James Degregori, PhD

Thomas F, DeGregori J, Marusyk A, Dujon AM, Ujvari B, Capp JP, Gatenby R, Nedelcu AM. A new perspective on tumor progression: Evolution via selection for function. Evol Med Public Health. 2024;12(1):172-177. PubMed PMID: 39364294

Giraudeau M, Vincze O, Dupont SM, Sepp T, Baines C, Lemaitre JF, Lemberger K, Gentès S, Boddy A, Dujon AM, Bramwell G, Harris V, Ujvari B, Alix-Panabières C, Lair S, Sayag D, Conde DA, Colchero F, Harrison TM, Pavard S, Padilla-Morales B, Chevallier D, Hamede R, Roche B, Malkocs T, Aktipis AC, Maley C, DeGregori J, Le Loc'h G, Thomas F. Approaches and methods to study wildlife cancer. J Anim Ecol. 2024 Oct;93(10):1410-1428. PubMed PMID: 39189422

Schleicher WE, Hoag B, De Dominici M, DeGregori J, Pietras EM. CHIP: a clonal odyssey of the bone marrow niche. J Clin Invest. 2024 Aug 1;134(15). PubMed PMID: 39087468

Bramwell G, DeGregori J, Thomas F, Ujvari B. Transmissible cancers, the genomes that do not melt down. Evolution. 2024 Jul 1;78(7):1205-1211. PubMed PMID: 38656785

Chia SB, Johnson BJ, Hu J, Vermeulen R, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, Pereira FV, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Papanicolaou M, Beheshti A, Baylin SB, Costello J, Bartley JM, Morrison TE, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs. Res Sq. 2024 Apr 5. PubMed PMID: 38645169

Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, Bar-Sagi D, Bernards R, Bullman S, DeGregori J, Elliott C, Erez A, Evan G, Febbraio MA, Hidalgo A, Jamal-Hanjani M, Joyce JA, Kaiser M, Lamia K, Locasale JW, Loi S, Malanchi I, Merad M, Musgrave K, Patel KJ, Quezada S, Wargo JA, Weeraratna A, White E, Winkler F, Wood JN, Vousden KH, Hanahan D. Embracing cancer complexity: Hallmarks of systemic disease. Cell. 2024 Mar 28;187(7):1589-1616. PubMed PMID: 38552609

Pham-Danis C, Chia SB, Scarborough HA, Danis E, Nemkov T, Kleczko EK, Navarro A, Goodspeed A, Bonney EA, Dinarello CA, Marchetti C, Nemenoff RA, Hansen K, DeGregori J. Inflammation promotes aging-associated oncogenesis in the lung. bioRxiv. 2024 Mar 5. PubMed PMID: 38496448

Giraudeau M, Vincze O, Dupont SM, Sepp T, Baines C, Lemaitre JF, Lemberger K, Gentès S, Boddy A, Dujon AM, Bramwell G, Harris V, Ujvari B, Alix-Panabières C, Lair S, Sayag D, Conde DA, Colchero F, Harrison TM, Pavard S, Padilla-Morales B, Chevallier D, Hamede R, Roche B, Malkocs T, Aktipis AC, Maley C, DeGregori J, Le Loc'h G, Thomas F. Approaches and methods to study wildlife cancer. J Anim Ecol. 2024 Oct;93(10):1410-1428. PubMed PMID: 39189422

Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, Bar-Sagi D, Bernards R, Bullman S, DeGregori J, Elliott C, Erez A, Evan G, Febbraio MA, Hidalgo A, Jamal-Hanjani M, Joyce JA, Kaiser M, Lamia K, Locasale JW, Loi S, Malanchi I, Merad M, Musgrave K, Patel KJ, Quezada S, Wargo JA, Weeraratna A, White E, Winkler F, Wood JN, Vousden KH, Hanahan D. Embracing cancer complexity: Hallmarks of systemic disease. Cell. 2024 Mar 28;187(7):1589-1616. PubMed PMID: 38552609

Bramwell G, DeGregori J, Thomas F, Ujvari B. Transmissible cancers, the genomes that do not melt down. Evolution. 2024 Jul 1;78(7):1205-1211. PubMed PMID: 38656785

Pham-Danis C, Chia SB, Scarborough HA, Danis E, Nemkov T, Zaberezhnyy V, …. J. DeGregori. Inflammation Promotes Aging-Associated Oncogenesis in the Lung. Aging and Cancer. 2024:e12077.

