Carlyne Cool, MD
Clinical Professor, Pathology

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Medical School:
  • MD, University of Colorado Denver School of Medicine (1992)
Undergraduate School:
  • BS, North Dakota State University (ND) (1983)
Internship:
  • University of Colorado (University Hospital) Program (1993)
Residency:
  • University of Colorado, Chief Resident, Pathology (1997)
Languages: English
Department: Pathology

Publications

  • Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, Goncharova E, Yoder MC, Clauss M, Freishtat R, Farkas L. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. Sci Rep. 2020 Jan 24;10(1):1136. PubMed PMID: 31980720
  • Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H, Cole JE, Sabroe I, Monaco C, Cool CD, Goncharova EA, Lawrie A, Farkas L. Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 Jan 15;199(2):199-210. PubMed PMID: 30211629
  • Solomon JJ, Matson S, Kelmenson LB, Chung JH, Hobbs SB, Rosas IO, Dellaripa PF, Doyle TJ, Poli S, Esposito AJ, Visser A, Marin AI, Amigues I, Fernández Pérez ER, Brown KK, Mahler M, Heinz D, Cool C, Deane KD, Swigris JJ, Demoruelle MK. IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis. Chest. 2019 Dec 23. [Epub ahead of print] PubMed PMID: 31877269
  • Kurche JS, Dobrinskikh E, Hennessy CE, Huber J, Estrella A, Hancock LA, Schwarz MI, Okamoto T, Cool CD, Yang IV, Evans CM, Schwartz DA. Muc5b Enhances Murine Honeycomb-like Cyst Formation. Am J Respir Cell Mol Biol. 2019 Oct;61(4):544-546. PubMed PMID: 31573335
  • He C, Lee JS, Cool CD, Wicklund MP, Fischer A. Development of Autoimmune Interstitial Lung Disease in a Patient with Inclusion Body Myositis. Am J Med. 2019 Dec;132(12):e854-e855. PubMed PMID: 31310746
  • Tuder RM, Cool CD. Pulmonary Arteries and Microcirculation in COPD With Pulmonary Hypertension: Bystander or Culprit?. Chest. 2019 Jul;156(1):4-6. PubMed PMID: 31279376
  • Bhagwani AR, Hultman S, Farkas D, Moncayo R, Dandamudi K, Zadu AK, Cool CD, Farkas L. Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension. PLoS One. 2019;14(3):e0213890. PubMed PMID: 30883593
  • Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H, Cole JE, Sabroe I, Monaco C, Cool CD, Goncharova EA, Lawrie A, Farkas L. Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 Jan 15;199(2):199-210. PubMed PMID: 30211629
  • Niemeyer BF, Oko LM, Medina EM, Oldenburg DG, White DW, Cool CD, Clambey ET, van Dyk LF. Host Tumor Suppressor p18(INK4c) functions as a potent cell-intrinsic inhibitor of ?HV68 reactivation and pathogenesis. J Virol. 2018 Jan 3. [Epub ahead of print] PubMed PMID: 29298882
  • Choi SH, Wallace AM, Schneider DA, Burg E, Kim J, Alekseeva E, Ubags ND, Cool CD, Fang L, Suratt BT, Miller YI. AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation. JCI Insight. 2018 Aug 23;3(16). [Epub ahead of print] PubMed PMID: 30135304
  • Bamberg A, Redente EF, Groshong SD, Tuder RM, Cool CD, Keith RC, Edelman BL, Black BP, Cosgrove GP, Wynes MW, Curran-Everett D, De Langhe S, Ortiz LA, Thorburn A, Riches DWH. Protein Tyrosine Phosphatase-N13 Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2018 Oct 1;198(7):914-927. PubMed PMID: 29727583
  • Okamoto T, Mathai SK, Hennessy CE, Hancock LA, Walts AD, Stefanski AL, Brown KK, Lynch DA, Cosgrove GP, Groshong SD, Cool CD, Schwarz MI, Banda NK, Thurman JM, Yang IV, Holers VM, Schwartz DA. The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L1-L10. PubMed PMID: 29565179
  • Krefft SD, Cool CD, Rose CS. The emerging spectrum of exposure-related bronchiolitis. Curr Opin Allergy Clin Immunol. 2018 Apr;18(2):87-95. PubMed PMID: 29394172
  • Niemeyer BF, Oko LM, Medina EM, Oldenburg DG, White DW, Cool CD, Clambey ET, van Dyk LF. Host Tumor Suppressor p18(INK4c) Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. J Virol. 2018 Mar 15;92(6). PubMed PMID: 29298882
