Andrew Fontenot, MD
Professor, Medicine-Allergy/Clinical Immunology

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Medical School:
  • MD, Louisiana State University School of Medicine in New Orleans (1990)
Undergraduate School:
  • BS, Louisiana State University (LA) (1986)
Internship:
  • University of Alabama Medical Center Program (1991)
Residencies:
  • University of Alabama Medical Center Program, Chief Resident, Internal Medicine (1994)
  • University of Alabama Medical Center Program, Internal Medicine (1993)
Fellowships:
  • University of Colorado (University Hospital) Program, Pulmonary Disease and Critical Care Medicine (1997)
Languages: English
Department: Medicine-Allergy/Clinical Immunology

Research Interests

My research interests include the role of T cells in the development of lung disease. I am also interested in the alterations in lung microbiome that characterize the lung in different stages of HIV disease and whether a broadened microbiome could contribute to the early onset of lung disease in HIV-infected patients.

Publications

  • Logue EC, Neff CP, Mack DG, Martin AK, Fiorillo S, Lavelle J, Vandivier RW, Campbell TB, Palmer BE, Fontenot AP. Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers. J Immunol. 2019 Jan 21. [Epub ahead of print] PubMed PMID: 30665939
  • Fontenot AP. Immunologic Effects of Beryllium Exposure. Ann Am Thorac Soc. 2018 Apr;15(Supplement_2):S81-S85. PubMed PMID: 29676647
  • Wade MF, Collins MK, Richards D, Mack DG, Martin AK, Dinarello CA, Fontenot AP, McKee AS. TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018 Oct 15;201(8):2232-2243. PubMed PMID: 30185516
  • Armstrong AJS, Shaffer M, Nusbacher NM, Griesmer C, Fiorillo S, Schneider JM, Preston Neff C, Li SX, Fontenot AP, Campbell T, Palmer BE, Lozupone CA. An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men. Microbiome. 2018 Nov 5;6(1):198. PubMed PMID: 30396369
  • Moller DR, Rybicki BA, Hamzeh NY, Montgomery CG, Chen ES, Drake W, Fontenot AP. Genetic, Immunologic, and Environmental Basis of Sarcoidosis. Ann Am Thorac Soc. 2017 Dec;14(Supplement_6):S429-S436. PubMed PMID: 29073364
  • Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Landry LG, Eklund A, Nakayama M, Slansky JE, Grunewald J, Fontenot AP. Shared aß TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome. J Immunol. 2017 Oct 1;199(7):2279-2290. PubMed PMID: 28827283
  • Presti RM, Flores SC, Palmer BE, Atkinson JJ, Lesko CR, Lau B, Fontenot AP, Roman J, McDyer JF, Twigg HL 3rd. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest. 2017 Nov;152(5):1053-1060. PubMed PMID: 28427967
  • Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 1;196(1):22-7. PubMed PMID: 26685315
  • Falta MT, Tinega AN, Mack DG, Bowerman NA, Crawford F, Kappler JW, Pinilla C, Fontenot AP. Metal-specific CD4( ) T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol. 2016 Jan;9(1):218-28. PubMed PMID: 26129650
  • McKee AS, Fontenot AP. Interplay of innate and adaptive immunity in metal-induced hypersensitivity. Curr Opin Immunol. 2016 Oct;42:25-30. PubMed PMID: 27228132
  • Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE. Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8272-7. PubMed PMID: 27307436
  • Cribbs SK, Fontenot AP. The Impact of Antiretroviral Therapy on Lung Immunology. Semin Respir Crit Care Med. 2016 Apr;37(2):157-65. PubMed PMID: 26974295
  • Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 1;196(1):22-7. PubMed PMID: 26685315
  • Falta MT, Tinega AN, Mack DG, Bowerman NA, Crawford F, Kappler JW, Pinilla C, Fontenot AP. Metal-specific CD4 T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol. 2016 Jan;9(1):218-28. PubMed PMID: 26129650
  • Beck JM, Schloss PD, Venkataraman A, Twigg H 3rd, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB. Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1335-44. PubMed PMID: 26247840
  • McKee AS, Mack DG, Crawford F, Fontenot AP. MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4? T-cell priming. Mucosal Immunol. 2015 Nov;8(6):1237-47. PubMed PMID: 25760420
  • Neff CP, Chain JL, MaWhinney S, Martin AK, Linderman DJ, Flores SC, Campbell TB, Palmer BE, Fontenot AP. Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. Am J Respir Crit Care Med. 2015 Feb 15;191(4):464-73. PubMed PMID: 25536276
  • Bowerman NA, Falta MT, Mack DG, Wehrmann F, Crawford F, Mroz MM, Maier LA, Kappler JW, Fontenot AP. Identification of Multiple Public TCR Repertoires in Chronic Beryllium Disease. J Immunol. 2014 Apr 9. [Epub ahead of print] PubMed PMID: 24719461
  • Twigg HL 3rd, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G, Lung HIV Microbiome Project. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med. 2013 Jul;1(5):354-6. PubMed PMID: 24429191
  • Fontenot AP, Peebles RS Jr. Allergy and hypersensitivity. Curr Opin Immunol. 2013 Dec;25(6):736-7. PubMed PMID: 24183163
  • Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013 Sep 11;14(3):329-39. PubMed PMID: 24034618
  • Dai S, Falta MT, Bowerman NA, McKee AS, Fontenot AP. T cell recognition of beryllium. Curr Opin Immunol. 2013 Dec;25(6):775-80. PubMed PMID: 23978481
  • Chain JL, Martin AK, Mack DG, Maier LA, Palmer BE, Fontenot AP. Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation. J Immunol. 2013 Aug 15;191(4):1648-56. PubMed PMID: 23851684
  • Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP. Identification of beryllium-dependent peptides recognized by CD4 T cells in chronic beryllium disease. J Exp Med. 2013 Jul 1;210(7):1403-18. PubMed PMID: 23797096
  • Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM, Lung HIV Microbiome Project. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013 May 15;187(10):1067-75. PubMed PMID: 23491408
  • Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP, Lung HIV Microbiome Project. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15;187(10):1110-7. PubMed PMID: 23392441
  • Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4 T cell levels in humanized mice. J Immunol. 2013 Jan 1;190(1):211-9. PubMed PMID: 23209326
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Professional Memberships

  • American Thoracic Society (ATS), Member
  • American College of Physicians (ACP), Member

Practice Locations

UCHealth Pulmonology Clinic – Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0748

UCHealth Interstitial Lung Disease Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 7th Fl
Aurora, CO 80045
720-848-0748

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1994)
  • Pulmonary Disease, Board Certification (1996)
  • Critical Care Medicine, Board Certification (1997)
Conditions & Treatments
  • Lungs and Breathing
Clinical Interests
I am interested in treating interstitial lung disease, granulomatous lung disease, and HIV disease.

General Information

Medical Schools:
  • MD, Louisiana State University School of Medicine in New Orleans (1990)
Undergraduate Schools:
  • BS, Louisiana State University (LA) (1986)
Internships:
  • University of Alabama Medical Center Program (1991)
Residency Programs:
  • University of Alabama Medical Center Program, Chief Resident, Internal Medicine (1994)
  • University of Alabama Medical Center Program, Internal Medicine (1993)
Fellowships:
  • University of Colorado (University Hospital) Program, Pulmonary Disease and Critical Care Medicine (1997)
Languages: English
Department: Medicine-Allergy/Clinical Immunology
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