Margaret E. Wierman, MD
Professor, Medicine-Endocrinology/Metabolism/Diabetes

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Medical School:
  • MD, Baylor College of Medicine (1979)
Undergraduate School:
  • BA, Bryn Mawr College (PA) (1975)
Internship:
  • Baylor College of Medicine Program (1980)
Residency:
  • Baylor College of Medicine Program, Chief Resident, Internal Medicine (1983)
Fellowships:
  • Massachusetts General Hospital/Brigham and Women's Hospital Program, Endocrinology, Diabetes and Metabolism (1987)
Languages: English
Department: Medicine-Endocrinology/Metabolism/Diabetes

Professional Titles

  • Professor, Medicine-Endocrinology/Metabolism/Diabetes
  • Director Pituitary Program UCD, Chief of Endocrinology, Denver VAMC

Research Interests

My research focuses on GnRH neuron development, survival migration & gene expression, Molecular pathogenesis of pituitary tumors and Neuroendocrine dysfunction after traumatic brain injury.

Publications

  • Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, Crooks B, Dvir R, Farah R, Hijiya N, George B, Laetsch TW, Larouche V, Lindhorst S, Luiten RC, Magimairajan V, Mason G, Mason W, Mordechai O, Mushtaq N, Nicholas G, Oren M, Palma L, Pedroza LA, Ramdas J, Samuel D, Wolfe Schneider K, Seeley A, Semotiuk K, Shamvil A, Sumerauer D, Toledano H, Tomboc P, Wierman M, Van Damme A, Lee YY, Zapotocky M, Bouffet E, Durno C, Aronson M, Gallinger S, Foulkes WD, Malkin D, Tabori U, Pearson CE. Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. J Clin Oncol. 2019 Jan 4;:JCO1800474. [Epub ahead of print] PubMed PMID: 30608896
  • Grossmann M, Wierman ME, Angus P, Handelsman DJ. Reproductive Endocrinology of Non-Alcoholic Fatty Liver Disease. Endocr Rev. 2018 Nov 30. [Epub ahead of print] PubMed PMID: 30500887
  • Deaver KE, Catel CP, Lillehei KO, Wierman ME, Kerr JM. Strategies to reduce readmissions for hyponatremia after transsphenoidal surgery for pituitary adenomas. Endocrine. 2018 Nov;62(2):333-339. PubMed PMID: 29961198
  • Kiseljak-Vassiliades K, Zhang Y, Kar A, Razzaghi R, Xu M, Gowan K, Raeburn CD, Albuja-Cruz M, Jones KL, Somerset H, Fishbein L, Leong S, Wierman ME. Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma. Endocrinology. 2018 Jul 1;159(7):2532-2544. PubMed PMID: 29790920
  • Kiseljak-Vassiliades K, Zhang Y, Bagby S, Kar A, Pozdeyev N, Xu M, Gowan K, Sharma V, Raeburn CD, Albuja-Cruz M, Jones KL, Fishbein L, Schweppe R, Somerset HL, Pitts TM, Leong S, Wierman M. Development of new preclinical models to advance adrenocortical carcinoma research. Endocr Relat Cancer. 2018 Jan 25. [Epub ahead of print] PubMed PMID: 29371329
  • Melanson EL, Lyden K, Gibbons E, Gavin KM, Wolfe P, Wierman ME, Schwartz RS, Kohrt WM. Influence of Estradiol Status on Physical Activity in Premenopausal Women. Med Sci Sports Exerc. 2018 Aug;50(8):1704-1709. PubMed PMID: 29509642
  • Gavin KM, Shea KL, Gibbons E, Wolfe P, Schwartz RS, Wierman ME, Kohrt WM. Gonadotropin-releasing hormone agonist in premenopausal women does not alter hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone. Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E316-E325. PubMed PMID: 29631362
  • Roof AK, Jirawatnotai S, Trudeau T, Kuzyk C, Wierman ME, Kiyokawa H, Gutierrez-Hartmann A. The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine. Endocrinology. 2018 Jun 1;159(6):2421-2434. PubMed PMID: 29726995
  • Carr SB, Kleinschmidt-DeMasters BK, Kerr JM, Kiseljak-Vassiliades K, Wierman ME, Lillehei KO. Negative surgical exploration in patients with Cushing's disease: benefit of two-thirds gland resection on remission rate and a review of the literature. J Neurosurg. 2017 Dec 8;:1-8. [Epub ahead of print] PubMed PMID: 29219752
  • Kiseljak-Vassiliades K, Zhang Y, Bagby S, Kar A, Pozdeyev N, Xu M, Gowan K, Sharma V, Raeburn CD, Albuja-Cruz M, Jones KL, Fishbein L, Schweppe R, Somerset HL, Pitts TM, Leong S, Wierman M. Development of new preclinical models to advance adrenocortical carcinoma research. Endocr Relat Cancer. 2018 Jan 25. [Epub ahead of print] PubMed PMID: 29371329
  • Kiseljak-Vassiliades K, Mills TS, Zhang Y, Xu M, Lillehei KO, Kleinschmidt-DeMasters BK, Wierman ME. Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 (PERP) in Growth Hormone Tumors. Endocrinology. 2017 Feb 9. [Epub ahead of print] PubMed PMID: 28323918
  • Carr SB, Kleinschmidt-DeMasters BK, Kerr JM, Kiseljak-Vassiliades K, Wierman ME, Lillehei KO. Negative surgical exploration in patients with Cushing's disease: benefit of two-thirds gland resection on remission rate and a review of the literature. J Neurosurg. 2017 Dec 8;:1-8. [Epub ahead of print] PubMed PMID: 29219752
