Daniel Pastula, MD
Associate Professor, Neurology

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Medical School:
  • MD, Duke University School of Medicine (2009)
Graduate School :
  • MHS, Duke University (2008)
Undergraduate School:
  • ScB, Brown University (RI) (2003)
Internship:
  • University of California (San Francisco) Program (2010)
Residency:
  • University of California (San Francisco) Program, Chief Resident, Neurology (2013)
Languages: English
Department: Neurology

Professional Titles

  • Associate Professor, Neurology
  • Associate Professor of Neurology, Medicine (Infectious Diseases), and Epidemiology
  • Neuro-Infectious Diseases/Autoimmune Neurology Fellowship Director
  • Global Neurology Education Director
  • Affiliate Medical Epidemiologist
  • Consulting Medical Epidemiologist and Public Policy Advisor

Recognition & Awards

  • Health Equity Award, CDC (2020)
  • Executive Director Performance Award, CDPHE (2020)
  • CPR Excellence in International Emergency Response Award, CDC (2019)
  • Top Doctor in Neurology, 5280 Magazine (2018)
  • DSLR Excellence in International Emergency Response Award, CDC (2018)
  • Larry J. Anderson Award for Outstanding Public Health Science, CDC (2017)
  • NCEZID Excellence in International Emergency Response Award, CDC (2016)
  • Outstanding Unit Citation, U.S. Public Health Service (2015)
  • Presidential Unit Citation, U.S. Public Health Service (2015)
  • NCEZID EIS Outstanding Service Award, CDC (2015)

Research Interests

Neurohospitalist medicine, neuro-infectious diseases, public health, epidemiology, emerging infectious diseases, toxicology, cluster and outbreak investigations, emergency preparedness and response, public policy, environmental health, global health, and education

Teaching

  • Neuro-infectious Diseases/Autoimmune Neurology Fellowship Director (2015)
    School of Medicine, Neurology
  • Global Neurology Education Director (2019)
    School of Medicine, Neurology

