Ellen Burnham, MD
Professor, Medicine-Pulmonary Sciences & Critical Care

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Medical School:
  • MD, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School (1995)
Graduate School :
  • MSc, Emory University Rollins School of Public Health (2008)
Undergraduate School:
  • BS, Texas Christian University (TX) (1991)
Internship:
  • University of Texas Southwestern Medical School Program (1996)
Residency:
  • University of Texas Southwestern Medical School Program, Internal Medicine (1998)
Fellowships:
  • Emory University School of Medicine Program, Pulmonary Disease and Critical Care Medicine (2002)
Languages: English
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Professor, Medicine-Pulmonary Sciences & Critical Care
  • Director, University of Colorado Hospital Medical ICU
  • Director, Colorado Clinical and Translational Sciences Institute KL2 Program

Recognition & Awards

  • Professional Leadership Award, University of Colorado School of Medicine, Office of Women in Medicine and Science (2013)

Research Interests

I am a pulmonary and critical care physician-scientist. Our group's research focuses on the effect of alcohol and substance use on development of pneumonia and ARDS, and outcomes among these patients. Along with local and national collaborators, we have formed a consortium to enable translational investigations in this area, and have developed a biorepository to facilitate investigations. Additional research interests include methods to facilitate career development of junior faculty, including optimizing the mentor-mentee relationship to promote career success. I am the Program Director for the CCTSI's KL2 Mentored Career Development program that supports this role.

