Bruce Appel, PhD
Professor, Pediatrics-Developmental Biology

Professional Titles

• Professor of Pediatrics
• Diane G. Wallach Chair of Pediatric Stem Cell Biology
• Section Head, Developmental Biology

Teaching

Publications

• Synchronicity in zebrafish locomotive circuit development mediated by electrical pacemaker interneurons Kaleb D. Miles, Chase M. Barker, Bruce H. Appel, Caleb A. Doll bioRxiv 2023.08.25.554828; doi: https://doi.org/10.1101/2023.08.25.554828
• Fedder-Semmes KN, Appel B. The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation. J Neurosci. 2021 Oct 13;41(41):8532-8544. PubMed PMID: 34475201
• Scott K, O'Rourke R, Winkler CC, Kearns CA, Appel B. Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Dev Biol. 2021 Nov;479:37-50. PubMed PMID: 34303700
• Doll CA, Scott K, Appel B. Fmrp regulates oligodendrocyte lineage cell specification and differentiation. Glia. 2021 Oct;69(10):2349-2361. PubMed PMID: 34110049
• Kearns CA, Walker M, Ravanelli AM, Scott K, Arzbecker MR, Appel B. Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 2021 Aug 9;218(4). PubMed PMID: 34057474
• Yergert KM, Doll CA, O'Rouke R, Hines JH, Appel B. Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo. PLoS Biol. 2021 Jan;19(1):e3001053. PubMed PMID: 33439856
• Doll CA, Yergert KM, Appel BH. The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth. Glia. 2020 Mar;68(3):495-508. PubMed PMID: 31626382
• Jewett CE, Appel BH, Prekeris R. The Rab11 effectors Fip5 and Fip1 regulate zebrafish intestinal development. Biol Open. 2020 Oct 23;9(10). PubMed PMID: 32973079
• Scott K, O'Rourke R, Gillen A, Appel B. Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating the Shh signaling response. Development. 2020 Aug 27;147(16). PubMed PMID: 32680935
• Hughes AN, Appel B. Microglia phagocytose myelin sheaths to modify developmental myelination. Nat Neurosci. 2020 Sep;23(9):1055-1066. PubMed PMID: 32632287
• Doll CA, Yergert KM, Appel BH. The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth. Glia. 2020 Mar;68(3):495-508. PubMed PMID: 31626382
• Hughes AN, Appel B. Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nat Commun. 2019 Sep 11;10(1):4125. PubMed PMID: 31511515
• Ravanelli AM, Kearns CA, Powers RK, Wang Y, Hines JH, Donaldson MJ, Appel B. Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signaling. Dev Biol. 2018 Dec 15;444(2):93-106. PubMed PMID: 30347186
• Quintana AM, Yu HC, Brebner A, Pupavac M, Geiger EA, Watson A, Castro VL, Cheung W, Chen SH, Watkins D, Pastinen T, Skovby F, Appel B, Rosenblatt DS, Shaikh TH. Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Hum Mol Genet. 2017 Aug 1;26(15):2838-2849. PubMed PMID: 28449119
• Hughes EG, Appel B. The cell biology of CNS myelination. Curr Opin Neurobiol. 2016 Aug;39:93-100. PubMed PMID: 27152449
• Appel B. Myelination: Both Mindful and Mindless?. Curr Biol. 2016 Jun 6;26(11):R468-70. PubMed PMID: 27269724
• Mathews ES, Appel B. Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling. J Neurosci. 2016 Jul 20;36(29):7628-39. PubMed PMID: 27445141
• Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016 Jul 1;143(13):2292-304. PubMed PMID: 27226318
• Ravanelli AM, Appel B. Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment. Genes Dev. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26584621
• Kearns CA, Ravanelli AM, Cooper K, Appel B. Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. J Neurosci. 2015 Nov 4;35(44):14861-71. PubMed PMID: 26538655
