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Mark Twite, MD
Professor, Anesthesiology-Pediatric Anesthesiology

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Medical School:
  • MD, Royal College of Pediatrics and Child Health, UK (1998)
Residency:
  • University of Colorado, Anesthesiology (2006)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Critical Care Medicine (2003)
Languages: English
Department: Anesthesiology-Pediatric Anesthesiology

Professional Titles

  • Director of Pediatric Cardiac Anesthesia

Publications

  • Frank BS, Nandy D, Khailova L, Mitchell MB, Morgan GJ, Twite M, DiMaria MV, Davidson JA. Circulating biomarkers of extracellular matrix dysregulation are associated with adverse post-stage 2 outcomes in infants with single ventricle heart disease. Sci Rep. 2023 Sep 28;13(1):16318. PubMed PMID: 37770592
  • Twite MD, Nasr VG. Global training pathways in congenital cardiac anesthesiology. Paediatr Anaesth. 2023 Sep 12. [Epub ahead of print] PubMed PMID: 37697909
  • Waldman JC, Whitney GM, Twite MD, Ing RJ. Institutional-Specific Risk Stratification of Children With Congenital Heart Disease Undergoing Noncardiac Procedures. What are the Risks of Anesthesia at Your Institution?. J Cardiothorac Vasc Anesth. 2023 Sep;37(9):1723-1725. PubMed PMID: 37225548
  • Frank BS, Khailova L, Dekermanjian J, Mitchell MB, Morgan GJ, Twite M, Christians U, DiMaria MV, Klawitter J, Davidson JA. Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. 2023 Jan;2(1). PubMed PMID: 36875009
  • Stone ML, Albertz ML, Galambos C, Twite MD, Campbell DN, Di Maria M, Fonseca B, Miyamoto SD, Ing RJ. Multi-Disciplinary Management and Surgical Resection of Intracardiac Fibromas Causing Bilateral Ventricular Outflow Tract Obstructions in an Infant. Semin Cardiothorac Vasc Anesth. 2022 Aug 25;:10892532221123693. [Epub ahead of print] PubMed PMID: 36006828
  • Nasr VG, Staffa SJ, Vener DF, Huang S, Brown ML, Twite M, Miller-Hance WC, DiNardo JA. The Practice of Pediatric Cardiac Anesthesiology in the United States. Anesth Analg. 2022 Mar 1;134(3):532-539. PubMed PMID: 35180170
  • Nasr VG, Zabala L, Twite M. Expertise in Pediatric Cardiac Anesthesia Begins With Well-Designed Training Programs. J Cardiothorac Vasc Anesth. 2022 Mar;36(3):654-656. PubMed PMID: 34607761
  • Cooper DS, Hill KD, Krishnamurthy G, Sen S, Costello JM, Lehenbauer D, Twite M, James L, Mah KE, Taylor C, McBride ME. Acute Cardiac Care for Neonatal Heart Disease. Pediatrics. 2022 Nov 1;150(Suppl 2). PubMed PMID: 36317971
  • Nasr VG, Staffa SJ, Vener DF, Huang S, Brown ML, Twite M, Miller-Hance WC, DiNardo JA. The Practice of Pediatric Cardiac Anesthesiology in the United States. Anesth Analg. 2022 Mar 1;134(3):532-539. PubMed PMID: 35180170
  • Nasr VG, Zabala L, Twite M. Expertise in Pediatric Cardiac Anesthesia Begins With Well-Designed Training Programs. J Cardiothorac Vasc Anesth. 2022 Mar;36(3):654-656. PubMed PMID: 34607761
  • Nasr VG, Zabala L, Twite M. Expertise in Pediatric Cardiac Anesthesia Begins With Well-Designed Training Programs. J Cardiothorac Vasc Anesth. 2021 Sep 20. [Epub ahead of print] PubMed PMID: 34607761
  • Persson JN, Holstein J, Silveira L, Irons A, Rajab TK, Jaggers J, Twite MD, Scahill C, Kohn M, Gold C, Davidson JA. Validation of Point-of-Care Ultrasound to Measure Perioperative Edema in Infants With Congenital Heart Disease. Front Pediatr. 2021;9:727571. PubMed PMID: 34497787
  • Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 Oct;36(10):3259-3269. PubMed PMID: 33954809
  • Naresh NK, Malone L, Fujiwara T, Smith S, Lu Q, Twite MD, DiMaria MV, Fonseca BM, Browne LP, Barker AJ. Use of compressed sensing to reduce scan time and breath-holding for cardiac cine balanced steady-state free precession magnetic resonance imaging in children and young adults. Pediatr Radiol. 2021 Jun;51(7):1192-1201. PubMed PMID: 33566124
  • Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 Mar;229:24-37. PubMed PMID: 33045409
  • Houska N, Twite MD, Ing RJ. The Importance of the Airway in Children Undergoing Surgery for Congenital Heart Disease. J Cardiothorac Vasc Anesth. 2021 Jan;35(1):145-147. PubMed PMID: 33004270
  • Pulmonary Hypertension Twite M, Friesen R Chapter in Anesthesia for Congenital Heart Disease Editor Andropoulos
  • Message from the President Biannual Newsletter of the Congenital Cardiac Anesthesia Society
  • Persson JN, Holstein J, Silveira L, Irons A, Rajab TK, Jaggers J, Twite MD, Scahill C, Kohn M, Gold C, Davidson JA. Validation of Point-of-Care Ultrasound to Measure Perioperative Edema in Infants With Congenital Heart Disease. Front Pediatr. 2021;9:727571. PubMed PMID: 34497787
  • Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 Oct;36(10):3259-3269. PubMed PMID: 33954809
  • Naresh NK, Malone L, Fujiwara T, Smith S, Lu Q, Twite MD, DiMaria MV, Fonseca BM, Browne LP, Barker AJ. Use of compressed sensing to reduce scan time and breath-holding for cardiac cine balanced steady-state free precession magnetic resonance imaging in children and young adults. Pediatr Radiol. 2021 Jun;51(7):1192-1201. PubMed PMID: 33566124
  • Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 Mar;229:24-37. PubMed PMID: 33045409
  • Houska N, Twite MD, Ing RJ. The Importance of the Airway in Children Undergoing Surgery for Congenital Heart Disease. J Cardiothorac Vasc Anesth. 2021 Jan;35(1):145-147. PubMed PMID: 33004270
  • Vener DF, Abbasi RK, Brown M, Greene N, Guzzetta NA, Jacobs JP, Latham G, Mossad E, Nicolson SC, Twite M, Zhang S, Wise-Faberowski L. The Congenital Cardiac Anesthesia Society-Society of Thoracic Surgeons Cardiac Anesthesia Database Collaboration. World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):14-21. PubMed PMID: 31835986
  • Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2020 Oct 9. [Epub ahead of print] PubMed PMID: 33045409
  • Houska N, Twite MD, Ing RJ. The Importance of the Airway in Children Undergoing Surgery for Congenital Heart Disease. J Cardiothorac Vasc Anesth. 2020 Sep 10. [Epub ahead of print] PubMed PMID: 33004270
  • Sabapathy D, Klawitter J, Silveira L, Khailova L, Mitchell MB, Morgan GJ, DiMaria MV, Twite M, Frank BS, Davidson JA. Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics. 2020 Sep 5;16(9):93. PubMed PMID: 32889608
  • Ing RJ, Chatterjee D, Twite MD. Resuscitating Children with COVID-19: What the Pediatric Anesthesiologist Needs to Know. J Cardiothorac Vasc Anesth. 2020 Jun 16. [Epub ahead of print] PubMed PMID: 32624434
  • Faraoni D, Caplan LA, DiNardo JA, Guzzetta NA, Miller-Hance WC, Latham G, Momeni M, Nicolson SC, Spaeth JP, Taylor K, Twite M, Vener DF, Zabala L, Nasr VG. Considerations for Pediatric Heart Programs During COVID-19: Recommendations From the Congenital Cardiac Anesthesia Society. Anesth Analg. 2020 Aug;131(2):403-409. PubMed PMID: 32459667
