Timothy Benke, MD, PhD
Associate Professor, Pediatrics-Neurology

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Medical School:
  • MD, Baylor College of Medicine (1995)
Graduate Schools :
  • MS, Rice University (1989)
  • PhD, Baylor College Of Medicine (1994)
Undergraduate School:
  • BS, Vanderbilt University (TN) (1986)
Internship:
  • Baylor College of Medicine Program (1997)
Residency:
  • Baylor College of Medicine Program, Pediatrics (1998)
Fellowships:
  • Baylor College of Medicine Program, Child Neurology (2001)
Languages: English
Department: Pediatrics-Neurology

Professional Titles

  • Associate Professor, Pediatrics-Neurology
  • Director of Research-Neurosciences Institute
  • The Ponzio Family Chair in Pediatric Neurology Research
Research interests for Patients:
Function of synapses; synaptic changes associated with learning, memory and development; seizures. Rett Syndrome. CDKL5 disorder. GRIN disorders. Neurogenetic conditions.

Publications

  • Neul JL, Benke TA, Marsh ED, Skinner SA, Merritt J, Lieberman DN, Standridge S, Feyma T, Heydemann P, Peters S, Ryther R, Jones M, Suter B, Kaufmann WE, Glaze DG, Percy AK. The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2. Am J Med Genet B Neuropsychiatr Genet. 2019 Jan;180(1):55-67. PubMed PMID: 30536762
  • Benke T, Traynelis SF. AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise. Neurochem Res. 2018 Feb 23. [Epub ahead of print] PubMed PMID: 29476449
  • Kirk ME, Meredith FL, Benke TA, Rennie KJ. AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents. J Neurophysiol. 2017 Jun 1;117(6):2312-2323. PubMed PMID: 28298303
  • Larson A, Weisfeld-Adams JD, Benke TA, Bonnen PE. Cerebrotendinous Xanthomatosis Presenting with Infantile Spasms and Intellectual Disability. JIMD Rep. 2016 Nov 18. [Epub ahead of print] PubMed PMID: 27858369
  • Larson A, Weisfeld-Adams JD, Benke TA, Bonnen PE. Cerebrotendinous Xanthomatosis Presenting with Infantile Spasms and Intellectual Disability. JIMD Rep. 2016 Nov 18. [Epub ahead of print] PubMed PMID: 27858369
  • Goodell DJ, Benke TA, Bayer KU. Developmental restoration of LTP deficits in heterozygous CaMKIIa KO mice. J Neurophysiol. 2016 Nov 1;116(5):2140-2151. PubMed PMID: 27535377
  • Goldman AM, LaFrance WC Jr, Benke T, Asato M, Drane D, Pack A, Syed T, Doss R, Lhatoo S, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across The Lifespan. Epilepsy Curr. 2016 May-Jun;16(3):198-205. PubMed PMID: 27330453
  • Barcomb K, Hell JW, Benke TA, Bayer KU. The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength. J Biol Chem. 2016 Jul 29;291(31):16082-9. PubMed PMID: 27246855
  • O'Leary H, Bernard PB, Castano AM, Benke TA. Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure. Neurobiol Dis. 2015 Dec 16. [Epub ahead of print] PubMed PMID: 26706598
  • Bernard PB, Benke TA. Early life seizures: Evidence for chronic deficits linked to autism and intellectual disability across species and models. Exp Neurol. 2015 Jan;263:72-8. PubMed PMID: 25284323
  • Benke TA. What you seize is what you get: do we yet understand epilepsy in rett syndrome?. Epilepsy Curr. 2014 Sep;14(5):283-5. PubMed PMID: 25346641
  • Benke T. What the dentate gyrus and the millennial in your basement have in common. Epilepsy Curr. 2014 May;14(3):152-4. PubMed PMID: 24940163
  • Benke T. Benchmark IV Progressing Nicely: Rational Pharmacotherapy May Address Cognitive Decline in Epilepsy. Epilepsy Curr. 2014 Mar;14(2):90-2. PubMed PMID: 24872788
  • Barcomb K, Buard I, Coultrap SJ, Kulbe JR, O'Leary H, Benke TA, Bayer KU. Autonomous CaMKII requires further stimulation by Ca2 /calmodulin for enhancing synaptic strength. FASEB J. 2014 Aug;28(8):3810-9. PubMed PMID: 24843070
  • Bernard PB, Castano AM, Bayer KU, Benke TA. Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures. Neuropharmacology. 2014 Sep;84:1-12. PubMed PMID: 24780380
  • Bernard PB, Castano AM, O'Leary H, Simpson K, Browning MD, Benke TA. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013 Nov;59:1-17. PubMed PMID: 23831253
  • Benke T. O brother, wherefore are thou? Calcium-permeable AMPA receptors make an appearance in adult status epilepticus. Epilepsy Curr. 2013 Jan;13(1):32-4. PubMed PMID: 23447737
  • Thyssen A, Mitchell M, Qvarnstrom Y, Rao S, Benke TA, Glodé MP. Eosinophilic meningitis in a previously healthy 13-year-old child. Pediatr Infect Dis J. 2013 Feb;32(2):194, 198. PubMed PMID: 23328824
  • Meredith FL, Benke TA, Rennie KJ. Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events. J Assoc Res Otolaryngol. 2012 Dec;13(6):745-58. PubMed PMID: 22825486
  • Boada R, Hutaff-Lee C, Schrader A, Weitzenkamp D, Benke TA, Goldson EJ, Costa AC. Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial. Transl Psychiatry. 2012 Jul 17;2:e141. PubMed PMID: 22806212
  • Liu X, Li F, Stubblefield EA, Blanchard B, Richards TL, Larson GA, He Y, Huang Q, Tan AC, Zhang D, Benke TA, Sladek JR, Zahniser NR, Li CY. Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Cell Res. 2012 Feb;22(2):321-32. PubMed PMID: 22105488
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Professional Memberships

  • American Epilepsy Society, Member
  • Society for Neuroscience, Member
  • Child Neurology Society, Member
  • Neuorpharmacology (Journal), Editorial Board

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Child Neurology, Board Certification (2002)
Conditions & Treatments
  • Brain and Nervous System
  • Brain and Nervous System - Cerebral Palsy
  • Brain and Nervous System - Chiari Malformation
  • Brain and Nervous System - Epilepsy
  • Brain and Nervous System - Meningitis
  • Brain and Nervous System - Migraine
  • Brain and Nervous System - Movement Disorders
  • Brain and Nervous System - Neuromuscular Diseases
  • Brain and Nervous System - Neurovascular Conditions
  • Brain and Nervous System - Traumatic and Acquired Brain Injuries
  • Brain and Nervous System - Stroke
  • Genetic Conditions and Testing
Clinical Interest for Patients
General Pediatric Neurology. Rett Syndrome. CDKL5 disorder. GRIN disorders. Neurogenetic conditions.

General Information

Medical Schools:
  • MD, Baylor College of Medicine (1995)
Graduate Schools:
  • MS, Rice University (1989)
  • PhD, Baylor College Of Medicine (1994)
Undergraduate Schools:
  • BS, Vanderbilt University (TN) (1986)
Internships:
  • Baylor College of Medicine Program (1997)
Residency Programs:
  • Baylor College of Medicine Program, Pediatrics (1998)
Fellowships:
  • Baylor College of Medicine Program, Child Neurology (2001)
Languages: English
Department: Pediatrics-Neurology
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