Assante A, Lkhagvadorj K, Clambey ET, Danhorn T, Merrick DT, Keith RL, New ML, Degregori J, Miller YE, Ghosh M. Reduced Progenitor Function and Altered Immune Landscape Contribute to Field Cancerization of Lung Adenocarcinoma. Am J Respir Crit Care Med. 2023 Oct 15;208(8):903-905. PubMed PMID: 37639330

De Dominici M, DeGregori J. Our ancestry dictates clonal architecture and skin cancer susceptibility. Nat Genet. 2023 Sep;55(9):1428-1429. PubMed PMID: 37537258

Capp JP, Thomas F, Marusyk A, M Dujon A, Tissot S, Gatenby R, Roche B, Ujvari B, DeGregori J, Brown JS, Nedelcu AM. The paradox of cooperation among selfish cancer cells. Evol Appl. 2023 Jul;16(7):1239-1256. PubMed PMID: 37492150

Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ Jr, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, van Maldegem F, Boumelha J, Veeriah S, Rowan A, Naceur-Lombardelli C, Karasaki T, Sivakumar M, De S, Caswell DR, Nagano A, Black JRM, Martínez-Ruiz C, Ryu MH, Huff RD, Li S, Favé MJ, Magness A, Suárez-Bonnet A, Priestnall SL, Lüchtenborg M, Lavelle K, Pethick J, Hardy S, McRonald FE, Lin MH, Troccoli CI, Ghosh M, Miller YE, Merrick DT, Keith RL, Al Bakir M, Bailey C, Hill MS, Saal LH, Chen Y, George AM, Abbosh C, Kanu N, Lee SH, McGranahan N, Berg CD, Sasieni P, Houlston R, Turnbull C, Lam S, Awadalla P, Grönroos E, Downward J, Jacks T, Carlsten C, Malanchi I, Hackshaw A, Litchfield K, DeGregori J, Jamal-Hanjani M, Swanton C. Lung adenocarcinoma promotion by air pollutants. Nature. 2023 Apr;616(7955):159-167. PubMed PMID: 37020004

Park HJ, Gregory MA, Zaberezhnyy V, Goodspeed A, Jordan CT, Kieft JS, DeGregori J. Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation. Elife. 2022 Oct 19;11. PubMed PMID: 36259537

Pietras EM, DeGregori J. Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis. Cancer Discov. 2022 Oct 5;12(10):2234-2236. PubMed PMID: 36196576

Braithwaite D, Anton S, Mohile S, DeGregori J, Gillis N, Zhou D, Bloodworth S, Pahor M, Licht J. Cancer and aging: A call to action. Aging Cancer. 2022 Jun;3(2):87-94. PubMed PMID: 36188489

Evans EJ Jr, DeGregori J. Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia. J Clin Invest. 2022 Jul 15;132(14). PubMed PMID: 35838049

Somarelli JA, DeGregori J, Gerlinger M, Heng HH, Marusyk A, Welch DR, Laukien FH. Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes. Med Oncol. 2022 Jul 4;39(9):137. PubMed PMID: 35781581

Marongiu F, DeGregori J. The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging-related disease. Mol Oncol. 2022 Sep;16(18):3238-3258. PubMed PMID: 35726685

Florez MA, Tran BT, Wathan TK, DeGregori J, Pietras EM, King KY. Clonal hematopoiesis: Mutation-specific adaptation to environmental change. Cell Stem Cell. 2022 Jun 2;29(6):882-904. PubMed PMID: 35659875

Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. Resilience integrates concepts in aging research. iScience. 2022 May 20;25(5):104199. PubMed PMID: 35494229

De Dominici M, DeGregori J. Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFN? Signaling to Gain Clonal Advantage. Blood Cancer Discov. 2022 May 5;3(3):178-180. PubMed PMID: 35394495

Evans EJ Jr, DeGregori J. Cells with Cancer-associated Mutations Overtake Our Tissues as We Age. Aging Cancer. 2021 Sep;2(3):82-97. PubMed PMID: 34888527

