Frederick Suchy, MD
Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

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Medical School:
  • MD, University of Cincinnati College of Medicine (1974)
Graduate School :
  • MA, Yale University (1989)
Undergraduate School:
  • AB, Columbia University (NY) (1970)
Internship:
  • Cincinnati Children's Hospital Medical Center Program (1975)
Residency:
  • Cincinnati Children's Hospital Medical Center Program, Pediatrics (1977)
Fellowships:
  • Cincinnati Children's Hospital Medical Center Program, Pediatric Gastroenterology (1982)
Languages: English
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition

Professional Titles

  • Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition
  • Chief Research Officer, Digestive Health

Recognition & Awards

  • America's Best Doctors, Castlle Connolly, (2016)
    also awarded 2005-2010
  • member, Association of American Physicians, (2002)
  • Member, American Society for Clinical Investigation, (1992)
Research interests for Patients:
My research focuses on pediatric liver disease, cholestasis, mechanisms of bile formation, hepatic and intestinal bile bile acid and organic anion transport, molecular and developmental regulation of liver transport mechanisms, regulation of transport proteins by nuclear receptors, inborn errors of bile acid metabolism and epithelial cell polarity.

Teaching

  • Professor (2010)
    School of Medicine, Pediatrics

Publications

  • Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC. Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. J Pediatr. 2018 Nov;202:179-185.e4. PubMed PMID: 30244988
  • Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLoS One. 2016 Jun 28;11(6):e0158269. PubMed PMID: 27351185
  • Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Nuclear factor ?B Regulates the Expression of Multiple Genes Encoding Liver Transport Proteins. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 11;:ajpgi.00363.2015. [Epub ahead of print] PubMed PMID: 26867564
  • Aguilo F, Li S, Balasubramaniyan N, Sancho A, Benko S, Zhang F, Vashisht A, Rengasamy M, Andino B, Chen CH, Zhou F, Qian C, Zhou MM, Wohlschlegel JA, Zhang W, Suchy FJ, Walsh MJ. Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1a. Cell Rep. 2016 Jan 26;14(3):479-92. PubMed PMID: 26774474
  • Suchy FJ, Ananthanarayanan M. Bile acid hepatotoxicity: Epigenetics comes to the rescue. Hepatology. 2015 Jul;62(1):22-4. PubMed PMID: 25808941
  • Suchy FJ, Ananthanarayanan M. Bile acid hepatotoxicity: Epigenetics comes to the rescue. Hepatology. 2015 Jul;62(1):22-4. PubMed PMID: 25808941
  • Sancho A, Li S, Paul T, Zhang F, Aguilo F, Vashisht A, Balasubramaniyan N, Leleiko NS, Suchy FJ, Wohlschlegel JA, Zhang W, Walsh MJ. CHD6 regulates the topological arrangement of the CFTR locus. Hum Mol Genet. 2015 May 15;24(10):2724-32. PubMed PMID: 25631877
  • Sancho A, Li S, Paul T, Zhang F, Aguilo F, Vashisht A, Balasubramaniyan N, Leleiko NS, Suchy FJ, Wohlschlegel JA, Zhang W, Walsh MJ. CHD6 regulates the topological arrangement of the CFTR locus. Hum Mol Genet. 2015 May 15;24(10):2724-32. PubMed PMID: 25631877
  • Xu S, Sun AQ, Suchy FJ. A novel RARa/CAR-mediated mechanism for regulation of human organic solute transporter-ß gene expression. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. PubMed PMID: 24264050
  • Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ, Childhood Liver Disease Research and Education Network (ChiLDREN). Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014 May 7;311(17):1750-9. PubMed PMID: 24794368
  • Xu S, Sun AQ, Suchy FJ. A novel RARa/CAR-mediated mechanism for regulation of human organic solute transporter-ß gene expression. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. PubMed PMID: 24264050
  • Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ, Childhood Liver Disease Research and Education Network (ChiLDREN). Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014 May 7;311(17):1750-9. PubMed PMID: 24794368