  • Ing RJ, Barrett C, Chatterjee D, Twite M, Whitney GM. Perioperative Preparations for COVID-19: The Pediatric Cardiac Team Perspective. J Cardiothorac Vasc Anesth. 2020 Sep;34(9):2307-2311. PubMed PMID: 32451272
  • Ing RJ, Mclennan D, Twite MD, DiMaria M. Anesthetic Considerations for Fontan-Associated Liver Disease and the Failing Fontan Circuit. J Cardiothorac Vasc Anesth. 2020 Aug;34(8):2224-2233. PubMed PMID: 32249074
  • Vener DF, Abbasi RK, Brown M, Greene N, Guzzetta NA, Jacobs JP, Latham G, Mossad E, Nicolson SC, Twite M, Zhang S, Wise-Faberowski L. The Congenital Cardiac Anesthesia Society-Society of Thoracic Surgeons Cardiac Anesthesia Database Collaboration. World J Pediatr Congenit Heart Surg. 2020 Jan;11(1):14-21. PubMed PMID: 31835986
  • Del Rio JM, Twite M, Weitzel N, Kertai MD. Driving Paradigms Shifts Is at the Core of Our Specialty. Semin Cardiothorac Vasc Anesth. 2019 Dec;23(4):345-348. PubMed PMID: 31690256
  • Ing RJ, Twite M. The Year in Review: Anesthesia for Congenital Heart Disease 2018. Semin Cardiothorac Vasc Anesth. 2019 Jun;23(2):205-211. PubMed PMID: 31064317
  • Weitzel NS, Twite MD, Kertai MD. Knowledge of the Present Is the Roadmap for the Future. Semin Cardiothorac Vasc Anesth. 2019 Jun;23(2):145-147. PubMed PMID: 31064315
  • Twite MD, Stenquist S, Ing RJ. Williams syndrome. Paediatr Anaesth. 2019 May;29(5):483-490. PubMed PMID: 30811742
  • Ellis WC, Schafer M, Barrett CS, Butler K, Sprowell A, Twite M, Buckvold S, Jone PN, Ing RJ. Vascular anatomical considerations and clinical decision making during insertion of the Avalon(®) Elite Dual Lumen single-site veno-venous ECMO cannula in children weighing less than 20 kg. Perfusion. 2019 May;34(4):267-271. PubMed PMID: 30537888
  • Twite MD, Kertai MD, Weitzel N. Thomas Bevill Peacock and the First Descriptions of Congenital Heart Disease. Semin Cardiothorac Vasc Anesth. 2018 Sep;22(3):241-244. PubMed PMID: 30063197
  • Nasr VG, Twite MD, Walker SG, Kussman BD, Motta P, Mittnacht AJC, Mossad EB. Selected 2017 Highlights in Congenital Cardiac Anesthesia. J Cardiothorac Vasc Anesth. 2018 Aug;32(4):1546-1555. PubMed PMID: 29699846
  • Goot BH, Kaufman J, Pan Z, Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, Zuk J, da Cruz EM. Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery. Pediatr Crit Care Med. 2018 May;19(5):459-467. PubMed PMID: 29547456
  • Ing RJ, Twite MD. Toward Improved Neurodevelopmental Outcomes: The Role of Transfontanel Ultrasound Assessment of Cerebral Blood Flow in Infants Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2018 Aug;32(4):1655-1656. PubMed PMID: 29501227
  • Ing RJ, Twite MD. Noteworthy Literature published in 2017 for Congenital Cardiac Anesthesiologists. Semin Cardiothorac Vasc Anesth. 2018 Mar;22(1):35-48. PubMed PMID: 29400257
  • Ing RJ, Hoagland M, Mayes L, Twite M. The anesthetic management of button battery ingestion in children. Can J Anaesth. 2018 Mar;65(3):309-318. PubMed PMID: 29168156
  • Nasr VG, Guzzetta NA, Miller-Hance WC, Twite M, Latham GJ, Zabala L, Nicolson SC, Mossad EB, DiNardo JA. Consensus Statement by the Congenital Cardiac Anesthesia Society: Milestones for the Pediatric Cardiac Anesthesia Fellowship. Anesth Analg. 2018 Jan;126(1):198-207. PubMed PMID: 28922234
  • Nasr VG, Guzzetta NA, Miller-Hance WC, Twite M, Latham GJ, Zabala L, Nicolson SC, Mossad EB, DiNardo JA. Consensus Statement by the Congenital Cardiac Anesthesia Society: Milestones for the Pediatric Cardiac Anesthesia Fellowship. Anesth Analg. 2017 Sep 14. [Epub ahead of print] PubMed PMID: 28922234