Chia SB, DeGregori J. Cancer stem cells in the gut have a bad influence on neighbouring cells. Nature. 2021 Jun;594(7863):340-341. PubMed PMID: 34079113

Higa KC, Goodspeed A, Chavez JS, De Dominici M, Danis E, Zaberezhnyy V, Rabe JL, Tenen DG, Pietras EM, DeGregori J. Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors. J Exp Med. 2021 Jun 7;218(6). PubMed PMID: 33914855

Dujon AM, Aktipis A, Alix-Panabières C, Amend SR, Boddy AM, Brown JS, Capp JP, DeGregori J, Ewald P, Gatenby R, Gerlinger M, Giraudeau M, Hamede RK, Hansen E, Kareva I, Maley CC, Marusyk A, McGranahan N, Metzger MJ, Nedelcu AM, Noble R, Nunney L, Pienta KJ, Polyak K, Pujol P, Read AF, Roche B, Sebens S, Solary E, Stanková K, Swain Ewald H, Thomas F, Ujvari B. Identifying key questions in the ecology and evolution of cancer. Evol Appl. 2021 Apr;14(4):877-892. PubMed PMID: 33897809

Chavez JS, Rabe JL, Loeffler D, Higa KC, Hernandez G, Mills TS, Ahmed N, Gessner RL, Ke Z, Idler BM, Niño KE, Kim H, Myers JR, Stevens BM, Davizon-Castillo P, Jordan CT, Nakajima H, Ashton J, Welner RS, Schroeder T, DeGregori J, Pietras EM. PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress. J Exp Med. 2021 Jun 7;218(6). PubMed PMID: 33857288

Liggett LA, Galbraith MD, Smith KP, Sullivan KD, Granrath RE, Enriquez-Estrada B, Kinning KT, Shaw JR, Rachubinski AL, Espinosa JM, DeGregori J. Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation. Blood Adv. 2021 Apr 13;5(7):1791-1796. PubMed PMID: 33787858

Capp JP, DeGregori J, Nedelcu AM, Dujon AM, Boutry J, Pujol P, Alix-Panabières C, Hamede R, Roche B, Ujvari B, Marusyk A, Gatenby R, Thomas F. Group phenotypic composition in cancer. Elife. 2021 Mar 30;10. PubMed PMID: 33784238

Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). PubMed PMID: 33649199

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR Jr, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano ... Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021 Jan;17(1):1-382. PubMed PMID: 33634751

De Dominici M, DeGregori J. Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin. Cancer Discov. 2021 Feb;11(2):227-229. PubMed PMID: 33531425

Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds. Aging Cell. 2021 Feb;20(2):e13309. PubMed PMID: 33480151

De Dominici M, DeGregori J. Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin. Cancer Discov. 2021 Feb;11(2):227-229. PubMed PMID: 33531425

Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds. Aging Cell. 2021 Jan 22;:e13309. [Epub ahead of print] PubMed PMID: 33480151

Ciccarelli FD, DeGregori J. Approaching Cancer Evolution from Different Angles. iScience. 2020 Nov 20;23(11):101661. PubMed PMID: 33134891

DeGregori J, Pharoah P, Sasieni P, Swanton C. Cancer Screening, Surrogates of Survival, and the Soma. Cancer Cell. 2020 Oct 12;38(4):433-437. PubMed PMID: 32946774

Jones CL, Stevens BM, Pollyea DA, Culp-Hill R, Reisz JA, Nemkov T, Gehrke S, Gamboni F, Krug A, Winters A, Pei S, Gustafson A, Ye H, Inguva A, Amaya M, Minhajuddin M, Abbott D, Becker MW, DeGregori J, Smith CA, D'Alessandro A, Jordan CT. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells. Cell Stem Cell. 2020 Nov 5;27(5):748-764.e4. PubMed PMID: 32822582

DeGregori J. The special issue on cancer and evolution: Lessons learned. Evol Appl. 2020 Aug;13(7):1784-1790. PubMed PMID: 32821282

Rozhok AI, DeGregori J. The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis. Evol Appl. 2020 Aug;13(7):1569-1580. PubMed PMID: 32821273

