335
  • Moore EE, Moore HB, Gonzalez E, Sauaia A, Banerjee A, Silliman CC. Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion. 2016 Apr;56 Suppl 2:S110-4. PubMed PMID: 27100746
  • D'Alessandro A, Moore HB, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. Shock. 2016 Feb 6. [Epub ahead of print] PubMed PMID: 26863033
  • Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, Burlew CC, Johnson JL, Pieracci FM, Jurkovich GJ, Banerjee A, Silliman CC, Sauaia A. Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays. Ann Surg. 2015 Dec 28. [Epub ahead of print] PubMed PMID: 26720428
  • D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb;108(2):131-40. PubMed PMID: 25200932
  • Moore HB, Moore EE, Gonzalez E, Hansen KC, Dzieciatkowska M, Chapman MP, Sauaia A, West B, Banerjee A, Silliman CC. Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury. Shock. 2015 Jan;43(1):39-46. PubMed PMID: 25072794
  • Chapman MP, Moore EE, Moore HB, Gonzalez E, Gamboni F, Chandler JG, Mitra S, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients. J Trauma Acute Care Surg. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26491796
  • Chapman MP, Moore EE, Moore HB, Gonzalez E, Morton AP, Chandler J, Fleming CD, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. The "Black Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis. J Trauma Acute Care Surg. 2015 Oct 19. [Epub ahead of print] PubMed PMID: 26488324
  • Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D'Alessandro A, Hansen KC, Sauaia A, Banerjee A, Silliman CC. Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients. J Thromb Haemost. 2015 Oct;13(10):1878-87. PubMed PMID: 26256459
  • D'Alessandro A, Slaughter AL, Peltz ED, Moore EE, Silliman CC, Wither M, Nemkov T, Bacon AW, Fragoso M, Banerjee A, Hansen KC. Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. J Transl Med. 2015 Aug 5;13:253. PubMed PMID: 26242576
  • Harr JN, Moore EE, Chin TL, Chapman MP, Ghasabyan A, Stringham JR, Banerjee A, Silliman CC. Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. Eur J Trauma Emerg Surg. 2015 Feb;41(1):49-56. PubMed PMID: 26038165
  • Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, Silliman CC, Banerjee A. Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid. J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S65-9. PubMed PMID: 26002266
  • Moore HB, Moore EE, Lawson PJ, Gonzalez E, Fragoso M, Morton AP, Gamboni F, Chapman MP, Sauaia A, Banerjee A, Silliman CC. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery. 2015 Aug;158(2):386-92. PubMed PMID: 25979440
  • Bock A, Tucker N, Kelher MR, Khan SY, Gonzalez E, Wohlauer M, Hansen K, Dzieciatkowska M, Sauaia A, Banerjee A, Moore EE, Silliman CC. a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2. Shock. 2015 Aug;44(2):137-42. PubMed PMID: 25944790
  • D'Alessandro A, Moore HB, Moore EE, Wither M, Nemkov T, Gonzalez E, Slaughter A, Fragoso M, Hansen KC, Silliman CC, Banerjee A. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15;308(12):R1034-44. PubMed PMID: 25876652
  • Peltz ED, D'Alessandro A, Moore EE, Chin T, Silliman CC, Sauaia A, Hansen KC, Banerjee A. Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg. 2015 Apr;78(4):742-51. PubMed PMID: 25807403
  • Chapman MP, Moore EE, Chin TL, Ghasabyan A, Chandler J, Stringham J, Gonzalez E, Moore HB, Banerjee A, Silliman CC, Sauaia A. Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock. Shock. 2015 Aug;44 Suppl 1:63-70. PubMed PMID: 25784527
  • D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2014 Dec 30. [Epub ahead of print] PubMed PMID: 25556331
  • Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2014 Sep 6;112C:190-209. [Epub ahead of print] PubMed PMID: 25201077