Publications

  • Tanabe J, Yamamoto DJ, Sutton B, Brown MS, Hoffman PL, Burnham EL, Glueck DH, Tabakoff B. Effects of Alcohol and Acetate on Cerebral Blood Flow: A Pilot Study. Alcohol Clin Exp Res. 2019 Oct;43(10):2070-2078. PubMed PMID: 31386214
  • Burns KEA, Burnham EL, Dodek PM, Moss M. Unconscious bias in the selection and interpretation of data on sex and burnout - Authors' reply. Lancet Respir Med. 2019 Aug;7(8):e24. PubMed PMID: 31342898
  • Prohaska CC, Sottile PD, Nordon-Craft A, Gallagher MD, Burnham EL, Clark BJ, Ho M, Kiser TH, Vandivier RW, Liu W, Schenkman M, Moss M. Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample. Crit Care. 2019 May 16;23(1):175. PubMed PMID: 31097017
  • Burnham EL, Burns KEA, Moss M, Dodek PM. Burnout in women intensivists: a hidden epidemic?. Lancet Respir Med. 2019 Apr;7(4):292-294. PubMed PMID: 30744938
  • Burnham EL, Eakin MN, Pakhale S. Ethics of Health Research Supported by For-Profit Cannabis Companies: What Have We Learned from Big Tobacco?. Ann Am Thorac Soc. 2019 Mar;16(3):396-397. PubMed PMID: 30712358
  • Kiser TH, Reynolds PM, Moss M, Burnham EL, Ho PM, Vandivier RW. Impact of Macrolide Antibiotics on Hospital Readmissions and Other Clinically Important Outcomes in Critically Ill Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Propensity Score-Matched Cohort Study. Pharmacotherapy. 2019 Mar;39(3):242-252. PubMed PMID: 30663791
  • Reynolds PM, Van Matre ET, Wright GC, McQueen RB, Burnham EL, Ho PJM, Moss M, Vandivier RW, Kiser TH. Evaluation of Prophylactic Heparin Dosage Strategies and Risk Factors for Venous Thromboembolism in the Critically Ill Patient. Pharmacotherapy. 2019 Mar;39(3):232-241. PubMed PMID: 30592541
  • Bailey KL, Wyatt TA, Katafiasz DM, Taylor KW, Heires AJ, Sisson JH, Romberger DJ, Burnham EL. Alcohol and cannabis use alter pulmonary innate immunity. Alcohol. 2019 Nov;80:131-138. PubMed PMID: 30419300
  • Gaydos J, McNally A, Burnham EL. The impact of alcohol use disorders on pulmonary immune cell inflammatory responses to Streptococcus pneumoniae. Alcohol. 2019 Nov;80:119-130. PubMed PMID: 30195043
  • Afshar M, Burnham EL, Joyce C, Gagnon R, Dunn R, Albright JM, Ramirez L, Repine JE, Netzer G, Kovacs EJ. Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Ann Surg. 2019 Dec;270(6):1186-1193. PubMed PMID: 29697443
  • Reynolds PM, Van Matre ET, Wright GC, McQueen RB, Burnham EL, Michael Ho P, Moss M, Vandivier RW, Kiser TH. Evaluation of prophylactic heparin dosage strategies and risk factors for venous thromboembolism in the critically ill patient. Pharmacotherapy. 2018 Dec 28. [Epub ahead of print] PubMed PMID: 30592541
  • Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. The authors reply. Crit Care Med. 2018 Dec;46(12):e1224-e1225. PubMed PMID: 30444823
  • Bailey KL, Wyatt TA, Katafiasz DM, Taylor KW, Heires AJ, Sisson JH, Romberger DJ, Burnham EL. Alcohol and Cannabis Use Alter Pulmonary Innate Immunity. Alcohol. 2018 Nov 9. [Epub ahead of print] PubMed PMID: 30419300
  • Van Matre ET, Reynolds PM, MacLaren R, Mueller SW, Wright GC, Moss M, Burnham EL, Ho PM, Vandivier RW, Kiser TH. Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer. J Thromb Haemost. 2018 Dec;16(12):2492-2500. PubMed PMID: 30347498
  • Gaydos J, McNally A, Burnham EL. The Impact of Alcohol Use Disorders on Pulmonary Immune Cell Inflammatory Responses to Streptococcus pneumoniae. Alcohol. 2018 Sep 5. [Epub ahead of print] PubMed PMID: 30195043
  • Afshar M, Burnham EL, Joyce C, Kovacs EJ, Lowery EM. Optimal Cut-Points for Phosphatidylethanol Vary by Clinical Setting: Response to Nguyen and Seth's (2018) Letter to the Editor. Alcohol Clin Exp Res. 2018 Oct;42(10):2064-2065. PubMed PMID: 30059162
  • Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism. Crit Care Med. 2018 Oct;46(10):1617-1625. PubMed PMID: 29979222
  • Breathett K, Liu WG, Allen LA, Daugherty SL, Blair IV, Jones J, Grunwald GK, Moss M, Kiser TH, Burnham E, Vandivier RW, Clark BJ, Lewis EF, Mazimba S, Battaglia C, Ho PM, Peterson PN. African Americans Are Less Likely to Receive Care by a Cardiologist During an Intensive Care Unit Admission for Heart Failure. JACC Heart Fail. 2018 May;6(5):413-420. PubMed PMID: 29724363
  • Afshar M, Burnham EL, Joyce C, Gagnon R, Dunn R, Albright JM, Ramirez L, Repine JE, Netzer G, Kovacs EJ. Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Ann Surg. 2018 Apr 24. [Epub ahead of print] PubMed PMID: 29697443
  • Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. The authors reply. Crit Care Med. 2018 Apr;46(4):e347-e348. PubMed PMID: 29538131
  • Sottile PD, Kiser TH, Burnham EL, Ho PM, Allen RR, Vandivier RW, Moss M. An Observational Study of the Efficacy of Cisatracurium Compared with Vecuronium in Patients with or at Risk for Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Apr 1;197(7):897-904. PubMed PMID: 29241014
  • Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol. 2018 May;105:78-86. PubMed PMID: 29080833
  • Samuelson DR, Burnham EL, Maffei VJ, Vandivier RW, Blanchard EE, Shellito JE, Luo M, Taylor CM, Welsh DA. The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L107-L117. PubMed PMID: 28860145
  • Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
  • Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol. 2017 Oct 26. [Epub ahead of print] PubMed PMID: 29080833
  • Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. Crit Care Med. 2017 Dec;45(12):2055-2060. PubMed PMID: 29019851
  • Sapkota M, Burnham EL, DeVasure JM, Sweeter JM, Hunter CD, Duryee MJ, Klassen LW, Kharbanda KK, Sisson JH, Thiele GM, Wyatt TA. Malondialdehyde-Acetaldehyde (MAA) Protein Adducts Are Found Exclusively in the Lungs of Smokers with Alcohol Use Disorders and Are Associated with Systemic Anti-MAA Antibodies. Alcohol Clin Exp Res. 2017 Dec;41(12):2093-2099. PubMed PMID: 28941289
  • Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657
  • Afshar M, Netzer G, Mosier MJ, Cooper RS, Adams W, Burnham EL, Kovacs EJ, Durazo-Arvizu R, Kliethermes S. The Contributing Risk of Tobacco Use for ARDS Development in Burn-Injured Adults With Inhalation Injury. Respir Care. 2017 Nov;62(11):1456-1465. PubMed PMID: 28900039
  • Samuelson DR, Burnham EL, Maffei VJ, Vandivier RW, Blanchard EE, Shellito JE, Luo M, Taylor CM, Welsh DA. The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 31;:ajplung.00277.2017. [Epub ahead of print] PubMed PMID: 28860145
  • Fini MA, Gaydos J, McNally A, Karoor V, Burnham EL. Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1047-L1057. PubMed PMID: 28839105
  • Nedumaran B, Rudra P, Gaydos J, Kumar S, Meacham RB, Burnham EL, Malykhina AP. Impact of Regular Cannabis Use on Biomarkers of Lower Urinary Tract Function. Urology. 2017 Nov;109:223.e9-223.e16. PubMed PMID: 28827195
  • Afshar M, Burnham EL, Joyce C, Clark BJ, Yong M, Gaydos J, Cooper RS, Smith GS, Kovacs EJ, Lowery EM. Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients. Alcohol Clin Exp Res. 2017 Oct;41(10):1745-1753. PubMed PMID: 28792620
  • Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S. Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L930-L939. PubMed PMID: 28775099
  • Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M. The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study. Ann Am Thorac Soc. 2017 Jul;14(7):1154-1161. PubMed PMID: 28406727
  • Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS. Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med. 2017 Aug 15;196(4):425-429. PubMed PMID: 28240961
  • Abdul-Muneer PM, Alikunju S, Mishra V, Schuetz H, Szlachetka AM, Burnham EL, Haorah J. Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. Brain Behav Immun. 2017 May;62:291-305. PubMed PMID: 28232172
  • Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
  • Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 Feb 2. [Epub ahead of print] PubMed PMID: 26839359
  • Gaydos J, McNally A, Guo R, Vandivier RW, Simonian PL, Burnham EL. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 8;:ajplung.00242.2015. [Epub ahead of print] PubMed PMID: 26747782
  • Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb;99(2):373-86. PubMed PMID: 26428678
  • Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL, Brown LA. Alcohol and lung injury and immunity. Alcohol. 2016 Sep;55:51-59. PubMed PMID: 27788778
  • Burnham EL, McNally A, Gaydos J, Brown LA. The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking. Alcohol Clin Exp Res. 2016 Oct;40(10):2147-2160. PubMed PMID: 27627733
  • Nick JA, Caceres SM, Kret JE, Poch KR, Strand M, Faino AV, Nichols DP, Saavedra MT, Taylor-Cousar JL, Geraci MW, Burnham EL, Fessler MB, Suratt BT, Abraham E, Moss M, Malcolm KC. Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome. PLoS One. 2016 Sep 8;11(9):e0162490. PubMed PMID: 27606687
  • Cannon AR, Morris NL, Hammer AM, Curtis B, Remick DG, Yeligar SM, Poole L, Burnham EL, Wyatt TA, Molina PE, So-Armah K, Cisneros T, Wang G, Lang CH, Mandrekar P, Kovacs EJ, Choudhry MA. Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2016 Aug;54:73-7. PubMed PMID: 27522326
  • Burnham EL, Roman J. Composition of the Sepsis Definitions Task Force. JAMA. 2016 Jul 26;316(4):460-1. PubMed PMID: 27458965
  • Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 Feb 2. [Epub ahead of print] PubMed PMID: 26839359
  • Afshar M, Foster CL, Layden JE, Burnham EL. Azithromycin use and outcomes in severe sepsis patients with and without pneumonia. J Crit Care. 2016 Apr;32:120-5. PubMed PMID: 26803186
  • O'Halloran EB, Curtis BJ, Afshar M, Chen MM, Kovacs EJ, Burnham EL. Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. Alcohol. 2016 Feb;50:43-50. PubMed PMID: 26781212
  • Gaydos J, McNally A, Guo R, Vandivier RW, Simonian PL, Burnham EL. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L507-18. PubMed PMID: 26747782
  • Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb;99(2):373-86. PubMed PMID: 26428678
  • Afshar M, Foster CL, Layden JE, Burnham EL. Azithromycin use and outcomes in severe sepsis patients with and without pneumonia. J Crit Care. 2015 Dec 21. [Epub ahead of print] PubMed PMID: 26803186
  • O'Halloran EB, Curtis BJ, Afshar M, Chen MM, Kovacs EJ, Burnham EL. Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. Alcohol. 2015 Nov 24. [Epub ahead of print] PubMed PMID: 26781212
  • Bailey KL, Romberger DJ, Katafiasz DM, Heires AJ, Sisson JH, Wyatt TA, Burnham EL. TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. Alcohol Clin Exp Res. 2015 Sep;39(9):1691-7. PubMed PMID: 26208141
  • Obianyo O, Liang Y, Burnham EL, Mehta A, Park Y, Uppal K, Harris FL, Jones DP, Brown LA. Metabolic Consequences of Chronic Alcohol Abuse in Non-Smokers: A Pilot Study. PLoS One. 2015;10(6):e0129570. PubMed PMID: 26102199
  • Biehl JR, Burnham EL. Cannabis Smoking in 2015: A Concern for Lung Health?. Chest. 2015 Sep;148(3):596-606. PubMed PMID: 25996274
  • Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S1-2. PubMed PMID: 25830827
  • Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine Signaling via the Serotonin Transporter Regulates Clearance of Apoptotic Cells. J Biol Chem. 2014 Feb 25. [Epub ahead of print] PubMed PMID: 24570000
  • Burnham EL. 24/7 attendings: "helicoptering" the housestaff?. Pediatrics. 2014 Jan;133(1):131-3. PubMed PMID: 24323999
  • Burnham EL, Hyzy RC, Paine R 3rd, Kelly AM, Quint LE, Lynch D, Curran-Everett D, Moss M, Standiford TJ. Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS. Chest. 2014 Nov;146(5):1196-204. PubMed PMID: 24722949
  • Pfund C, House SC, Asquith P, Fleming MF, Buhr KA, Burnham EL, Eichenberger Gilmore JM, Huskins WC, McGee R, Schurr K, Shapiro ED, Spencer KC, Sorkness CA. Training mentors of clinical and translational research scholars: a randomized controlled trial. Acad Med. 2014 May;89(5):774-82. PubMed PMID: 24667509
  • Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014 Apr 11;289(15):10466-75. PubMed PMID: 24570000
  • Burnham EL. 24/7 attendings: "helicoptering" the housestaff?. Pediatrics. 2014 Jan;133(1):131-3. PubMed PMID: 24323999
  • Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan;43(1):276-85. PubMed PMID: 23520315
  • Smart A, Thompson BT, Needham DM, Hopkins RO, Williams A, Burnham EL, Moss M, NHLBI ARDS Network Investigators. Surrogate consent for genetic testing, the reconsent process, and consent for long-term outcomes in acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2013 Dec 1;188(11):1370-3. PubMed PMID: 24289781
  • Macht M, King CJ, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Post-extubation dysphagia is associated with longer hospitalization in survivors of critical illness with neurologic impairment. Crit Care. 2013 Jun 20;17(3):R119. [Epub ahead of print] PubMed PMID: 23786755
  • Clark BJ, Bull TM, Benson AB, Stream AR, Macht M, Gaydos J, Meadows C, Burnham EL, Moss M, the ARDS Network Investigators. Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study. Crit Care. 2013 May 24;17(3):R92. [Epub ahead of print] PubMed PMID: 23706007
  • Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep;37(9):1536-43. PubMed PMID: 23647435
  • Burnham EL, Kovacs EJ, Davis CS. Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L873-82. PubMed PMID: 23605000
  • Clark BJ, Williams A, Feemster LM, Bradley KA, Macht M, Moss M, Burnham EL. Alcohol screening scores and 90-day outcomes in patients with acute lung injury. Crit Care Med. 2013 Jun;41(6):1518-25. PubMed PMID: 23538449
  • Burnham EL, Hyzy RC, Paine R 3rd, Coley C 2nd, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med. 2013 Feb;41(2):445-56. PubMed PMID: 23263616
  • Finigan JH, Mishra R, Vasu VT, Silveira LJ, Nethery DE, Standiford TJ, Burnham EL, Moss M, Kern JA. Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J. 2013 Feb;41(2):396-401. PubMed PMID: 22599357
  • Fleming M, Burnham EL, Huskins WC. Mentoring translational science investigators. JAMA. 2012 Nov 21;308(19):1981-2. PubMed PMID: 23168821
  • Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res. 2012 Mar;36(3):544-51. PubMed PMID: 21950704
  • Baker TA, Davis CS, Bach HH 4th, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin and stromal cell-derived factor-1a in bronchoalveolar lavage fluid after burn and inhalation injury. J Burn Care Res. 2012 Jan-Feb;33(1):57-64. PubMed PMID: 22105097
  • Paine R 3rd, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med. 2012 Jan;40(1):90-7. PubMed PMID: 21926600
  • Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Diagnosis and treatment of post-extubation dysphagia: results from a national survey. J Crit Care. 2012 Dec;27(6):578-86. PubMed PMID: 23084136
  • Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest. 2012 Dec;142(6):1569-1576. PubMed PMID: 22797508
  • Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L688-99. PubMed PMID: 22268125
  • Albright JM, Davis CS, Bird MD, Ramirez L, Kim H, Burnham EL, Gamelli RL, Kovacs EJ. The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med. 2012 Apr;40(4):1113-21. PubMed PMID: 22067627
  • Fisichella PM, Davis CS, Lundberg PW, Lowery E, Burnham EL, Alex CG, Ramirez L, Pelletiere K, Love RB, Kuo PC, Kovacs EJ. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery. 2011 Oct;150(4):598-606. PubMed PMID: 22000170
  • Burnham EL, Schiro S, Fleming M. Mentoring K scholars: strategies to support research mentors. Clin Transl Sci. 2011 Jun;4(3):199-203. PubMed PMID: 21707951
  • Majka S, Burnham E, Stenmark KR. Cell-based therapies in pulmonary hypertension: who, what, and when?. Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L9-L11. PubMed PMID: 21515661
  • Burnham EL, Phang TL, House R, Vandivier RW, Moss M, Gaydos J. Alveolar macrophage gene expression is altered in the setting of alcohol use disorders. Alcohol Clin Exp Res. 2011 Feb;35(2):284-94. PubMed PMID: 21121937
  • Burnham EL, Fleming M. Selection of research mentors for K-funded scholars. Clin Transl Sci. 2011 Apr;4(2):87-92. PubMed PMID: 21463493
  • Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit Care. 2011;15(5):R231. PubMed PMID: 21958475
  • Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011;6(7):e21958. PubMed PMID: 21755013
  • Burnham EL, Gaydos J, Hess E, House R, Cooper J. Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage. Alcohol Alcohol. 2010 Sep-Oct;45(5):414-21. PubMed PMID: 20729531
  • Burnham EL, Mealer M, Gaydos J, Majka S, Moss M. Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Am J Respir Cell Mol Biol. 2010 Sep;43(3):326-33. PubMed PMID: 19843706
  • Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct;34(10):1723-32. PubMed PMID: 20608904
  • Burnham EL, Moss M, Geraci MW. The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med. 2010 Jun 1;181(11):1159-60. PubMed PMID: 20516489
  • Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol. 2009 Nov;86(5):1097-104. PubMed PMID: 19602670
  • Burnham EL, Halkar R, Burks M, Moss M. The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans. Alcohol Alcohol. 2009 Jan-Feb;44(1):8-12. PubMed PMID: 18567916
  • Mealer M, Burnham EL, Goode CJ, Rothbaum B, Moss M. The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses. Depress Anxiety. 2009;26(12):1118-26. PubMed PMID: 19918928
  • de Wit M, Gennings C, Zilberberg M, Burnham EL, Moss M, Balster RL. Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients. Addiction. 2008 Sep;103(9):1500-8. PubMed PMID: 18636996
  • Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov;134(5):1074-1079. PubMed PMID: 18988783
  • Burnham EL. Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome?. Anesthesiology. 2008 Mar;108(3):354-6. PubMed PMID: 18292671
  • Yeh MY, Burnham EL, Moss M, Brown LA. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med. 2008 Feb;102(2):248-55. PubMed PMID: 17977706
  • Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1028-39. PubMed PMID: 18931051
  • Burnham EL. Identification of risky alcohol consumption in the preoperative assessment: opportunity to diagnose and intervene. Anesthesiology. 2008 Aug;109(2):169-70. PubMed PMID: 18648224
  • Martin J, Helm K, Ruegg P, Varella-Garcia M, Burnham E, Majka S. Adult lung side population cells have mesenchymal stem cell potential. Cytotherapy. 2008;10(2):140-51. PubMed PMID: 18368593
  • de Wit M, Best AM, Gennings C, Burnham EL, Moss M. Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res. 2007 Jul;31(7):1224-30. PubMed PMID: 17511746
  • Yeh MY, Burnham EL, Moss M, Brown LA. Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med. 2007 Aug 1;176(3):270-6. PubMed PMID: 17507544
  • Burnham EL, Moss M, Ritzenthaler JD, Roman J. Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Alcohol Clin Exp Res. 2007 Apr;31(4):675-83. PubMed PMID: 17374047
  • Khan J, Burnham EL, Moss M. Acquired weakness in the ICU: critical illness myopathy and polyneuropathy. Minerva Anestesiol. 2006 Jun;72(6):401-6. PubMed PMID: 16682908
  • Esper A, Burnham EL, Moss M. The effect of alcohol abuse on ARDS and multiple organ dysfunction. Minerva Anestesiol. 2006 Jun;72(6):375-81. PubMed PMID: 16682904
  • Burnham E, Moss M. Progenitor cells in acute lung injury. Minerva Anestesiol. 2006 Jun;72(6):369-74. PubMed PMID: 16682903
  • Moss M, Burnham EL. Alcohol abuse in the critically ill patient. Lancet. 2006 Dec 23;368(9554):2231-42. PubMed PMID: 17189035
  • Burnham EL, Moss M, Ziegler TR. Myopathies in critical illness: characterization and nutritional aspects. J Nutr. 2005 Jul;135(7):1818S-1823S. PubMed PMID: 15987872
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Professional Memberships