Rozhok AI, Silberman RE, Higa KC, Liggett LA, Amon A, DeGregori J. A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution. Sci Rep. 2020 Jul 22;10(1):12198. PubMed PMID: 32699207

DeGregori J. Aging, inflammation, and HSC. Blood. 2020 Jul 9;136(2):153-154. PubMed PMID: 32645167

Laconi E, Marongiu F, DeGregori J. Cancer as a disease of old age: changing mutational and microenvironmental landscapes. Br J Cancer. 2020 Mar;122(7):943-952. PubMed PMID: 32042067

DeGregori J. Of mice, genes and aging. Haematologica. 2020;105(2):246-248. PubMed PMID: 32005650

Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 Feb 1;37(2):320-326. PubMed PMID: 31642480

Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular biology and evolution of cancer: from discovery to action. Mol Biol Evol. 2019 Oct 23. [Epub ahead of print] PubMed PMID: 31642480

Rozhok A, DeGregori J. Somatic maintenance impacts the evolution of mutation rate. BMC Evol Biol. 2019 Aug 23;19(1):172. PubMed PMID: 31443631

Pham-Danis C, DeGregori J. Studying Cancer Evolution and Therapeutic Responses in Different Organs: The Pros and Cons of a Broad Focus. Cancer Res. 2019 Sep 15;79(18):4582-4584. PubMed PMID: 31439547

Liggett LA, Sharma A, De S, DeGregori J. FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue. G3 (Bethesda). 2019 Sep 4;9(9):2977-2987. PubMed PMID: 31352405

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O'Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A. Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. J Natl Cancer Inst. 2019 Dec 1;111(12):1245-1254. PubMed PMID: 31321426

Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. TNF-a-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood. 2019 Aug 29;134(9):727-740. PubMed PMID: 31311815

Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood. 2019 Jul 25;134(4):389-394. PubMed PMID: 31101624

Rozhok A, DeGregori J. A generalized theory of age-dependent carcinogenesis. Elife. 2019 Apr 29;8. PubMed PMID: 31034356

Bilousova G, DeGregori J. Elimination of unfit cells in young and ageing skin. Nature. 2019 Apr;568(7752):318-319. PubMed PMID: 30980033

Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J. Targeting Glutamine Metabolism and Redox State for Leukemia Therapy. Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. PubMed PMID: 30940653

Higa KC, DeGregori J. Decoy fitness peaks, tumor suppression, and aging. Aging Cell. 2019 Jun;18(3):e12938. PubMed PMID: 30848555

Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D, Collins C, Paola JTD, D'Alessandro A, DeGregori J. Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC. Mol Cancer Res. 2019 Jun;17(6):1351-1364. PubMed PMID: 30808730

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2019 Feb 11;35(2):333-335. PubMed PMID: 30753831

Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program. Cancer Res. 2019 Feb 15;79(4):720-734. PubMed PMID: 30606720

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2018 Nov 12;34(5):724-740.e4. PubMed PMID: 30423294

Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP. Adenoviral vectors transduce alveolar macrophages in lung cancer models. Oncoimmunology. 2018;7(6):e1438105. PubMed PMID: 29872579

Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC. ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer. Oncotarget. 2018 Feb 6;9(10):8823-8835. PubMed PMID: 29507657

Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2018 Feb;58:52-58. PubMed PMID: 28947392

Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28947392

Henry CJ, Nemkov T, Casás-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. 2017 Dec;102(12):1985-1994. PubMed PMID: 28883079

DeGregori J. Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments. Cancer Res. 2017 Nov 15;77(22):6065-6068. PubMed PMID: 28754675

Liggett LA, DeGregori J. Changing mutational and adaptive landscapes and the genesis of cancer. Biochim Biophys Acta. 2017 Apr;1867(2):84-94. PubMed PMID: 28167050

Scarborough HA, Helfrich BA, Casás-Selves M, Schuller AG, Grosskurth SE, Kim J, Tan AC, Chan DC, Zhang Z, Zaberezhnyy V, Bunn PA, DeGregori J. AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition. Clin Cancer Res. 2017 Mar 15;23(6):1531-1541. PubMed PMID: 27663586

Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proc Natl Acad Sci U S A. 2016 Jan 11. [Epub ahead of print] PubMed PMID: 26755588

