Yimu Yang, MD, PhD
Assistant Research Professor, Medicine-Pulmonary Sciences & Critical Care


  • Yang Y, Nishimura H, Yang Y. Bird aquaporins: Molecular machinery for urine concentration. Biochim Biophys Acta Biomembr. 2021 Oct 1;1863(10):183688. PubMed PMID: 34242632
  • Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2021 Dec 7. [Epub ahead of print] PubMed PMID: 34874923
  • LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1198-L1210. PubMed PMID: 32320623
  • Yang Y, Hippensteel JA, Schmidt EP. Intravital Microscopy in the Mouse Lung. Methods Mol Biol. 2018;1809:331-339. PubMed PMID: 29987798
  • Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 Sep;59(3):363-374. PubMed PMID: 29584451
  • Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 Feb 10. [Epub ahead of print] PubMed PMID: 28187268
  • Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 Jun;56(6):727-737. PubMed PMID: 28187268
  • Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP. Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. Shock. 2017 Dec;48(6):666-673. PubMed PMID: 28538085
  • Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F553-F559. PubMed PMID: 28515178
  • Haeger SM, Yang Y, Schmidt EP. Heparan Sulfate in the Developing, Healthy, and Injured Lung. Am J Respir Cell Mol Biol. 2016 Jul;55(1):5-11. PubMed PMID: 26982577
  • Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49. PubMed PMID: 26926297
  • Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The Circulating Glycosaminoglycan Signature of Respiratory Failure in Critically Ill Adults. J Biol Chem. 2014 Feb 7. [Epub ahead of print] PubMed PMID: 24509853
  • Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep;184(9):2382-9. PubMed PMID: 25016184
  • Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21;289(12):8194-202. PubMed PMID: 24509853
  • Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov;1(6):e00153. PubMed PMID: 24400155
  • Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013;8(11):e79037. PubMed PMID: 24265742
  • Nishimura H, Yang Y. Aquaporins in avian kidneys: function and perspectives. Am J Physiol Regul Integr Comp Physiol. 2013 Dec;305(11):R1201-14. PubMed PMID: 24068044
  • Yang Y, Yang G, Schmidt EP. In vivo measurement of the mouse pulmonary endothelial surface layer. J Vis Exp. 2013 Feb 22;(72):e50322. PubMed PMID: 23462690
  • Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013 Jan 1;1(1). PubMed PMID: 24073386
  • Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug;18(8):1217-23. PubMed PMID: 22820644
  • Ruiz-Feria CA, Yang Y, Thomason DB, White J, Su G, Nishimura H. Pulse wave velocity and age- and gender-dependent aortic wall hardening in fowl. Comp Biochem Physiol A Mol Integr Physiol. 2009 Dec;154(4):429-36. PubMed PMID: 19689927
  • Lau KK, Yang Y, Cook GA, Wyatt RJ, Nishimura H. Control of aquaporin 2 expression in collecting ducts of quail kidneys. Gen Comp Endocrinol. 2009 Feb 1;160(3):288-94. PubMed PMID: 19135443
  • Nishimura H, Yang Y, Lau K, Kuykindoll RJ, Fan Z, Yamaguchi K, Yamamoto T. Aquaporin-2 water channel in developing quail kidney: possible role in programming adult fluid homeostasis. Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2147-58. PubMed PMID: 17699563
  • Yang Y, Cui Y, Fan Z, Cook GA, Nishimura H. Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney. Comp Biochem Physiol A Mol Integr Physiol. 2007 May;147(1):84-93. PubMed PMID: 17303458
  • Ruiz-Feria CA, Yang Y, Nishimura H. Do incremental increases in blood pressure elicit neointimal plaques through endothelial injury?. Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1486-93. PubMed PMID: 15319217
  • Yang Y, Cui Y, Wang W, Zhang L, Bufford L, Sasaki S, Fan Z, Nishimura H. Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney. Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R915-24. PubMed PMID: 15205186
  • Nishimura H, Yang Y, Hubert C, Gasc JM, Ruijtenbeek K, De Mey J, Boudier HA, Corvol P. Maturation-dependent changes of angiotensin receptor expression in fowl. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R231-42. PubMed PMID: 12702485
  • Yang Y, Ozawa H, Yuri K, Kawata M. Postnatal development of NADPH-diaphorase activity in the rat: the role of nitric oxide in the ontogeny of arginine vasopression and oxytocin. Endocr J. 2000 Oct;47(5):601-13. PubMed PMID: 11200942
  • Xie CX, Ozawa H, Yang YM, Kawata M. Immunohistochemical study of nucleoporin p62 in the hippocampus and hypothalamus of the rat brain. Neuroreport. 2000 Sep 11;11(13):2965-7. PubMed PMID: 11006975
  • Yang Y, Ozawa H, Lu H, Yuri K, Hayashi S, Nihonyanagi K, Kawata M. Immunocytochemical analysis of sex differences in calcitonin gene-related peptide in the rat dorsal root ganglion, with special reference to estrogen and its receptor. Brain Res. 1998 Apr 27;791(1-2):35-42. PubMed PMID: 9593813
  • Hu Z, Yuri K, Ozawa H, Lu H, Yang Y, Ito T, Kawata M. Adrenalectomy-induced granule cell death is predicated on the disappearance of glucocorticoid receptor immunoreactivity in the rat hippocampal granule cell layer. Brain Res. 1997 Dec 19;778(2):293-301. PubMed PMID: 9459546
  • Yang Y, Yuri K, Matsuura T, Ozawa H, Kawata M. The effects of nerve growth factor on newborn rat dorsal root ganglion neurons in vitro: a scanning electron microscopic observation. J Hirnforsch. 1996;37(3):313-7. PubMed PMID: 8872556
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

General Information

Department: Medicine-Pulmonary Sciences & Critical Care
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CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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