Ross Kedl, PhD
Professor, Immunology and Microbiology

Publications

  • Torphy RJ, Sun Y, Lin R, Caffrey-Carr A, Fujiwara Y, Ho F, Miller EN, McCarter MD, Lyons TR, Schulick RD, Kedl RM, Zhu Y. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models. Nat Commun. 2022 Jan 10;13(1):97. PubMed PMID: 35013216
  • Windsor WJ, Knight V, Merkel PA, Lamb MM, Tucker HR, Carson K, Howard KM, Yates JL, Santiago ML, McCarthy MK, Morrison TE, Kedl RM, Frazer-Abel A, Guo K, Andersen G, Huey L, Barrett BS, Colón-Franco JM, Lee WT, Chu MC. COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method. Am J Trop Med Hyg. 2022 Jan 7. [Epub ahead of print] PubMed PMID: 34996045
  • Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2021 Dec 3. [Epub ahead of print] PubMed PMID: 34862244
  • Suwanpradid J, Lee MJ, Hoang P, Kwock J, Floyd LP, Smith JS, Yin Z, Atwater AR, Rajagopal S, Kedl RM, Corcoran DL, Zhang JY, MacLeod AS. IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses. Front Immunol. 2021;12:713304. PubMed PMID: 34659203
  • Klarquist J, Cross EW, Thompson SB, Willett B, Aldridge DL, Caffrey-Carr AK, Xu Z, Hunter CA, Getahun A, Kedl RM. B cells promote CD8 T cell primary and memory responses to subunit vaccines. Cell Rep. 2021 Aug 24;36(8):109591. PubMed PMID: 34433030
  • Davenport BJ, Morrison TE, Kedl RM, Klarquist J. Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination. J Immunol. 2021 Jun 1;206(11):2503-2507. PubMed PMID: 33972373
  • Lee W, Kingstad-Bakke B, Kedl RM, Kawaoka Y, Suresh M. CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. J Virol. 2021 Jul 12;95(15):e0053021. PubMed PMID: 33952647
  • Kedl RM. Down but far from out: The durability of SARS-CoV-2 immunity after asymptomatic infection. J Exp Med. 2021 May 3;218(5). PubMed PMID: 33861846
  • Schultz JS, McCarthy MK, Rester C, Sabourin KR, Annen K, DomBourian M, Eisenmesser E, Frazer-Abel A, Knight V, Jaenisch T, Morrison TE, Rochford R, Kedl RM. Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA. J Clin Microbiol. 2021 May 19;59(6). PubMed PMID: 33795412
  • Lee W, Kingstad-Bakke B, Kedl RM, Kawaoka Y, Suresh M. CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. bioRxiv. 2021 Mar 25. PubMed PMID: 33791695
  • Burrack AL, Rollins MR, Spartz EJ, Mesojednik TD, Schmiechen ZC, Raynor JF, Wang IX, Kedl RM, Stromnes IM. CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model. J Immunol. 2021 Mar 15;206(6):1372-1384. PubMed PMID: 33558374
  • Sabourin KR, Schultz J, Romero J, Lamb MM, Larremore D, Morrison TE, Frazer-Abel A, Zimmer S, Kedl RM, Jaenisch T, Rochford R. Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders-The COVID-19 Arapahoe SErosurveillance Study (CASES) Project. J Occup Environ Med. 2021 Mar 1;63(3):191-198. PubMed PMID: 33298759
  • Sabourin KR, Schultz J, Romero J, Lamb MM, Larremore D, Morrison TE, Frazer-Abel A, Zimmer S, Kedl RM, Jaenisch T, Rochford R. Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders - the COVID-19 Arapahoe SErosurveillance Study (CASES) Project. J Occup Environ Med. 2020 Dec 3. [Epub ahead of print] PubMed PMID: 33298759
  • Marinaik CB, Kingstad-Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, Neldner B, Gasper DJ, Kedl RM, Kawaoka Y, Suresh M. Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants. Cell Rep Med. 2020 Sep 22;1(6):100095. PubMed PMID: 32984856
  • Eberlein J, Davenport B, Nguyen TT, Victorino F, Jhun K, van der Heide V, Kuleshov M, Ma'ayan A, Kedl R, Homann D. Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells. J Immunol. 2020 Oct 15;205(8):2169-2187. PubMed PMID: 32948687