Zhang G, Scarborough H, Kim J, Rozhok AI, Chen YA, Zhang X, Song L, Bai Y, Fang B, Liu RZ, Koomen J, Tan AC, Degregori J, Haura EB. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Sci Signal. 2016 Oct 18;9(450):rs12. PubMed PMID: 27811184

Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. PubMed PMID: 27791036

Scarborough HA, Helfrich BA, Casás-Selves M, Schuller AG, Grosskurth SE, Kim J, Tan AC, Chan DC, Zhang Z, Zaberezhnyy V, Bunn PA, DeGregori J. AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition. Clin Cancer Res. 2016 Sep 23. [Epub ahead of print] PubMed PMID: 27663586

Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Trisomy 21 consistently activates the interferon response. Elife. 2016 Jul 29;5. PubMed PMID: 27472900

Fernández-Cabezudo MJ, Faour I, Jones K, Champagne DP, Jaloudi MA, Mohamed YA, Bashir G, Almarzooqi S, Albawardi A, Hashim MJ, Roberts TS, El-Salhat H, El-Taji H, Kassis A, O'Sullivan DE, Christensen BC, DeGregori J, Al-Ramadi BK, Rincon M. Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer. JCI Insight. 2016 May 19;1(7). PubMed PMID: 27275014

Yadav VK, DeGregori J, De S. The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection. Nucleic Acids Res. 2016 Mar 18;44(5):2075-84. PubMed PMID: 26883632

Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1050-5. PubMed PMID: 26755588

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. PubMed PMID: 25547679

Scarborough HA, Bunn PA Jr, DeGregori J. Personalized one-two punches for lung cancer. Cell Res. 2015 Mar;25(3):269-70. PubMed PMID: 25547118

Fleenor CJ, Rozhok AI, Zaberezhnyy V, Mathew D, Kim J, Tan AC, Bernstein ID, DeGregori J. Contrasting Roles for C/EBPa and Notch in Irradiation-Induced Multipotent Hematopoietic Progenitor Cell Defects. Stem Cells. 2015 Apr;33(4):1345-58. PubMed PMID: 25546133

Henry CJ, Sedjo RL, Rozhok A, Salstrom J, Ahnen D, Levin TR, D'Agostino R Jr, Haffner S, DeGregori J, Byers T. Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma. BMC Cancer. 2015;15(1):1115. PubMed PMID: 25777438

Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec 1;125(12):4666-80. PubMed PMID: 26551682

Fleenor CJ, Higa K, Weil MM, DeGregori J. Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies. Radiat Res. 2015 Oct;184(4):341-51. PubMed PMID: 26414506

Rozhok AI, DeGregori J. Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8914-21. PubMed PMID: 26195756

Rozhok AI, Wahl GM, DeGregori J. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep;8(9):762-4. PubMed PMID: 26122457

Henry CJ, Sedjo RL, Rozhok A, Salstrom J, Ahnen D, Levin TR, D'Agostino R Jr, Haffner S, DeGregori J, Byers T. Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma. BMC Cancer. 2015 Mar 14;15:123. PubMed PMID: 25884547

Alvarez-Calderon F, DeGregori J. Oncogenic drivers and mitochondrial dependency. Aging (Albany NY). 2015 Mar;7(3):148-9. PubMed PMID: 25868642

Avasarala S, Van Scoyk M, Karuppusamy Rathinam MK, Zerayesus S, Zhao X, Zhang W, Pergande MR, Borgia JA, DeGregori J, Port JD, Winn RA, Bikkavilli RK. PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. J Biol Chem. 2015 May 22;290(21):13479-89. PubMed PMID: 25847239

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. PubMed PMID: 25547679

Scarborough HA, Bunn PA Jr, DeGregori J. Personalized one-two punches for lung cancer. Cell Res. 2015 Mar;25(3):269-70. PubMed PMID: 25547118

Fleenor CJ, Rozhok AI, Zaberezhnyy V, Mathew D, Kim J, Tan AC, Bernstein ID, DeGregori J. Contrasting roles for C/EBPa and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem Cells. 2015 Apr;33(4):1345-58. PubMed PMID: 25546133

Ostrow SL, Barshir R, Degregori J, Yeger-Lotem E, Hershberg R. Cancer evolution is associated with pervasive positive selection on globally expressed genes. PLoS Genet. 2014 Mar;10(3):e1004239. PubMed PMID: 24603726