• Hines JH, Ravanelli AM, Schwindt R, Scott EK, Appel B. Neuronal activity biases axon selection for myelination in vivo. Nat Neurosci. 2015 May;18(5):683-9. PubMed PMID: 25849987
• Yang ML, Shin J, Kearns CA, Langworthy MM, Snell H, Walker MB, Appel B. CNS myelination requires cytoplasmic dynein function. Dev Dyn. 2015 Feb;244(2):134-45. PubMed PMID: 25488883
• Wang Y, Pan L, Moens CB, Appel B. Notch3 establishes brain vascular integrity by regulating pericyte number. Development. 2014 Jan;141(2):307-17. PubMed PMID: 24306108
• Yang ML, Shin J, Kearns CA, Langworthy MM, Snell H, Walker MB, Appel B. CNS Myelination Requires Cytoplasmic Dynein Function. Dev Dyn. 2014 Dec 8. [Epub ahead of print] PubMed PMID: 25488883
• Quintana AM, Geiger EA, Achilly N, Rosenblatt DS, Maclean KN, Stabler SP, Artinger KB, Appel B, Shaikh TH. Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression. Dev Biol. 2014 Dec 1;396(1):94-106. PubMed PMID: 25281006
• Blasky AJ, Pan L, Moens CB, Appel B. Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination. Dev Dyn. 2014 Dec;243(12):1511-23. PubMed PMID: 25130183
• Mathews ES, Mawdsley DJ, Walker M, Hines JH, Pozzoli M, Appel B. Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. J Neurosci. 2014 Feb 26;34(9):3402-12. PubMed PMID: 24573296
• Wang Y, Pan L, Moens CB, Appel B. Notch3 establishes brain vascular integrity by regulating pericyte number. Development. 2014 Jan;141(2):307-17. PubMed PMID: 24306108
• Hudish LI, Blasky AJ, Appel B. miR-219 regulates neural precursor differentiation by direct inhibition of apical par polarity proteins. Dev Cell. 2013 Nov 25;27(4):387-98. PubMed PMID: 24239515
• Langworthy MM, Appel B. Schwann cell myelination requires Dynein function. Neural Dev. 2012 Nov 20;7:37. PubMed PMID: 23167977
• Snyder JL, Kearns CA, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012 May 3;7:15. PubMed PMID: 22554084
• Simmons T, Appel B. Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS One. 2012;7(2):e32317. PubMed PMID: 22384214
• Jao LE, Appel B, Wente SR. A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development. 2012 Apr;139(7):1316-26. PubMed PMID: 22357925
• Zannino DA, Sagerström CG, Appel B. olig2-Expressing hindbrain cells are required for migrating facial motor neurons. Dev Dyn. 2012 Feb;241(2):315-26. PubMed PMID: 22275004
• Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 6;287(2):1600-8. PubMed PMID: 22128191
• Distinct and redundant roles for zebrafish her genes during osteoblast differentiation and craniofacial patterning. Amanda Stenzel, Juliana Sucharov, Abigail Mumme-Monheit, Macie Walker, Bruce Appel, James T. Nichols. Frontiers in Endocrinology
• Elizabeth A. Terhune*1, Melissa T. Cuevas*1, Xiaomi Chen1, Maria V. Cattel1, Cambria I. Wethey1, Anna M. Monley1,2, Morgan R. Bland1, Brittan Sutphin1, G. Devon Trahan3, Matthew R.G. Taylor4, Lee A. Niswander3,5, Kenneth L. Jones3, Erin E. Baschal1, Lilian Atunes6, Matthew Dobbs6, Christina Gurnett7, Bruce Appel3, Ryan Gray8, Nancy Hadley Miller1. Mutations in KIF7 Implicated in Idiopathic Scoliosis in Humans and Axial Curvatures in Zebrafish. Human Mutation
• Katie M. Yergert1, Caleb A. Doll1, Rebecca O’Rouke1, Jacob H. Hines2 and Bruce Appel*1. Identification of 3’ UTR motifs required for mRNA localization to myelin sheaths in vivo. PLoS Biology