  • Davenport B, Eberlein J, Nguyen TT, Victorino F, van der Heide V, Kuleshov M, Ma'ayan A, Kedl R, Homann D. Chemokine Signatures of Pathogen-Specific T Cells II: Memory T Cells in Acute and Chronic Infection. J Immunol. 2020 Oct 15;205(8):2188-2206. PubMed PMID: 32948682
  • Davenport BJ, Bullock C, McCarthy MK, Hawman DW, Murphy KM, Kedl RM, Diamond MS, Morrison TE. Chikungunya Virus Evades Antiviral CD8( ) T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues. J Virol. 2020 Apr 16;94(9). PubMed PMID: 32102875
  • Kilgore AM, Pennock ND, Kedl RM. cDC1 IL-27p28 Production Predicts Vaccine-Elicited CD8( ) T Cell Memory and Protective Immunity. J Immunol. 2020 Feb 1;204(3):510-517. PubMed PMID: 31871021
  • Kilgore AM, Pennock ND, Kedl RM. cDC1 IL-27p28 Production Predicts Vaccine-Elicited CD8( ) T Cell Memory and Protective Immunity. J Immunol. 2019 Dec 23. [Epub ahead of print] PubMed PMID: 31871021
  • Thompson EA, Darrah PA, Foulds KE, Hoffer E, Caffrey-Carr A, Norenstedt S, Perbeck L, Seder RA, Kedl RM, Loré K. Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-ß Release. Cell Rep. 2019 Jul 30;28(5):1127-1135.e4. PubMed PMID: 31365858
  • DeLong JH, O'Hara Hall A, Rausch M, Moodley D, Perry J, Park J, Phan AT, Beiting DP, Kedl RM, Hill JA, Hunter CA. IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. Immunohorizons. 2019 Jan 15;3(1):13-25. PubMed PMID: 31356173
  • Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1255-1267. PubMed PMID: 31040184
  • Pritchard GH, Kedl RM, Hunter CA. The evolving role of T-bet in resistance to infection. Nat Rev Immunol. 2019 Jun;19(6):398-410. PubMed PMID: 30846856
  • Cross EW, Blain TJ, Mathew D, Kedl RM. Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8 T cells. PLoS One. 2019;14(2):e0211446. PubMed PMID: 30735510
  • Kilgore AM, Welsh S, Cheney EE, Chitrakar A, Blain TJ, Kedl BJ, Hunter CA, Pennock ND, Kedl RM. IL-27p28 Production by XCR1( ) Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8( ) T Cell Responses. Immunohorizons. 2018 Jan 1;2(1):1-11. PubMed PMID: 29354801
  • Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM. Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis. Sci Immunol. 2018 Sep 7;3(27). PubMed PMID: 30194241
  • Atif SM, Gibbings SL, Redente EF, Camp FA, Torres RM, Kedl RM, Henson PM, Jakubzick CV. Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity. Am J Respir Cell Mol Biol. 2018 Nov;59(5):580-591. PubMed PMID: 29953261
  • Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL. Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest. 2018 Jun 1;128(6):2535-2550. PubMed PMID: 29757193
  • Homann D, Kedl RM. Dimensions of immunologic memory. Immunol Rev. 2018 May;283(1):5-6. PubMed PMID: 29664575
  • Kedl RM, White JT. Foreign antigen-independent memory-phenotype CD4( ) T cells: a new player in innate immunity?. Nat Rev Immunol. 2018 Feb 26;18(3):1. PubMed PMID: 29480288
  • Kilgore AM, Welsh S, Cheney EE, Chitrakar A, Blain TJ, Kedl BJ, Hunter CA, Pennock ND, Kedl RM. IL-27p28 Production by XCR1( ) Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8( ) T Cell Responses. Immunohorizons. 2018 Jan 1;2(1):1-11. PubMed PMID: 29354801
  • Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul;17(7):1742-1753. PubMed PMID: 28066981
  • Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML. Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction. Retrovirology. 2017 Apr 17;14(1):25. PubMed PMID: 28415995
  • White JT, Cross EW, Kedl RM. Antigen-inexperienced memory CD8( ) T cells: where they come from and why we need them. Nat Rev Immunol. 2017 Jun;17(6):391-400. PubMed PMID: 28480897
  • Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA. Corrigendum: Spontaneous partial loss of the OT-I transgene. Nat Immunol. 2017 Jul 19;18(8):951. PubMed PMID: 28722721
  • Kedl RM, Seder R. Editorial overview: Vaccines. Curr Opin Immunol. 2017 Aug;47:A1-A2. PubMed PMID: 28969845
  • Kedl RM, Lindsay RS, Finlon JM, Lucas ED, Friedman RS, Tamburini BAJ. Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction. Nat Commun. 2017 Dec 11;8(1):2034. PubMed PMID: 29229919
  • Kedl JD, Kedl RM. How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18. Eur J Immunol. 2015 Feb;45(2):376-9. PubMed PMID: 25641415
  • Kedl RM, Tamburini BA. Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium. Eur J Immunol. 2015 Oct;45(10):2721-9. PubMed PMID: 26278423
  • Burchill MA, Tamburini BA, Kedl RM. T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs. Eur J Immunol. 2015 Nov;45(11):3140-9. PubMed PMID: 26179759
  • Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Loré K. Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates. J Immunol. 2015 Aug 1;195(3):1015-24. PubMed PMID: 26123354
  • Atif SM, Nelsen MK, Gibbings SL, Desch AN, Kedl RM, Gill RG, Marrack P, Murphy KM, Grazia TJ, Henson PM, Jakubzick CV. Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. J Immunol. 2015 Jul 1;195(1):46-50. PubMed PMID: 26034174
  • Kedl JD, Kedl RM. How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18. Eur J Immunol. 2015 Feb;45(2):376-9. PubMed PMID: 25641415
  • Tamburini BA, Burchill MA, Kedl RM. Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection. Nat Commun. 2014 Jun 6;5:3989. PubMed PMID: 24905362
  • Christie M, Torres RM, Kedl RM, Randolph TW, Carpenter JF. Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. J Pharm Sci. 2014 Jan;103(1):128-39. PubMed PMID: 25133276
  • Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19;5:4674. PubMed PMID: 25135627
  • Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. PubMed PMID: 25267651
  • Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15;193(10):4757-60. PubMed PMID: 25381356
  • Pennock ND, White JT, Cross EW, Cheney EE, Tamburini BA, Kedl RM. T cell responses: naive to memory and everything in between. Adv Physiol Educ. 2013 Dec;37(4):273-83. PubMed PMID: 24292902
  • Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP. Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013 Aug;49(2):316-23. PubMed PMID: 23590301
  • Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a dendritic cell trans presentation of IL-15 to naive CD8 T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 1;190(5):1936-47. PubMed PMID: 23355737
  • Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 1;190(5):2090-101. PubMed PMID: 23335750
  • Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 1;190(3):913-21. PubMed PMID: 23275606
  • Burchill MA, Tamburini BA, Pennock ND, White JT, Kurche JS, Kedl RM. T cell vaccinology: exploring the known unknowns. Vaccine. 2013 Jan 2;31(2):297-305. PubMed PMID: 23137843
  • Edwards LE, Haluszczak C, Kedl RM. Phenotype and function of protective, CD4-independent CD8 T cell memory. Immunol Res. 2013 Mar;55(1-3):135-45. PubMed PMID: 22948808
  • Friend SF, Peterson LK, Kedl RM, Dragone LL. SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8 T cells. Immunol Res. 2013 Mar;55(1-3):116-24. PubMed PMID: 22956467
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General Information

Department: Immunology and Microbiology
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