Wie SM, Adwan TS, Degregori J, Anderson SM, Reyland ME. Inhibiting Tyrosine Phosphorylation of Protein Kinase Cd (PKCd) Protects the Salivary Gland from Radiation Damage. J Biol Chem. 2014 Feb 25. [Epub ahead of print] PubMed PMID: 24569990

Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes. Aging (Albany NY). 2014 Dec;6(12):1033-48. PubMed PMID: 25564763

Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC. Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1( ) leukemia. Am J Hematol. 2014 Sep;89(9):896-903. PubMed PMID: 24891015

Aghili L, Foo J, DeGregori J, De S. Patterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patients. Cell Rep. 2014 May 22;7(4):1310-9. PubMed PMID: 24794429

Ostrow SL, Barshir R, DeGregori J, Yeger-Lotem E, Hershberg R. Cancer evolution is associated with pervasive positive selection on globally expressed genes. PLoS Genet. 2014 Mar;10(3):e1004239. PubMed PMID: 24603726

Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME. Inhibiting tyrosine phosphorylation of protein kinase Cd (PKCd) protects the salivary gland from radiation damage. J Biol Chem. 2014 Apr 11;289(15):10900-8. PubMed PMID: 24569990

Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW. Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. PLoS One. 2013;8(9):e74809. PubMed PMID: 24058630

Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, Degregori JV, Messersmith WA, Winn RA, Eckhardt SG. Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clin Cancer Res. 2013 Aug 1;19(15):4149-62. PubMed PMID: 23757356

Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Mol Pharmacol. 2013 Apr;83(4):882-93. PubMed PMID: 23371912

Gore L, DeGregori J, Porter CC. Targeting developmental pathways in children with cancer: what price success?. Lancet Oncol. 2013 Feb;14(2):e70-8. PubMed PMID: 23369685

Alvarez-Calderon F, Gregory MA, DeGregori J. Using functional genomics to overcome therapeutic resistance in hematological malignancies. Immunol Res. 2013 Mar;55(1-3):100-15. PubMed PMID: 22941562

DeGregori J. Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?. Oncogene. 2013 Apr 11;32(15):1869-75. PubMed PMID: 22751134

Porter, C.C., J. Kim, S. Fosmire, C. M. Gearheart, A. van Linden, D. Baturin, V. Zaberezhnyy, P. R. Patel, D. Gao, A. C. Tan, and J. DeGregori (2011). Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and novel therapeutic target in acute myeloid leukemia. Leukemia, in press.

Casas-Selves, M., Kim, J., Zhang, Z., Helfrich, B., Gao, D., Porter, C. C., Bunn, P. A., Chan, D. C., Tan, A. C., and DeGregori, J. Genome wide shRNA screens reveal that tankyrase and the canonical Wnt pathway protects lung cancer cells from EGFR inhibition. Submitted. (provisionally accepted by Cancer Research, but may be couple of weeks before final decision)

Casas-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA, Jr., Chan DC, Tan AC, DeGregori J (2012). Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res, 72:4154-64.

Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. (2012) ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature Chem Biol, 8:646-54.

Singleton, K. R., Kim, J., Hinz, T. K., Marek, L. A., Casas-Selves, M., Hatheway, C., Tan, A. C., Degregori, J., and Heasley, L. E. (2013). A Receptor Tyrosine Kinase Network Comprised of FGFRs, EGFR, ERBB2 and MET Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines. Molecular pharmacology, in press.

DeGregori J. (2013) Challenging the axiom: Does the occurrence of oncogenic mutations truly limit cancer development with age? Oncogene, 32, 1869–1875 (ePub, June 2012).

Alvarez-Calderon, F., Gregory, M. A., and Degregori, J. (2013). Using functional genomics to overcome therapeutic resistance in hematological malignancies. Immunologic Research 55, 100-115.

Gore, L., Degregori, J., and Porter, C. C. (2013). Targeting developmental pathways in children with cancer: what price success? The Lancet Oncology 14, e70-78.

Fleenor, C., A. Marusyk and J. DeGregori (2010). Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape. Cell Cycle, 9(15):3005-11.