  • Twite MD, Ing RJ, Nichols CS, Yaster M. Outstanding contribution to pediatric anesthesiology: An interview with Dr. Robert H. Friesen. Paediatr Anaesth. 2017 Oct;27(10):991-996. PubMed PMID: 28872749
  • Kertai MD, Twite MM, Weitzel N. Facing the Ever-Changing Challenges of Caring for Cardiothoracic and Transplant Surgery Patients. Semin Cardiothorac Vasc Anesth. 2017 Sep;21(3):197-199. PubMed PMID: 28758560
  • Fritock MD, Ing RJ, Twite MD. Cardiac Arrest in 2 Neonates Receiving Amiodarone and Dexmedetomidine. J Cardiothorac Vasc Anesth. 2017 Feb 21. [Epub ahead of print] PubMed PMID: 28550956
  • Twite MD. Sir William Harvey, Congenital Heart Disease and Anesthesia. Semin Cardiothorac Vasc Anesth. 2017 Jun;21(2):121-122. PubMed PMID: 28506196
  • Ing RJ, Twite M. Noteworthy Literature Published in 2016. Semin Cardiothorac Vasc Anesth. 2017 Mar;21(1):17-22. PubMed PMID: 28107799
  • Ing RJ, Kramer RE, Darst J, Mayes LM, Twite MD. Button battery ingestion in children: a role for angiography?. Can J Anaesth. 2017 Mar;64(3):321-322. PubMed PMID: 27804024
  • McRobb CM, Ing RJ, Lawson DS, Jaggers J, Twite M. Retrospective analysis of eliminating modified ultrafiltration after pediatric cardiopulmonary bypass. Perfusion. 2017 Mar;32(2):97-109. PubMed PMID: 27708000
  • Ing RJ, Kramer RE, Darst J, Mayes LM, Twite MD. Button battery ingestion in children: a role for angiography?. Can J Anaesth. 2016 Nov 1. [Epub ahead of print] PubMed PMID: 27804024
  • McRobb CM, Ing RJ, Lawson DS, Jaggers J, Twite M. Retrospective analysis of eliminating modified ultrafiltration after pediatric cardiopulmonary bypass. Perfusion. 2016 Oct 5. [Epub ahead of print] PubMed PMID: 27708000
  • Mann EE, Magin CM, Mettetal MR, May RM, Henry MM, DeLoid H, Prater J, Sullivan L, Thomas JG, Twite MD, Parker AE, Brennan AB, Reddy ST. Micropatterned Endotracheal Tubes Reduce Secretion-Related Lumen Occlusion. Ann Biomed Eng. 2016 Dec;44(12):3645-3654. PubMed PMID: 27535564
  • Davidson JA, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer PE, Klawitter J. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. PLoS One. 2016 Jul 6;11(7):e0158981. PubMed PMID: 27384524
  • Schwartz LI, Twite M, Gulack B, Hill K, Kim S, Vener DF. The Perioperative Use of Dexmedetomidine in Pediatric Patients with Congenital Heart Disease: An Analysis from the Congenital Cardiac Anesthesia Society-Society of Thoracic Surgeons Congenital Heart Disease Database. Anesth Analg. 2016 Sep;123(3):715-21. PubMed PMID: 27167685
  • Twite MD. Congenital Cardiac Forum. Semin Cardiothorac Vasc Anesth. 2016 Jun;20(2):119. PubMed PMID: 27146854
  • Twite M, Ing RJ. Noteworthy Literature in 2015: Anesthesia for Congenital Heart Disease. Semin Cardiothorac Vasc Anesth. 2016 Mar;20(1):14-23. PubMed PMID: 26783264
  • Schwartz LI, Miyamoto SD, Stenquist S, Twite MD. Cardiac Arrest in a Heart Transplant Patient Receiving Dexmedetomidine During Cardiac Catheterization. Semin Cardiothorac Vasc Anesth. 2016 Jun;20(2):175-8. PubMed PMID: 26721807
  • Friesen RH, Twite MD, Nichols CS, Cardwell KA, Pan Z, Darst JR, Wilson N, Fagan TE, Miyamoto SD, Ivy DD. Hemodynamic response to ketamine in children with pulmonary hypertension. Paediatr Anaesth. 2016 Jan;26(1):102-8. PubMed PMID: 26564806