  • D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb;108(2):131-40. PubMed PMID: 25200932
  • Moore HB, Moore EE, Gonzalez E, Hansen KC, Dzieciatkowska M, Chapman MP, Sauaia A, West B, Banerjee A, Silliman CC. Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury. Shock. 2015 Jan;43(1):39-46. PubMed PMID: 25072794
  • Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014 Dec;77(6):811-7; discussion 817. PubMed PMID: 25051384
  • Gamboni F, Escobar GA, Moore EE, Dzieciatkowska M, Hansen KC, Mitra S, Nydam TA, Silliman CC, Banerjee A. Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome. Physiol Rep. 2014 Jul 1;2(7). PubMed PMID: 24994893
  • Gonzalez E, Moore EE, Moore HB, Chapman MP, Silliman CC, Banerjee A. Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research. Scand J Surg. 2014 Apr 30;103(2):89-103. [Epub ahead of print] PubMed PMID: 24786172
  • Kent MW, Kelher MR, West FB, Silliman CC. The pro-inflammatory potential of microparticles in red blood cell units. Transfus Med. 2014 Jun;24(3):176-81. PubMed PMID: 24786047
  • Stringham JR, Moore EE, Gamboni F, Harr JN, Fragoso M, Chin TL, Carr CE, Silliman CC, Banerjee A. Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock. J Trauma Acute Care Surg. 2014 May;76(5):1214-21. PubMed PMID: 24747451
  • D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2014 Dec 30. [Epub ahead of print] PubMed PMID: 25556331
  • Wright FL, Gamboni F, Moore EE, Nydam TL, Mitra S, Silliman CC, Banerjee A. Hyperosmolarity invokes distinct anti-inflammatory mechanisms in pulmonary epithelial cells: evidence from signaling and transcription layers. PLoS One. 2014;9(12):e114129. PubMed PMID: 25479425
  • Dzieciatkowska M, D'Alessandro A, Moore EE, Wohlauer M, Banerjee A, Silliman CC, Hansen KC. Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients. Shock. 2014 Dec;42(6):485-98. PubMed PMID: 25243428
  • D'Alessandro A, Dzieciatkowska M, Peltz ED, Moore EE, Jordan JR, Silliman CC, Banerjee A, Hansen KC. Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry. Shock. 2014 Dec;42(6):509-17. PubMed PMID: 25243424
  • Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2014 Sep 6;112C:190-209. [Epub ahead of print] PubMed PMID: 25201077
  • Silliman CC, Kelher MR, Khan SY, LaSarre M, West FB, Land KJ, Mish B, Ceriano L, Sowemimo-Coker S. Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo. Blood. 2014 May 29;123(22):3488-95. PubMed PMID: 24747436
  • Kent MW, Oliveira JL, Hoyer JD, Swanson KC, Kluge ML, Dawson DB, Liang X, Winkler TJ, Breaux CW Jr, Lacount R, Silliman CC. Hb Grand Junction (HBB: c.348_349delinsG; p.His117IlefsX42): A New Hyperunstable Hemoglobin Variant. Hemoglobin. 2014;38(1):8-12. PubMed PMID: 24432801
  • Silliman CC, Bercovitz RS, Khan SY, Kelher MR, Lasarre M, Land KJ, Sowemimo-Coker S. Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury. Vox Sang. 2013 Dec 30. [Epub ahead of print] PubMed PMID: 24372341
  • Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Sauaia A, Banerjee A, Silliman CC. Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis. Shock. 2014 Jan;41(1):33-9. PubMed PMID: 24351527
  • Moore EE, Chin TL, Chapman MC, Gonzalez E, Moore HB, Silliman CC, Hansen KC, Sauaia A, Banerjee A. Plasma First in the Field for Postinjury Hemorrhagic Shock. Shock. 2013 Dec 5. [Epub ahead of print] PubMed PMID: 24317352
  • Maloney JP, Ambruso DR, Voelkel NF, Silliman CC. Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury. J Pulm Respir Med. 2014;4. PubMed PMID: 25705568
  • Morton AP, Moore EE, Wohlauer MV, Lo K, Silliman CC, Burlew CC, Banerjee A. Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?. J Surg Res. 2013 Jan;179(1):5-9. PubMed PMID: 23138049
  • Vetlesen A, Mirlashari MR, Akkök CA, Kelher MR, Khan SY, Silliman CC, Kjeldsen-Kragh J. Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates. Transfusion. 2013 Jan;53(1):147-55. PubMed PMID: 22563732