Publications

  • Basile AJ, Horiuchi K, Goodman CH, Kosoy O, Panella AJ, Velez JO, Pastula DM, Brault AC, Staples JE, Calvert AE. Development of diagnostic microsphere-based immunoassays for Heartland virus. J Clin Virol. 2021 Jan;134:104693. PubMed PMID: 33248359
  • Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2020 Apr;26(2):149-154. PubMed PMID: 31858483
  • Macchi ZA, Kleinschmidt-DeMasters BK, Orjuela KD, Pastula DM, Piquet AL, Baca CB. Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature. J Neuroimmunol. 2020 Mar 7;342:577214. [Epub ahead of print] PubMed PMID: 32182452
  • Kapadia RK, Ney DE, Hannan M, Farley M, Pastula DM, Piquet AL. Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab. J Neuroimmunol. 2020 Jul 15;344:577259. PubMed PMID: 32416558
  • Staples JE, Pastula DM, Panella AJ, Rabe IB, Kosoy OI, Walker WL, Velez JO, Lambert AJ, Fischer M. Investigation of Heartland Virus Disease Throughout the United States, 2013-2017. Open Forum Infect Dis. 2020 May;7(5):ofaa125. PubMed PMID: 32478118
  • Kapadia RK, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Eastern Equine Encephalitis (EEE). Neurohospitalist. 2020 Jul;10(3):161-162. PubMed PMID: 32549937
  • Kapadia RK, Tyler KL, Pastula DM. Encephalitis in adults caused by herpes simplex virus. CMAJ. 2020 Aug 10;192(32):E919. PubMed PMID: 32778604
  • Venkatesan A, Chow FC, Aksamit A, Bartt R, Bleck TP, Jay C, Pastula DM, Roos KL, Rumbaugh J, Saylor D, Cho TA. Building a neuroinfectious disease consensus curriculum. Neurology. 2019 Jul 30;93(5):208-216. PubMed PMID: 31253643
  • Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
  • Ralston MSA, Murray MBP, Vela-Duarte D, Orjuela KD, Pastula DM. Neuroterrorism Preparedness for the Neurohospitalist. Neurohospitalist. 2019 Jul;9(3):151-159. PubMed PMID: 31244972
  • Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
  • Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
  • Sapkota S, Kobau R, Pastula DM, Zack MM. Close to 1 million US adults aged 55?years or older have active epilepsy-National Health Interview Survey, 2010, 2013, and 2015. Epilepsy Behav. 2018 Aug 2. [Epub ahead of print] PubMed PMID: 30078516
  • Carlson AL, Pastula DM, Lambert AJ, Staples JE, Muehlenbachs A, Turabelidze G, Eby CS, Keller J, Hess B, Buller RS, Storch GA, Byrnes K, Dehner L, Kirmani N, Kuhlmann FM. Heartland Virus and Hemophagocytic Lymphohistiocytosis in Immunocompromised Patient, Missouri, USA. Emerg Infect Dis. 2018 May;24(5):893-897. PubMed PMID: 29664369
  • Pessoa A, van der Linden V, Yeargin-Allsopp M, Carvalho MDCG, Ribeiro EM, Van Naarden Braun K, Durkin MS, Pastula DM, Moore JT, Moore CA. Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. Pediatrics. 2018 Feb;141(Suppl 2):S167-S179. PubMed PMID: 29437050
  • Ludt C, Leppert M, Jones A, Song J, Kuwayama D, Pastula DM, Poisson S. Multiple Strokes Associated With Elongation of the Hyoid Bone. Neurohospitalist. 2018 Jan;8(1):35-37. PubMed PMID: 29276562
  • Sapkota S, Kobau R, Pastula DM, Zack MM. People with epilepsy are diagnosed most often with unspecified epilepsy, followed by focal epilepsy, generalized convulsive epilepsy, and generalized nonconvulsive epilepsy-US MarketScan data, 2010-2015. Epilepsy Behav. 2018 Feb;79:244-246. PubMed PMID: 29249447
  • Beattie J, Parajuli S, Sanger M, Lee G, Pleninger P, Crowley G, Kwon S, Murthy V, Manko JA, Caplan A, Dufort E, Pastula DM, Nolan A. Zika Virus-Associated Guillain-Barré Syndrome in a Returning US Traveler. Infect Dis Clin Pract (Baltim Md). 2018 Nov;26(6):e80-e84. PubMed PMID: 30923438
  • McKay SL, Lee AD, Lopez AS, Nix WA, Dooling KL, Keaton AA, Spence-Davizon E, Herlihy R, Clark TA, Hopkins SE, Pastula DM, Sejvar J, Oberste MS, Pallansch MA, Patel M, Routh JA. Increase in Acute Flaccid Myelitis - United States, 2018. MMWR Morb Mortal Wkly Rep. 2018 Nov 16;67(45):1273-1275. PubMed PMID: 30439867
  • Salinas JL, Major CG, Pastula DM, Dirlikov E, Styczynski A, Luciano CA, Wojna V, Sharp TM, Sejvar JJ, Rivera-Garcia B. Incidence and clinical characteristics of Guillain-Barré syndrome before the introduction of Zika virus in Puerto Rico. J Neurol Sci. 2017 Jun 15;377:102-106. PubMed PMID: 28477675
  • Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun;26(3):457-463. PubMed PMID: 27995511