  • Ing RJ, Twite MD. The year in review: anesthesia for congenital heart disease 2013. Semin Cardiothorac Vasc Anesth. 2014 Mar;18(1):17-23. PubMed PMID: 24623804
  • Twite MD, Friesen RH. The Anesthetic Management of Children with Pulmonary Hypertension in the Cardiac Catheterization Laboratory. Anesthesiol Clin. 2014 Mar;32(1):157-173. PubMed PMID: 24491655
  • Friesen RH, Twite MD. In response. Anesth Analg. 2014 Jul;119(1):217-8. PubMed PMID: 24945134
  • McRobb CM, Mejak BL, Ellis WC, Lawson DS, Twite MD. Recent Advances in Pediatric Cardiopulmonary Bypass. Semin Cardiothorac Vasc Anesth. 2014 May 29;18(2):153-160. [Epub ahead of print] PubMed PMID: 24876230
  • Gien J, Ing RJ, Twite MD, Campbell D, Mitchell M, Kinsella JP. Successful Surgical Management of Airway Perforation in Preterm Infants. J Pediatr Surg Case Rep. 2014 Feb 1;2(2):47-51. PubMed PMID: 24791225
  • Ing RJ, Twite MD. The year in review: anesthesia for congenital heart disease 2013. Semin Cardiothorac Vasc Anesth. 2014 Mar;18(1):17-23. PubMed PMID: 24623804
  • Twite MD, Friesen RH. The anesthetic management of children with pulmonary hypertension in the cardiac catheterization laboratory. Anesthesiol Clin. 2014 Mar;32(1):157-73. PubMed PMID: 24491655
  • Friesen RH, Nichols CS, Twite MD, Cardwell KA, Pan Z, Pietra B, Miyamoto SD, Auerbach SR, Darst JR, Ivy DD. The hemodynamic response to dexmedetomidine loading dose in children with and without pulmonary hypertension. Anesth Analg. 2013 Oct;117(4):953-9. PubMed PMID: 23960035
  • Mejak BL, Ing RJ, McRobb C, Ellis WC, Lawson DS, Twite MD, Jaggers J. Cryoprecipitate and platelet administration during modified ultrafiltration in children less than 10 kg undergoing cardiac surgery. J Extra Corpor Technol. 2013 Jun;45(2):107-11. PubMed PMID: 23930379
  • Kaufmnan J, Twite M, Barrett C, Peyton C, Koehler J, Rannie M, Kahn MG, Schofield S, Ing RJ, Jaggers J, Hyman D, da Cruz EM. A handoff protocol from the cardiovascular operating room to cardiac ICU is associated with improvements in care beyond the immediate postoperative period. Jt Comm J Qual Patient Saf. 2013 Jul;39(7):306-11. PubMed PMID: 23888640
  • Twite MD. Congenital cardiac forum: hypoplastic left heart syndrome. Semin Cardiothorac Vasc Anesth. 2013 Jun;17(2):90-1. PubMed PMID: 23649694
  • Twite M. Introducing the congenital cardiac forum. Semin Cardiothorac Vasc Anesth. 2013 Mar;17(1):7-8. PubMed PMID: 23423666
  • Twite MD, Ing RJ. Anesthetic considerations in infants with hypoplastic left heart syndrome. Semin Cardiothorac Vasc Anesth. 2013 Jun;17(2):137-45. PubMed PMID: 23416713
  • Singhal NR, Da Cruz EM, Nicolarsen J, Schwartz LI, Merritt GR, Barrett C, Twite MD, Ing RJ. Perioperative management of shock in two fontan patients with plastic bronchitis. Semin Cardiothorac Vasc Anesth. 2013 Mar;17(1):55-60. PubMed PMID: 23381614
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Anesthesiology, Board Certification (2013)
  • Anesthesiology, Board Certification (2007, 2018)
  • Pediatric Critical Care, Specialized Training (2003)
  • Pediatrics, International Certificate (1994)

General Information

Medical Schools:
  • MD, Royal College of Pediatrics and Child Health, UK (1998)
Residency Programs:
  • University of Colorado, Anesthesiology (2006)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Critical Care Medicine (2003)
Languages: English
Department: Anesthesiology-Pediatric Anesthesiology
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