  • Ramos CR, Moore EE, Manco-Johnson ML, Silliman CC, Chapman MC, Banerjee A. The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal. J Thromb Haemost. 2013 Jul;11(7):1435-7. PubMed PMID: 23593973
  • Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg. 2013 Mar;74(3):756-62; discussion 762-5. PubMed PMID: 23425732
  • Ng C, Silliman CC, Pearl G, Smith W, Manco-Johnson M, Wang M. Treatment of refractory hemorrhage with Factor XIII in a patient with hemophilia A with inhibitor. Pediatr Blood Cancer. 2013 Jul;60(7):E23-5. PubMed PMID: 23382082
  • Lo KK, Bey EA, Patra B, Benson DD, Boothman DA, Silliman CC, Barnett CC Jr. Hemoglobin-based oxygen carrier mitigates transfusion-mediated pancreas cancer progression. Ann Surg Oncol. 2013 Jun;20(6):2073-7. PubMed PMID: 23328973
  • Harr JN, Moore EE, Johnson J, Chin TL, Wohlauer MV, Maier R, Cuschieri J, Sperry J, Banerjee A, Silliman CC, Sauaia A. Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients. Crit Care Med. 2013 Feb;41(2):399-404. PubMed PMID: 23263579
  • Morton AP, Moore EE, Wohlauer MV, Lo K, Silliman CC, Burlew CC, Banerjee A. Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?. J Surg Res. 2013 Jan;179(1):5-9. PubMed PMID: 23138049
  • Lee L, Moore EE, Hansen KC, Silliman CC, Chandler JG, Banerjee A. It's not your grandfather's field plasma. Surgery. 2012 Nov 1. [Epub ahead of print] PubMed PMID: 23122899
  • Vetlesen A, Mirlashari MR, Akkök CA, Kelher MR, Khan SY, Silliman CC, Kjeldsen-Kragh J. Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates. Transfusion. 2013 Jan;53(1):147-55. PubMed PMID: 22563732
  • Lee L, Moore EE, Hansen KC, Silliman CC, Chandler JG, Banerjee A. It's not your grandfather's field plasma. Surgery. 2012 Nov 1. [Epub ahead of print] PubMed PMID: 23122899
  • Silliman CC, Chaffin DJ. Broken hearts and transfusion-related acute lung injury. Crit Care Med. 2012 Oct;40(10):2909-10. PubMed PMID: 22986660
  • Silliman CC. PLADO and kids: earlier/increased bleeding after HSCT. Blood. 2012 Jul 26;120(4):704-5. PubMed PMID: 22835886
  • Harr JN, Moore EE, Stringham J, Wohlauer MV, Fragoso M, Jones WL, Gamboni F, Silliman CC, Banerjee A. Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition. Surgery. 2012 Aug;152(2):270-6. PubMed PMID: 22828148
  • Wohlauer M, Moore EE, Silliman CC, Fragoso M, Gamboni F, Harr J, Accurso F, Wright F, Haenel J, Fullerton D, Banerjee A. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53. PubMed PMID: 22732292
  • Ellison MA, Ambruso DR, Silliman CC. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Curr Pharm Des. 2012;18(22):3255-9. PubMed PMID: 22621271
  • Silliman CC, Kelher M, Ambruso DR. Bioactive lipids from stored cellular blood components: in vitro method is crucial for proper interpretation. Transfusion. 2012 May;52(5):1155-7; author reply 1157-8. PubMed PMID: 22571364
  • Pieracci FM, Barnett CC Jr, Townsend N, Moore EE, Johnson J, Biffl W, Bensard DD, Burlew CC, Gerber A, Silliman CC. Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients. ISRN Hematol. 2012;2012:298345. PubMed PMID: 22536521
  • Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg. 2012 May;214(5):739-46. PubMed PMID: 22520693
  • Reesink HW, Lee J, Keller A, Dennington P, Pink J, Holdsworth R, Schennach H, Goldman M, Petraszko T, Sun J, Meng Y, Qian K, Rehacek V, Turek P, Krusius T, Juvonen E, Tiberghien P, Legrand D, Semana G, Muller JY, Bux J, Reil A, Lin CK, Daly H, McSweeney E, Porretti L, Greppi N, Rebulla P, Okazaki H, Sánchez-Guerrero SA, Baptista-González HA, Martínez-Murillo C, Guerra-Márquez A, Rodriguez-Moyado H, Middelburg RA, Wiersum-Osselton JC, Brand A, van Tilburg C, Dinesh D, Dagger J, Dunn P, Brojer E, Letowska M, Maslanka K, Lachert E, Uhrynowska M, Zhiburt E, Palfi M, Berlin G, Frey BM, Puig Rovira L, Muñiz-Diaz E, Castro E, Chapman C, Green A, Massey E, Win N, Williamson L, Silliman CC, Chaffin DJ, Ambruso DR, Blumberg N, Tomasulo P, Land KJ, Norris PJ, Illoh OC, Davey RJ, Benjamin RJ, Eder AF, McLaughlin L, Kleinman S, Panzer S. Measures to prevent transfusion-related acute lung injury (TRALI). Vox Sang. 2012 Oct;103(3):231-59. PubMed PMID: 22519920