  • Kohrt WM, Wierman ME. Preventing Fat Gain by Blocking Follicle-Stimulating Hormone. N Engl J Med. 2017 Jul 20;377(3):293-295. PubMed PMID: 28723332
  • Kiseljak-Vassiliades K, Mills TS, Zhang Y, Xu M, Lillehei KO, Kleinschmidt-DeMasters BK, Wierman ME. Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 (PERP) in Growth Hormone Tumors. Endocrinology. 2017 Feb 9. [Epub ahead of print] PubMed PMID: 28323918
  • Xiong W, Matheson CJ, Xu M, Backos DS, Mills TS, Salian-Mehta S, Kiseljak-Vassiliades K, Reigan P, Wierman ME. Structure-based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. Mol Cancer Ther. 2015 Dec 31. [Epub ahead of print] PubMed PMID: 26721946
  • Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL. Changing of the Guard. Endocr Rev. 2016 Feb;2016(1):1-2. PubMed PMID: 27454359
  • Xiong W, Matheson CJ, Xu M, Backos DS, Mills TS, Salian-Mehta S, Kiseljak-Vassiliades K, Reigan P, Wierman ME. Structure-based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. Mol Cancer Ther. 2015 Dec 31. [Epub ahead of print] PubMed PMID: 26721946
  • Kiseljak-Vassiliades K, Xu M, Mills TS, Smith EE, Silveira LJ, Lillehei KO, Kerr JM, Kleinschmidt-DeMasters BK, Wierman ME. Differential somatostatin receptor (SSTR) 1-5 expression and downstream effectors in histologic subtypes of growth hormone pituitary tumors. Mol Cell Endocrinol. 2015 Dec 5;417:73-83. PubMed PMID: 26391562
  • Melanson EL, Gavin KM, Shea KL, Wolfe P, Wierman ME, Schwartz RS, Kohrt WM. Regulation of energy expenditure by estradiol in premenopausal women. J Appl Physiol (1985). 2015 Nov 1;119(9):975-81. PubMed PMID: 26338457
  • Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL. Changing of the Guard. Endocr Rev. 2015 Aug;36(4):345-6. PubMed PMID: 26240982
  • Wierman ME. Risks of Different Testosterone Preparations: Too Much, Too Little, Just Right. JAMA Intern Med. 2015 Jul;175(7):1197-8. PubMed PMID: 25961437
  • Salian-Mehta S, Xu M, McKinsey TA, Tobet S, Wierman ME. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. J Biol Chem. 2015 May 29;290(22):14045-56. PubMed PMID: 25873389
  • Shea KL, Gavin KM, Melanson EL, Gibbons E, Stavros A, Wolfe P, Kittelson JM, Vondracek SF, Schwartz RS, Wierman ME, Kohrt WM. Body composition and bone mineral density after ovarian hormone suppression with or without estradiol treatment. Menopause. 2015 Oct;22(10):1045-52. PubMed PMID: 25783468
  • Wierman MB, Matecic M, Valsakumar V, Li M, Smith DL Jr, Bekiranov S, Smith JS. Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations. Aging (Albany NY). 2015 Mar;7(3):177-94. PubMed PMID: 25769345
  • Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015 Mar;29(3):460-72. PubMed PMID: 25650755
  • Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ. Statement of principle. Horm Cancer. 2015 Feb;6(1):1. PubMed PMID: 25410830
  • Kiseljak-Vassiliades K, Carlson NE, Borges MT, Kleinschmidt-DeMasters BK, Lillehei KO, Kerr JM, Wierman ME. Growth hormone tumor histological subtypes predict response to surgical and medical therapy. Endocrine. 2014 Aug 17. [Epub ahead of print] PubMed PMID: 25129651
  • Ho PM, Barón AE, Wierman ME. Deaths and cardiovascular events in men receiving testosterone--reply. JAMA. 2014 Mar 5;311(9):964-5. PubMed PMID: 24595788
  • Salian-Mehta S, Xu M, Knox A, Plummer L, Slavov D, Taylor M, Bevers S, Hodges R, Crowley W Jr, Wierman M. Functional Consequences of AXL Sequence Variants in Idiopathic Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab. 2014 Jan 29;:jc20133426. [Epub ahead of print] PubMed PMID: 24476074
  • Vigen R, O'Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Woning G, Wierman ME, Plomondon ME, Rumsfeld JS, Ho PM. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013 Nov 6;310(17):1829-36. PubMed PMID: 24193080
  • Salian-Mehta S, Xu M, Wierman ME. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. Mol Cell Endocrinol. 2013 Jul 15;374(1-2):92-100. PubMed PMID: 23648337
  • Weickhardt AJ, Doebele RC, Purcell WT, Bunn PA, Oton AB, Rothman MS, Wierman ME, Mok T, Popat S, Bauman J, Nieva J, Novello S, Ou SH, Camidge DR. Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer. 2013 Jul 1;119(13):2383-90. PubMed PMID: 23585220
  • Rosner W, Hankinson SE, Sluss PM, Vesper HW, Wierman ME. Challenges to the measurement of estradiol: an endocrine society position statement. J Clin Endocrinol Metab. 2013 Apr;98(4):1376-87. PubMed PMID: 23463657
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Practice Locations