  • Xu S, Sun AQ, Suchy FJ. A novel RARa/CAR-mediated mechanism for regulation of human organic solute transporter-ß gene expression. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. PubMed PMID: 24264050
  • Balasubramaniyan N, Luo Y, Sun AQ, Suchy FJ. SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes. J Biol Chem. 2013 May 10;288(19):13850-62. PubMed PMID: 23546875
  • Suchy FJ. Biliary atresia in sea lampreys. What can it tell us about the disorder in human infants?. Hepatology. 2013 Jun;57(6):2114-6. PubMed PMID: 23526371
  • Sun AQ, Luo Y, Backos DS, Xu S, Balasubramaniyan N, Reigan P, Suchy FJ. Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation. Mol Pharmacol. 2013 May;83(5):1078-86. PubMed PMID: 23462506
  • Kerkar N, D'Urso C, Van Nostrand K, Kochin I, Gault A, Suchy F, Miloh T, Arnon R, Chu J, Annunziato R. Psychosocial Outcomes for Children with Nonalcoholic Fatty Liver Disease over Time and Compared to Obese Controls. J Pediatr Gastroenterol Nutr. 2012 Aug 24. [Epub ahead of print] PubMed PMID: 22925921
  • Sun AQ, Zhu L, Luo Y, Xu S, Lin J, Suchy FJ. Human Organic Solute Transporter (hOST): protein interaction and membrane sorting process. Int J Biochem Mol Biol. 2012;3(3):290-301. PubMed PMID: 23097745
  • Kerkar N, D'Urso C, Van Nostrand K, Kochin I, Gault A, Suchy F, Miloh T, Arnon R, Chu J, Annunziato R. Psychosocial Outcomes for Children with Nonalcoholic Fatty Liver Disease over Time and Compared to Obese Controls. J Pediatr Gastroenterol Nutr. 2012 Aug 24. [Epub ahead of print] PubMed PMID: 22925921
  • Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, Rosenthal P, Schwarz K, Suchy FJ, Kerkar N, Turmelle Y, Whitington PF, Robuck PR, Sokol RJ, Childhood Liver Disease Research Education Network (ChiLDREN). Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia. Pediatrics. 2012 Sep;130(3):e607-14. PubMed PMID: 22891232
  • Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldán A. miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. EMBO Mol Med. 2012 Sep;4(9):882-95. PubMed PMID: 22767443
  • Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G937-47. PubMed PMID: 22345554
  • Tomaino J, Keegan T, Miloh T, Kerkar N, Mercer S, Birge M, Rocca J, Suchy F, Arnon R. Stevens-Johnson syndrome after Mycoplasma pneumonia infection in pediatric post-liver transplant recipient: case report and review of the literature. Pediatr Transplant. 2012 May;16(3):E74-7. PubMed PMID: 21176015
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Professional Memberships

  • Association of American Physicians, Member
  • American Academy of Pediatrics (AAP), Member
  • American Pediatric Society (APS), Member
  • International Liver Transplantation Society, Member
  • Eastern Society for Pediatric Research (ESPR), Member
  • American Gastroenterological Association, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatrics, Board Certification (1982)
  • Pediatric Gastroenterology, Board Certification (1991, 2015)
  • Pediatric Transplant Hepatology, Board Certification (2006)
Clinical Interest for Patients
I am interested in neonatal cholestasis, drug-induced liver disease, viral hepatitis, metabolic liver disease, liver transplantation and acute liver failure.

General Information

Medical Schools:
  • MD, University of Cincinnati College of Medicine (1974)
Graduate Schools:
  • MA, Yale University (1989)
Undergraduate Schools:
  • AB, Columbia University (NY) (1970)
Internships:
  • Cincinnati Children's Hospital Medical Center Program (1975)
Residency Programs:
  • Cincinnati Children's Hospital Medical Center Program, Pediatrics (1977)
Fellowships:
  • Cincinnati Children's Hospital Medical Center Program, Pediatric Gastroenterology (1982)
Languages: English
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition
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