DeGregori, J. (2011). Evolved tumor suppression: why are we so good at not getting cancer? (Perspective) Cancer Research, 71: 3739-3744.

Henry, C.J., A. Marusyk, and J. DeGregori (2011). Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What’s the Connection? (Review) Aging 3:643-56.

DeGregori, J. (2011). A new role for E2F1 in DNA repair: all for the greater good. (Highlight) Cell Cycle. 10:1716.

Casás-Selves, M. and J. DeGregori (2011). How cancer shapes evolution, and how evolution shapes cancer. Evolution: Education and Outreach, 4:624–634.

Alvarez D. F., K. Helm, J. DeGregori, M. Roederer, S. Majka (2010). Publishing flow cytometry data. Am J Physiol Lung Cell Mol Physiol. 298:L127-30.

Marusyk A, C. Porter, V. Zaberezhnyy and J. DeGregori (2010). Irradiation selects for p53 deficient hematopoietic progenitors. PLoS Biology, 8:e1000324..

Alvarez D. F., K. Helm, J. DeGregori, M. Roederer, S. Majka (2010). Publishing flow cytometry data. Am J Physiol Lung Cell Mol Physiol. 298:L127-30.

Marusyk A, C. Porter, V. Zaberezhnyy and J. DeGregori (2010). Irradiation selects for p53 deficient hematopoietic progenitors. PLoS Biology, 8:e1000324.

Le, O., F. Rodier, F. Fontaine, J-P. Coppe, J. Campisi, J. DeGregori, C. Laverdière, V. Kokta, E. Haddad and C. M. Beauséjour. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell, 9, 398–409. Gregory, M., T. Phang, P. Neviani, F. Alvarez-Calderon, V. Zaberezhnyy, R. Williams, T. O’Hare, C. Eide, B. Druker, D. Perrotti and J. DeGregori. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell, 18, 74-87.

Bui, M.R., V. Hodson, T. King, D. Leopold, S. Dai, V. Fiolkoski, S. Oakes, R. Duke, D. Apelian, A. Franzusoff, and J. DeGregori (2010). Mutation Specific Control of BCR-ABL T315I Positive Leukemia with a Recombinant Yeast-Based Therapeutic Vaccine in a Murine Model. Vaccine, 28:6028-35.

Henry, C.J., A. Marusyk, B. Adane, V. Zaberezhnyy and J. DeGregori (2010). Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc. Natl. Acad. Sci. USA, 107: 21713-21718.

Schaack, J., Bennett, M.L., Shapiro, G., DeGregori, J., McManaman, J.L, and Moorhead, J.W. (2011) Strong Foreign Promoters Contribute to Innate Inflammatory Responses Induced by Adenovirus Transducing Vectors. Virology, 28:6028-35..

Porter, C.C., D. Baturin, R. Choudhary and J. DeGregori (2011). The relative fitness of hematopoietic progenitors influences leukemia progression. Leukemia, 25:891-5.

Marusyk A, M. Casás-Selves, C. J. Henry, V. Zaberezhnyy, J. Klawitter, U. Christians and J. DeGregori. (2009) Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Research 69, 7262-7269.

Schlegel J, Redzic JS, Porter CC, Yurchenko V, Bukrinsky M, Armstrong GS, Zhang F, Isern NG, DeGregori J, Hodges R, Eisenmesser EZ. (2009) “Solution characterization of the extracellular region of EMMPRIN/CD147 and its interaction with its enzyme ligand cyclophilin-A”. J Mol Biol., 391(3):518-35.

Marusyk A, M. Casás-Selves, C. J. Henry, V. Zaberezhnyy, J. Klawitter, U. Christians and J. DeGregori. (2009) Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Research 69, 7262-7269.

Schlegel J, Redzic JS, Porter CC, Yurchenko V, Bukrinsky M, Armstrong GS, Zhang F, Isern NG, DeGregori J, Hodges R, Eisenmesser EZ. (2009) “Solution characterization of the extracellular region of EMMPRIN/CD147 and its interaction with its enzyme ligand cyclophilin-A”. J Mol Biol., 391(3):518-35.

Professor, Biochemistry & Molecular Genetics

Languages

Department

Professional Titles

Publications

Professional Memberships

School of Medicine

CU Anschutz

Fitzsimons Building