Mark Petrash, PhD
Professor, Ophthalmology

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Graduate School :
  • PhD, University of Texas Medical Branch (1982)
Undergraduate School:
  • BA/BS, University of Texas–Austin (TX) (1977)
Languages: English
Department: Ophthalmology

Professional Titles

  • Professor
  • Vice Chair for Research
  • Associate Director of Gates Center

Research Interests

Drug discovery and development for cataract prevention Therapeutics against diabetic eye disease Presbyopia

Publications

  • Goswami DG, Kant R, Ammar DA, Kumar D, Enzenauer RW, Petrash JM, Tewari-Singh N, Agarwal R. Acute corneal injury in rabbits following nitrogen mustard ocular exposure. Exp Mol Pathol. 2019 Oct;110:104275. PubMed PMID: 31233733
  • Zukin LM, Pedler MG, Chyung K, Seiwald S, Lenhart P, Shieh B, Petrash JM. Aldose reductase inhibition enhances lens regeneration in mice. Chem Biol Interact. 2019 Jul 1;307:58-62. PubMed PMID: 31026421
  • Petrash JM. Editorial. Chem Biol Interact. 2019 May 25;305:11. PubMed PMID: 30898601
  • Chang KC, Shieh B, Petrash JM. Role of aldose reductase in diabetes-induced retinal microglia activation. Chem Biol Interact. 2019 Apr 1;302:46-52. PubMed PMID: 30682331
  • Chang KC, Petrash JM. Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease. Adv Exp Med Biol. 2018;1032:173-202. PubMed PMID: 30362099
  • Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ. Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2691-2705. PubMed PMID: 30354230
  • Zukin LM, Pedler MG, Groman-Lupa S, Pantcheva M, Ammar DA, Petrash JM. Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery. Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3591-3598. PubMed PMID: 30025084
  • Kalita D, Holm DG, LaBarbera DV, Petrash JM, Jayanty SS. Inhibition of a-glucosidase, a-amylase, and aldose reductase by potato polyphenolic compounds. PLoS One. 2018;13(1):e0191025. PubMed PMID: 29370193
  • Kennedy JB, Larochelle MB, Pedler MG, Petrash JM, Enzenauer RW. The effect of amniotic membrane grafting on healing and wound strength after strabismus surgery in a rabbit model. J AAPOS. 2018 Feb;22(1):22-26.e1. PubMed PMID: 29225157
  • Kennedy JB, Larochelle MB, Pedler MG, Petrash JM, Enzenauer RW. The effect of amniotic membrane grafting on healing and wound strength after strabismus surgery in a rabbit model. J AAPOS. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29225157
  • Tewari-Singh N, Goswami DG, Kant R, Ammar DA, Kumar D, Enzenauer RW, Casillas RP, Croutch CR, Petrash JM, Agarwal R. Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicol Sci. 2017 Dec 1;160(2):420-428. PubMed PMID: 28973427
  • Chang KC, Shieh B, Petrash JM. Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chem Biol Interact. 2017 Oct 1;276:149-154. PubMed PMID: 28137510
  • Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea. 2016 Feb;35(2):257-66. PubMed PMID: 26555588
  • Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM. Therapeutic potential of a-crystallin. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):252-7. PubMed PMID: 25840354
  • Diego JL, Bidikov L, Pedler MG, Kennedy JB, Quiroz-Mercado H, Gregory DG, Petrash JM, McCourt EA. Effect of human milk as a treatment for dry eye syndrome in a mouse model. Mol Vis. 2016 Sep 9;22:1095-1102. PubMed PMID: 27667918
  • Chang KC, Li L, Sanborn TM, Shieh B, Lenhart P, Ammar D, LaBarbera DV, Petrash JM. Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. J Nat Prod. 2016 May 27;79(5):1439-44. PubMed PMID: 27140653
  • Chang KC, Shieh B, Petrash JM. Aldose reductase mediates retinal microglia activation. Biochem Biophys Res Commun. 2016 Apr 29;473(2):565-71. PubMed PMID: 27033597
  • Tewari-Singh N, Croutch CR, Tuttle R, Goswami DG, Kant R, Peters E, Culley T, Ammar DA, Enzenauer RW, Petrash JM, Casillas RP, Agarwal R. Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutan Ocul Toxicol. 2016 Dec;35(4):319-28. PubMed PMID: 27002633
  • Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea. 2016 Feb;35(2):257-66. PubMed PMID: 26555588
  • Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM. Therapeutic potential of a-crystallin. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):252-7. PubMed PMID: 25840354
  • Mueller NH, Fogueri U, Pedler MG, Montana K, Petrash JM, Ammar DA. Impact of Subunit Composition on the Uptake of a-Crystallin by Lens and Retina. PLoS One. 2015;10(9):e0137659. PubMed PMID: 26355842
  • Chang KC, Petrash JM. Aldose Reductase Mediates Transforming Growth Factor ß2 (TGF-ß2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4198-210. PubMed PMID: 26132779
  • Snow A, Shieh B, Chang KC, Pal A, Lenhart P, Ammar D, Ruzycki P, Palla S, Reddy GB, Petrash JM. Aldose reductase expression as a risk factor for cataract. Chem Biol Interact. 2015 Jun 5;234:247-53. PubMed PMID: 25541468
  • Chang KC, Snow A, LaBarbera DV, Petrash JM. Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact. 2015 Jun 5;234:254-60. PubMed PMID: 25451566
  • Snow A, Shieh B, Chang KC, Pal A, Lenhart P, Ammar D, Ruzycki P, Palla S, Reddy GB, Petrash JM. Aldose reductase expression as a risk factor for cataract. Chem Biol Interact. 2014 Dec 22. [Epub ahead of print] PubMed PMID: 25541468
  • Chang KC, Snow A, LaBarbera DV, Petrash JM. Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact. 2014 Oct 18. [Epub ahead of print] PubMed PMID: 25451566
  • Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2526-38. PubMed PMID: 24876114
  • Chang KC, Ponder J, Labarbera DV, Petrash JM. Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Invest Ophthalmol Vis Sci. 2014 May 2;55(5):2853-61. PubMed PMID: 24677107
  • Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of ß-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 9;57(1):71-7. PubMed PMID: 24341381
  • Christopher KL, Pedler MG, Shieh B, Ammar DA, Petrash JM, Mueller NH. Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death. Biochim Biophys Acta. 2014 Feb;1843(2):309-15. PubMed PMID: 24275510
  • Lee CA, Li G, Patel MD, Petrash JM, Benetz BA, Veenstra A, Amengual J, von Lintig J, Burant CJ, Tang J, Kern TS. Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, rage, leukocytes, and aldose reductase. Invest Ophthalmol Vis Sci. 2014 May 2;55(5):2904-10. PubMed PMID: 23920367
  • Petrash JM. Aging and age-related diseases of the ocular lens and vitreous body. Invest Ophthalmol Vis Sci. 2013 Dec 13;54(14):ORSF54-9. PubMed PMID: 24335070
  • Yandrapu SK, Upadhyay AK, Petrash JM, Kompella UB. Nanoparticles in porous microparticles prepared by supercritical infusion and pressure quench technology for sustained delivery of bevacizumab. Mol Pharm. 2013 Dec 2;10(12):4676-86. PubMed PMID: 24131101
  • Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
  • Lee CA, Li G, Patel MD, Petrash JM, Benetz BA, Veenstra A, Amengual J, Von Lintig J, Burant C, Tang J, Kern TS. Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, RAGE, leukocytes, and aldose reductase. Invest Ophthalmol Vis Sci. 2013 Aug 6. [Epub ahead of print] PubMed PMID: 23920367
  • Tang J, Du Y, Petrash JM, Sheibani N, Kern TS. Deletion of aldose reductase from mice inhibits diabetes-induced retinal capillary degeneration and superoxide generation. PLoS One. 2013;8(4):e62081. PubMed PMID: 23614016
  • Énzsöly A, Markó K, Tábi T, Szöko É, Zelkó R, Tóth M, Petrash JM, Mátyus P, Németh J. Lack of association between VAP-1/SSAO activity and corneal neovascularization in a rabbit model. J Neural Transm. 2013 Jun;120(6):969-75. PubMed PMID: 23397320
  • Chang KC, Laffin B, Ponder J, Enzsöly A, Németh J, LaBarbera DV, Petrash JM. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact. 2013 Feb 25;202(1-3):283-7. PubMed PMID: 23247009
  • Mueller NH, Ammar DA, Petrash JM. Cell penetration peptides for enhanced entry of aB-crystallin into lens cells. Invest Ophthalmol Vis Sci. 2013 Jan 2;54(1):2-8. PubMed PMID: 23150610
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Specialty Information

Specialties
  • Ophthalmology

General Information

Graduate Schools:
  • PhD, University of Texas Medical Branch (1982)
Undergraduate Schools:
  • BA/BS, University of Texas–Austin (TX) (1977)
Download CV
Languages: English
Department: Ophthalmology
;