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Denver Veterans Affairs Medical Center
1055 Clermont St
Denver, CO 80220
1-888-336-8262

Endocrinology/Diabetes/Metabolism - Anschutz
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2650

Hospital Affiliation
  • University of Colorado Hospital
  • Veterans Affairs Medical Center
Center Affiliations

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1982)
  • Endocrinology, Diabetes and Metabolism, Board Certification (1985)
Conditions & Treatments
  • Brain and Nervous System - Pituitary Disorders
  • Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
  • Endocrine System (Hormones) - Thyroid Disease
  • Endocrine System (Hormones) - Adrenal Diseases
  • Men's Health - Infertility and Reproductive Medicine
  • Women's Health - Contraception
  • Women's Health - Hormone Replacement Therapy
  • Women's Health - Menopause
  • Endocrine System (Hormones)
  • Brain and Nervous System
  • Men's Health
  • Women's Health
Clinical Interests
I am interested in Reproductive Endocrinology, Neuroendocrinology, Pituitary Disease, Disorders of Adolescence and Menopause and Hypogonadism in Men and Women.

General Information

Medical Schools:
  • MD, Baylor College of Medicine (1979)
Undergraduate Schools:
  • BA, Bryn Mawr College (PA) (1975)
Internships:
  • Baylor College of Medicine Program (1980)
Residency Programs:
  • Baylor College of Medicine Program, Chief Resident, Internal Medicine (1983)
Fellowships:
  • Massachusetts General Hospital/Brigham and Women's Hospital Program, Endocrinology, Diabetes and Metabolism (1987)
Download CV
Languages: English
Department: Medicine-Endocrinology/Metabolism/Diabetes
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