Arthur Gutierrez-Hartmann, MD
Professor, Medicine-Endocrinology/Metabolism/Diabetes

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Medical School:
  • MD, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School (1975)
Undergraduate School:
  • BA, University of Texas–Austin (TX) (1971)
Internship:
  • Stanford Hospital and Clinics Program (1978)
Residency:
  • Stanford Hospital and Clinics Program, Internal Medicine (1980)
Fellowships:
  • University of California (San Francisco) Program, Endocrinology, Diabetes and Metabolism (1983)
Languages: English, Spanish
Department: Medicine-Endocrinology/Metabolism/Diabetes

Professional Titles

  • Professor, Medicine-Endocrinology/Metabolism/Diabetes
  • Professor, Departments of Medicine and of Biochemistry & Molecular Genetics
  • Director, Medical Scientist Training Program
  • Director, Physician Scientist Training Program
  • Associate Dean for Research Education

Teaching

  • Professor (1985)
    School of Medicine, Medicine
    Pathophysiology and molecular mechanisms of disease related to Endocrine disorders
  • Professor (1985)
    Graduate School, Biochemistry & Molecular Genetics
    Molecular mechanisms of Pit-1 and ETS transcription factor functions in pituitary and mammary biology and carcinogenesis.

Publications

  • Roof AK, Gutierrez-Hartmann A. Consider the context: Ras/ERK and PI3K/AKT/mTOR signaling outcomes are pituitary cell type-specific. Mol Cell Endocrinol. 2018 Mar 5;463:87-96. PubMed PMID: 28445712
  • Roof AK, Trudeau T, Gutierrez-Hartmann A. Pituitary somatolactotropes evade an oncogenic response to Ras. Mol Cell Endocrinol. 2018 Nov 15;476:165-172. PubMed PMID: 29753028
  • Roof AK, Jirawatnotai S, Trudeau T, Kuzyk C, Wierman ME, Kiyokawa H, Gutierrez-Hartmann A. The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine. Endocrinology. 2018 Jun 1;159(6):2421-2434. PubMed PMID: 29726995
  • Roof AK, Gutierrez-Hartmann A. Consider the context: Ras/ERK and PI3K/AKT/mTOR signaling outcomes are pituitary cell type-specific. Mol Cell Endocrinol. 2018 Mar 5;463:87-96. PubMed PMID: 28445712
  • Yeung TL, Leung CS, Wong KK, Gutierrez-Hartmann A, Kwong J, Gershenson DM, Mok SC. ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells. Oncotarget. 2017 Feb 9. [Epub ahead of print] PubMed PMID: 28199976
  • Kar A, Liu B, Gutierrez-Hartmann A. ESE-1 Knockdown Attenuates Growth in Trastuzumab-resistant HER2( ) Breast Cancer Cells. Anticancer Res. 2017 Dec;37(12):6583-6591. PubMed PMID: 29187433
  • Kar A, Gutierrez-Hartmann A. ESE-1/ELF3 mRNA expression associates with poor survival outcomes in HER2( ) breast cancer patients and is critical for tumorigenesis in HER2( ) breast cancer cells. Oncotarget. 2017 Sep 19;8(41):69622-69640. PubMed PMID: 29050229
  • Yeung TL, Leung CS, Wong KK, Gutierrez-Hartmann A, Kwong J, Gershenson DM, Mok SC. ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells. Oncotarget. 2017 Feb 9. [Epub ahead of print] PubMed PMID: 28199976
  • Booth AK, Gutierrez-Hartmann A. Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis. Adv Exp Med Biol. 2015;846:37-59. PubMed PMID: 25472533
  • Song KH, Fan AC, Brlansky JT, Trudeau T, Gutierrez-Hartmann A, Calvisi ML, Borden MA. High Efficiency Molecular Delivery with Sequential Low-Energy Sonoporation Bursts. Theranostics. 2015;5(12):1419-27. PubMed PMID: 26681986
  • Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini CL, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WH, Porter CC, Di Paola J. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet. 2015 Mar 25. [Epub ahead of print] PubMed PMID: 25807284
  • Booth AK, Gutierrez-Hartmann A. Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis. Adv Exp Med Biol. 2015;846:37-59. PubMed PMID: 25472533
  • Booth A, Trudeau T, Gomez C, Lucia MS, Gutierrez-Hartmann A. Persistent ERK/MAPK activation promotes lactotrope differentiation and diminishes tumorigenic phenotype. Mol Endocrinol. 2014 Dec;28(12):1999-2011. PubMed PMID: 25361391
  • Kar A, Gutierrez-Hartmann A. Molecular mechanisms of ETS transcription factor-mediated tumorigenesis. Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):522-43. PubMed PMID: 24066765
  • Kern HB, Niemeyer BF, Parrish JK, Kerr CA, Yaghi NK, Prescott JD, Gutierrez-Hartmann A, Jedlicka P. Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors. DNA Cell Biol. 2012 Aug;31(8):1403-11. PubMed PMID: 22553926
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Professional Memberships

  • Endocrine Society, Member
  • American Society of Clinical Investigation, Selected member
  • American Assocaition for Cancer Research, Member
  • American Society of Biochemistry & Molecular Biology, Member
  • Association of American Physicians, elected member

Practice Locations

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Endocrinology/Diabetes/Metabolism - Anschutz
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2650

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Endocrinology, Diabetes and Metabolism, Board Certification (1985)
Conditions & Treatments
  • Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
  • Endocrine System (Hormones) - Thyroid Cancer
  • Endocrine System (Hormones) - Thyroid Disease
  • Endocrine System (Hormones) - Adrenal Diseases
  • Endocrine System (Hormones)

General Information

Medical Schools:
  • MD, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School (1975)
Undergraduate Schools:
  • BA, University of Texas–Austin (TX) (1971)
Internships:
  • Stanford Hospital and Clinics Program (1978)
Residency Programs:
  • Stanford Hospital and Clinics Program, Internal Medicine (1980)
Fellowships:
  • University of California (San Francisco) Program, Endocrinology, Diabetes and Metabolism (1983)
Languages: English, Spanish
Department: Medicine-Endocrinology/Metabolism/Diabetes
;