  • Tung JP, Fraser JF, Nataatmadja M, Colebourne KI, Barnett AG, Glenister KM, Zhou AY, Wood P, Silliman CC, Fung YL. Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Crit Care. 2012 Feb 1;16(1):R19. PubMed PMID: 22297161
  • Benson DD, Beck AW, Burdine MS, Brekken R, Silliman CC, Barnett CC Jr. Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. J Gastrointest Surg. 2012 Mar;16(3):460-8. PubMed PMID: 22246854
  • Bercovitz RS, Kelher MR, Khan SY, Land KJ, Berry TH, Silliman CC. The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance. Vox Sang. 2012 May;102(4):345-53. PubMed PMID: 22092073
  • Pezold M, Moore EE, Wohlauer M, Sauaia A, Gonzalez E, Banerjee A, Silliman CC. Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes. Surgery. 2012 Jan;151(1):48-54. PubMed PMID: 21899867
  • Silliman CC, Dzieciatkowska M, Moore EE, Kelher MR, Banerjee A, Liang X, Land KJ, Hansen KC. Proteomic analyses of human plasma: Venus versus Mars. Transfusion. 2012 Feb;52(2):417-24. PubMed PMID: 21880043
  • Lee L, Kelher MR, Moore EE, Banerjee A, Silliman CC. Hypertonic saline inhibits arachidonic acid priming of the human neutrophil oxidase. J Surg Res. 2012 May 1;174(1):24-8. PubMed PMID: 21816415
  • Ball JB, Khan SY, McLaughlin NJ, Kelher MR, Nuss R, Cole L, Liang X, Silliman CC. A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2 and neutrophils. Pediatr Blood Cancer. 2012 Mar;58(3):399-405. PubMed PMID: 21793188
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Professional Memberships

  • American Academy of Pediatrics (AAP), Fellow
  • American Medical Association, Member
  • American Association for the Advancement of Science, Member
  • American Society of Hematology, Member
  • American Association of Blood Banks, Member
  • American Physiological Society, Member
  • Federation of American Society for Experimental Biology, Member
  • Society for Leukocyte Biology, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hemophilia & Thrombosis Center
13199 E. Montview Blvd
Suite 100
Aurora, CO 80045
303-724-0724

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatric Hematology / Oncology, Board Certification (1992)
Conditions & Treatments
  • Blood / Lymphatic System - Blood Disorders
  • Cancers
  • Blood / Lymphatic System - Bleeding Disorders
  • Cancers - Pediatric Cancer
  • Blood / Lymphatic System
Clinical Interests
My clinical interests are General Pediatric Hematology and Oncology and Transfusion Medicine,

Care Philosophy
To accurately and quickly diagnose and treat all children with clinical hematology and Oncology diagnoses tempering all patient and patient family contacts with good humor and respect.

Personal Interests
Hobbies: reading, working out, camping, studying history

General Information

Medical Schools:
  • MD, Tulane University School of Medicine (1985)
Graduate Schools:
  • PhD, Tulane University (1987)
Undergraduate Schools:
  • BS, Haverford College in Pennsylvania (PA) (1981)
Internships:
  • University of Virginia Program (1987)
Residency Programs:
  • University of Virginia Program, Pediatrics (1989)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Hematology / Oncology (1992)
Languages: English
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation
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