  • Ramakrishnan VR, Gonzalez JR, Cooper SE, Barham HP, Anderson CB, Larson ED, Cool CD, Diller JD, Jones K, Kinnamon SC. RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis. Am J Rhinol Allergy. 2017 Sep 1;31(5):283-288. PubMed PMID: 28859701
  • Mizuno S, Ishizaki T, Kadowaki M, Akai M, Shiozaki K, Iguchi M, Oikawa T, Nakagawa K, Osanai K, Toga H, Gomez-Arroyo J, Kraskauskas D, Cool CD, Bogaard HJ, Voelkel NF. p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD. Chest. 2017 Jul;152(1):58-69. PubMed PMID: 28315337
  • Bikkavilli RK, Zerayesus SA, Van Scoyk M, Wilson L, Wu PY, Baskaran A, Tang K, Raheem S, Samuelson BA, Reddy NM, Reddy SP, Cool CD, Kosmider B, Avasarala S, Winn RA. K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer. J Biol Chem. 2017 May 5;292(18):7423-7434. PubMed PMID: 28275056
  • Galambos C, Sims-Lucas S, Abman SH, Cool CD. Intrapulmonary Bronchopulmonary Anastomoses and Plexiform Lesions in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 Mar 1;193(5):574-6. PubMed PMID: 26930433
  • Browning ET, Huckleberry JM, Barrow WB, Restauri NL, Kemme DJ, Cool CD, Weyant MJ, Franklin WA, Camidge DR. Downstaging of Non-Small-Cell Lung Cancer Through Identification of Reversible Drug Toxicity. J Clin Oncol. 2016 Jan 10;34(2):e6-8. PubMed PMID: 24799494
  • Steele MP, Luna LG, Coldren CD, Murphy E, Hennessy CE, Heinz D, Evans CM, Groshong S, Cool C, Cosgrove GP, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Yang IV. Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. BMC Genomics. 2015 Oct 26;16(1):869. PubMed PMID: 26503507
  • Bikkavilli RK, Avasarala S, Van Scoyk M, Arcaroli J, Brzezinski C, Zhang W, Edwards MG, Rathinam MK, Zhou T, Tauler J, Borowicz S, Lussier YA, Parr BA, Cool CD, Winn RA. Wnt7a is a novel inducer of ß-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene. 2015 Oct 16;34(42):5406. PubMed PMID: 26473947
  • Bikkavilli RK, Avasarala S, Van Scoyk M, Arcaroli J, Brzezinski C, Zhang W, Edwards MG, Rathinam MK, Zhou T, Tauler J, Borowicz S, Lussier YA, Parr BA, Cool CD, Winn RA. Wnt7a is a novel inducer of ß-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene. 2015 Oct 16;34(42):5317-28. PubMed PMID: 25728679
  • Diebel KW, Oko LM, Medina EM, Niemeyer BF, Warren CJ, Claypool DJ, Tibbetts SA, Cool CD, Clambey ET, van Dyk LF. Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo. MBio. 2015 Feb 17;6(1):e01670-14. PubMed PMID: 25691585
  • Chung JH, Chawla A, Peljto AL, Cool CD, Groshong SD, Talbert JL, McKean DF, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Lynch DA. CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis. Chest. 2015 Feb;147(2):450-9. PubMed PMID: 25317858
  • Farkas D, Kraskauskas D, Drake JI, Alhussaini AA, Kraskauskiene V, Bogaard HJ, Cool CD, Voelkel NF, Farkas L. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit( ) cells in rats. PLoS One. 2014;9(2):e89810. PubMed PMID: 24587052
  • Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. IL-32 promotes angiogenesis. J Immunol. 2014 Jan 15;192(2):589-602. PubMed PMID: 24337385
  • Anathy V, Aesif SW, Hoffman SM, Bement JL, Guala AS, Lahue KG, Leclair LW, Suratt BT, Cool CD, Wargo MJ, Janssen-Heininger YM. Glutaredoxin-1 Attenuates S-Glutathionylation of the Death Receptor Fas and Decreases Resolution of Pseudomonas aeruginosa Pneumonia. Am J Respir Crit Care Med. 2014 Feb 15;189(4):463-74. PubMed PMID: 24325366
  • Chung JH, Chawla A, Peljto AL, Cool C, Groshong SD, Talbert JL, McKean D, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Lynch DA. CT findings of probable UIP have a high predictive value for histologic UIP. Chest. 2014 Oct 9. [Epub ahead of print] PubMed PMID: 25317858
