Lorna Moore, PhD
Professor, Ob/Gyn-Basic Repro Science

Publications

  • Moore LG. HYPOXIA AND REPRODUCTIVE HEALTH: Reproductive challenges at high altitude: fertility, pregnancy and neonatal well-being. Reproduction. 2021 Jan;161(1):F81-F90. PubMed PMID: 33112770
  • Lorca RA, Houck JA, Laurent LC, Matarazzo CJ, Baker K, Horii M, Nelson KK, Bales ES, Euser AG, Parast MM, Moore LG, Julian CG. High altitude regulates the expression of AMPK pathways in human placenta. Placenta. 2021 Jan 15;104:267-276. PubMed PMID: 33472134
  • Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep;9(18):e15033. PubMed PMID: 34558219
  • Rosario FJ, Pardo S, Michelsen TM, Erickson K, Moore L, Powell TL, Weintraub ST, Jansson T. Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture. Front Cell Dev Biol. 2021;9:704781. PubMed PMID: 34595166
  • Moore LG. How hypoxia slows fetal growth: insights from high altitude. Pediatr Res. 2021 Oct 14. [Epub ahead of print] PubMed PMID: 34650197
  • Moore LG. REPRODUCTIVE CHALLENGES AT HIGH ALTITUDE: fertility, pregnancy and neonatal well-being. Reproduction. 2020 Sep 1. [Epub ahead of print] PubMed PMID: 33112770
  • Grant I, Soria R, Julian CG, Vargas E, Moore LG, Aiken CE, Giussani DA. Parental ancestry and risk of early pregnancy loss at high altitude. FASEB J. 2020 Oct;34(10):13741-13749. PubMed PMID: 32856356
  • Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow. J Physiol. 2020 Sep;598(18):4093-4105. PubMed PMID: 32592403
  • Lorca RA, Matarazzo CJ, Bales ES, Houck JA, Orlicky DJ, Euser AG, Julian CG, Moore LG. AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H203-H212. PubMed PMID: 32502374
  • Bailey B, Euser AG, Bol KA, Julian CG, Moore LG. High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy. J Matern Fetal Neonatal Med. 2020 Mar 30;:1-8. [Epub ahead of print] PubMed PMID: 32228111
  • Määttä J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P. Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2020 Mar 3;10(1):4260. PubMed PMID: 32123262
  • Lamale-Smith LM, Gumina DL, Kramer AW, Browne VA, Toledo-Jaldin L, Julian CG, Winn VD, Moore LG. Uteroplacental Ischemia Is Associated with Increased PAPP-A2. Reprod Sci. 2020 Feb;27(2):529-536. PubMed PMID: 31994005
  • Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 Mar;34(3):4283-4292. PubMed PMID: 31970838
  • Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 1;128(1):127-133. PubMed PMID: 31804891
  • Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction†. Biol Reprod. 2020 Mar 13;102(3):660-670. PubMed PMID: 31711123
  • Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction. Biol Reprod. 2019 Nov 11. [Epub ahead of print] PubMed PMID: 31711123
  • Bailey BA, Donnelly M, Bol K, Moore LG, Julian CG. High Altitude Continues to Reduce Birth Weights in Colorado. Matern Child Health J. 2019 Nov;23(11):1573-1580. PubMed PMID: 31243627
  • Toledo-Jaldin L, Bull S, Contag S, Escudero C, Gutierrez P, Heath A, Roberts JM, Scandlyn J, Julian CG, Moore LG. Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia. Pregnancy Hypertens. 2019 Apr;16:139-144. PubMed PMID: 31056149
  • Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 Aug;33(8):8999-9007. PubMed PMID: 31039323
  • Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 Jun;73(6):1319-1326. PubMed PMID: 31006328
  • Julian CG, Moore LG. Human Genetic Adaptation to High Altitude: Evidence from the Andes. Genes (Basel). 2019 Feb 15;10(2). PubMed PMID: 30781443
  • Bailey BA, Donnelly M, Bol K, Moore LG, Julian CG. High Altitude Continues to Reduce Birth Weights in Colorado. Matern Child Health J. 2019 Nov;23(11):1573-1580. PubMed PMID: 31243627
  • Toledo-Jaldin L, Bull S, Contag S, Escudero C, Gutierrez P, Heath A, Roberts JM, Scandlyn J, Julian CG, Moore LG. Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia. Pregnancy Hypertens. 2019 Apr;16:139-144. PubMed PMID: 31056149
  • Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 Aug;33(8):8999-9007. PubMed PMID: 31039323
  • Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 Jun;73(6):1319-1326. PubMed PMID: 31006328
  • Julian CG, Moore LG. Human Genetic Adaptation to High Altitude: Evidence from the Andes. Genes (Basel). 2019 Feb 15;10(2). PubMed PMID: 30781443
  • Määttä J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P. Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2018 Sep 11;8(1):13583. PubMed PMID: 30206264
  • Moore LG. Queen of the mountain: successful pregnancy while exercising up to 5,300 m. J Appl Physiol (1985). 2018 Aug 1;125(2):577-579. PubMed PMID: 30001156
  • Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R. Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2a) polymorphism lowers hemoglobin concentration in Tibetan highlanders. J Mol Med (Berl). 2017 Jun;95(6):665-670. PubMed PMID: 28233034
  • Crawford JE, Amaru R, Song J, Julian CG, Racimo F, Cheng JY, Guo X, Yao J, Ambale-Venkatesh B, Lima JA, Rotter JI, Stehlik J, Moore LG, Prchal JT, Nielsen R. Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans. Am J Hum Genet. 2017 Nov 2;101(5):752-767. PubMed PMID: 29100088
  • Moore LG. Measuring high-altitude adaptation. J Appl Physiol (1985). 2017 Nov 1;123(5):1371-1385. PubMed PMID: 28860167
  • Wolfson G, Vargas E, Browne VA, Moore LG, Julian CG. Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High Altitude Pregnancy. J Clin Endocrinol Metab. 2016 Nov 3;:jc20161767. [Epub ahead of print] PubMed PMID: 27809650
  • Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG. Hypoxia, AMPK activation and uterine artery vasoreactivity. J Physiol. 2016 Mar 1;594(5):1357-69. PubMed PMID: 26110512
  • Niermeyer S, Andrade-M MP, Vargas E, Moore LG. Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitude (2013 Grover Conference series). Pulm Circ. 2015 Mar;5(1):48-62. PubMed PMID: 25992270
  • Pomeroy E, Wells JC, Stanojevic S, Miranda JJ, Moore LG, Cole TJ, Stock JT. Surname-inferred Andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level. Am J Hum Biol. 2015 Nov-Dec;27(6):798-806. PubMed PMID: 25960137
  • Browne VA, Julian CG, Toledo-Jaldin L, Cioffi-Ragan D, Vargas E, Moore LG. Uterine artery blood flow, fetal hypoxia and fetal growth. Philos Trans R Soc Lond B Biol Sci. 2015 Mar 5;370(1663):20140068. PubMed PMID: 25602072
  • Osol G, Moore LG. Maternal uterine vascular remodeling during pregnancy. Microcirculation. 2014 Jan;21(1):38-47. PubMed PMID: 23941526
  • Julian CG, Yang IV, Browne VA, Vargas E, Rodriguez C, Pedersen BS, Moore LG, Schwartz DA. Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J. 2013 Dec 4. [Epub ahead of print] PubMed PMID: 24307415
  • Soria R, Julian CG, Vargas E, Moore LG, Giussani DA. Graduated effects of high-altitude hypoxia and highland ancestry on birth size. Pediatr Res. 2013 Dec;74(6):633-8. PubMed PMID: 23999073
  • Schwartz J, Cioffi-Ragan D, Wilson MJ, Julian CG, Beatty B, Moore LG, Galan HL. Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation. Am J Hum Biol. 2013 Jul-Aug;25(4):544-9. PubMed PMID: 23754523
  • Gabory A, Roseboom TJ, Moore T, Moore LG, Junien C. Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. Biol Sex Differ. 2013 Mar 21;4(1):5. PubMed PMID: 23514128
  • Julian CG, Vargas E, Gonzales M, Dávila RD, Ladenburger A, Reardon L, Schoo C, Powers RW, Lee-Chiong T, Moore LG. Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis). Respir Physiol Neurobiol. 2013 Apr 1;186(2):188-96. PubMed PMID: 23380170
  • Bigham AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD. Andean and Tibetan patterns of adaptation to high altitude. Am J Hum Biol. 2013 Mar-Apr;25(2):190-7. PubMed PMID: 23348729
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General Information

Department: Ob/Gyn-Basic Repro Science
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13001 East 17th Place
Campus Box C290
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