  • American Thoracic Society, Member, Critical Care Assembly
  • American Board of Internal Medicine, Pulmonary Exam Writing Committee
  • Research Society on Alcoholism, Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pulmonary Disease, Board Certification (2011)
  • Critical Care Medicine, Board Certification (2012)
Conditions & Treatments
  • Critical Care
  • Lungs and Breathing - Pulmonary Disorders
  • Lungs and Breathing
Clinical Interests
Critical Care Delivery, Acute Respiratory Distress Syndrome, Acute Lung Injury, Alcohol and Substance Use Disorders

Personal Interests
Time with family, skiing, cooking, gardening

Public Speaking
Yes
I have spoken to the public regarding the impact of substance use and abuse on lung health, including the impact of alcohol, cannabis, and vaping-related products.

General Information

Medical Schools:
  • MD, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School (1995)
Graduate Schools:
  • MSc, Emory University Rollins School of Public Health (2008)
Undergraduate Schools:
  • BS, Texas Christian University (TX) (1991)
Internships:
  • University of Texas Southwestern Medical School Program (1996)
Residency Programs:
  • University of Texas Southwestern Medical School Program, Internal Medicine (1998)
Fellowships:
  • Emory University School of Medicine Program, Pulmonary Disease and Critical Care Medicine (2002)
Languages: English
Department: Medicine-Pulmonary Sciences & Critical Care
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