  • Browning ET, Huckleberry JM, Barrow WB, Restauri NL, Kemme DJ, Cool CD, Weyant MJ, Franklin WA, Camidge DR. Downstaging of Non-Small-Cell Lung Cancer Through Identification of Reversible Drug Toxicity. J Clin Oncol. 2014 May 5. [Epub ahead of print] PubMed PMID: 24799494
  • Farkas D, Alhussaini AA, Kraskauskas D, Kraskauskiene V, Cool CD, Nicolls MR, Natarajan R, Farkas L. Nuclear factor ?B inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats. Am J Respir Cell Mol Biol. 2014 Sep;51(3):413-25. PubMed PMID: 24684441
  • Farkas D, Kraskauskas D, Drake JI, Alhussaini AA, Kraskauskiene V, Bogaard HJ, Cool CD, Voelkel NF, Farkas L. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit? cells in rats. PLoS One. 2014;9(2):e89810. PubMed PMID: 24587052
  • Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. IL-32 promotes angiogenesis. J Immunol. 2014 Jan 15;192(2):589-602. PubMed PMID: 24337385
  • Anathy V, Aesif SW, Hoffman SM, Bement JL, Guala AS, Lahue KG, Leclair LW, Suratt BT, Cool CD, Wargo MJ, Janssen-Heininger YM. Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2014 Feb 15;189(4):463-74. PubMed PMID: 24325366
  • Solomon JJ, Ryu JH, Tazelaar HD, Myers JL, Tuder R, Cool CD, Curran-Everett D, Fischer A, Swigris JJ, Brown KK. Fibrosing interstitial pneumonia predicts survival in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Respir Med. 2013 Aug;107(8):1247-52. PubMed PMID: 23791462
  • Yang IV, Coldren CD, Leach SM, Seibold MA, Murphy E, Lin J, Rosen R, Neidermyer AJ, McKean DF, Groshong SD, Cool C, Cosgrove GP, Lynch DA, Brown KK, Schwarz MI, Fingerlin TE, Schwartz DA. Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis. Thorax. 2013 Dec;68(12):1114-21. PubMed PMID: 23783374
  • Horita H, Furgeson SB, Ostriker A, Olszewski KA, Sullivan T, Villegas LR, Levine M, Parr JE, Cool CD, Nemenoff RA, Weiser-Evans MC. Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension. J Am Heart Assoc. 2013 May 31;2(3):e000188. PubMed PMID: 23727701
  • Kratzer A, Chu HW, Salys J, Moumen Z, Leberl M, Bowler R, Cool C, Zamora M, Taraseviciene-Stewart L. Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD. J Pathol. 2013 Aug;230(4):388-98. PubMed PMID: 23649916
  • Kratzer A, Salys J, Nold-Petry C, Cool C, Zamora M, Bowler R, Koczulla AR, Janciauskiene S, Edwards MG, Dinarello CA, Taraseviciene-Stewart L. Role of IL-18 in second-hand smoke-induced emphysema. Am J Respir Cell Mol Biol. 2013 Jun;48(6):725-32. PubMed PMID: 23392573
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Professional Memberships

  • College of American Pathologists, Member
  • Colorado Society of Clinical Pathologists, Member
  • Academy of Clinical Laboratory Physicians and Scientists, Associate Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Longs Peak Hospital
1750 E. Ken Pratt Boulevard
Longmont, CO 80504
720-718-7000

Hospital Affiliation
  • University of Colorado Hospital
  • National Jewish Health
  • Veterans Affairs Medical Center

Specialty Information

Specialties
  • Anatomic and Clinical, Board Certification (1998)
  • Pathology, Board Certification
  • Anatomic, Board Certification
Conditions & Treatments
  • Lungs and Breathing - Interstitial Lung Disease
  • Lungs and Breathing - Granulomatous Lung Disease
  • Lungs and Breathing - Lung Disease
  • Lungs and Breathing

General Information

Medical Schools:
  • MD, University of Colorado Denver School of Medicine (1992)
Undergraduate Schools:
  • BS, North Dakota State University (ND) (1983)
Internships:
  • University of Colorado (University Hospital) Program (1993)
Residency Programs:
  • University of Colorado, Chief Resident, Pathology (1997)
Download CV
Languages: English
Department: Pathology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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