  • Tyler KL, Pastula DM. Hepatitis E Virus and Guillain-Barré Syndrome. JAMA Neurol. 2017 Jan 1;74(1):13-15. PubMed PMID: 27820625
  • Dirlikov E, Kniss K, Major C, Thomas D, Virgen CA, Mayshack M, Asher J, Mier-Y-Teran-Romero L, Salinas JL, Pastula DM, Sharp TM, Sejvar J, Johansson MA, Rivera-Garcia B. Guillain-Barré Syndrome and Healthcare Needs during Zika Virus Transmission, Puerto Rico, 2016. Emerg Infect Dis. 2017 Jan;23(1):134-136. PubMed PMID: 27779466
  • Hennessey MJ, Pastula DM, Machesky K, Fischer M, Lindsey NP, DiOrio M, Staples JE, de Fijter S. Investigation of Acute Flaccid Paralysis Reported with La Crosse Virus Infection, Ohio, USA, 2008-2014. Emerg Infect Dis. 2017 Dec;23(12):2075-2077. PubMed PMID: 29148398
  • McGuinness I, Beckham JD, Tyler KL, Pastula DM. An Overview of Yellow Fever Virus Disease. Neurohospitalist. 2017 Oct;7(4):157-158. PubMed PMID: 28974992
  • Pastula DM, Hancock WT, Bel M, Biggs H, Marfel M, Lanciotti R, Laven J, Chen TH, Staples JE, Fischer M, Hills SL. Chikungunya virus disease outbreak in Yap State, Federated States of Micronesia. PLoS Negl Trop Dis. 2017 Mar;11(3):e0005410. PubMed PMID: 28248978
  • Pastula DM, Yeargin-Allsopp M, Kobau R. Enhanced Epilepsy Surveillance and Awareness in the Age of Zika. JAMA Neurol. 2017 Jun 1;74(6):631-632. PubMed PMID: 28418503
  • Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep. 2017 Jan;19(1):4. PubMed PMID: 28220392
  • Pastula DM, Khan AS, Sharp TM, Biaukula VL, Naivalu TK, Rafai E, Ermias Belay, Staples JE, Fischer M, Kosoy OI, Laven JJ, Bennett EJ, Jenney AW, Naidu RN, Lanciotti RS, Galloway RL, Nilles EJ, Sejvar JJ, Kama M. Investigation of a Guillain-Barré syndrome cluster in the Republic of Fiji. J Neurol Sci. 2016 Sep 1. [Epub ahead of print] PubMed PMID: 27842986
  • Tyler KL, Pastula DM. Hepatitis E Virus and Guillain-Barré Syndrome. JAMA Neurol. 2016 Nov 7. [Epub ahead of print] PubMed PMID: 27820625
  • Garlick J, Lee TJ, Shepherd P, Linam WM, Pastula DM, Weinstein S, Schexnayder SM. Locally Acquired Eastern Equine Encephalitis Virus Disease, Arkansas, USA. Emerg Infect Dis. 2016 Dec;22(12):2216-2217. PubMed PMID: 27662563
  • Dirlikov E, Major CG, Mayshack M, Medina N, Matos D, Ryff KR, Torres-Aponte J, Alkis R, Munoz-Jordan J, Colon-Sanchez C, Salinas JL, Pastula DM, Garcia M, Segarra MO, Malave G, Thomas DL, Rodríguez-Vega GM, Luciano CA, Sejvar J, Sharp TM, Rivera-Garcia B. Guillain-Barré Syndrome During Ongoing Zika Virus Transmission - Puerto Rico, January 1-July 31, 2016. MMWR Morb Mortal Wkly Rep. 2016 Sep 2;65(34):910-4. PubMed PMID: 27584942
  • Aliabadi N, Messacar K, Pastula DM, Robinson CC, Leshem E, Sejvar JJ, Nix WA, Oberste MS, Feikin DR, Dominguez SR. Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014. Emerg Infect Dis. 2016 Aug;22(8):1387-94. PubMed PMID: 27434186
  • Sharp TM, Muñoz-Jordán J, Perez-Padilla J, Bello-Pagán MI, Rivera A, Pastula DM, Salinas JL, Martínez Mendez JH, Méndez M, Powers AM, Waterman S, Rivera-García B. Zika Virus Infection Associated With Severe Thrombocytopenia. Clin Infect Dis. 2016 Nov 1;63(9):1198-1201. PubMed PMID: 27418575
  • Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul;6(3):93-4. PubMed PMID: 27366289
  • Sejvar JJ, Lopez AS, Cortese MM, Leshem E, Pastula DM, Miller L, Glaser C, Kambhampati A, Shioda K, Aliabadi N, Fischer M, Gregoricus N, Lanciotti R, Nix WA, Sakthivel SK, Schmid DS, Seward JF, Tong S, Oberste MS, Pallansch M, Feikin D. Acute Flaccid Myelitis in the United States, August-December 2014: Results of Nationwide Surveillance. Clin Infect Dis. 2016 Sep 15;63(6):737-45. PubMed PMID: 27318332
  • Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Jun;22(3):257-60. PubMed PMID: 26903031
  • Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 1;73(7):875-9. PubMed PMID: 27183312
  • Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2016 Dec 19. [Epub ahead of print] PubMed PMID: 27995511
  • Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Pract. 2016 Dec;6(6):515-522. PubMed PMID: 28058206
  • Forrester JD, Kugeler KJ, Perea AE, Pastula DM, Mead PS. No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001-2010. Emerg Infect Dis. 2015 Nov;21(11):2036-9. PubMed PMID: 26488307
  • Pastula DM, Burish M, Reis GF, Bollen A, Cha S, Ralph J, Douglas VC. Adult-onset central nervous system hemophagocytic lymphohistiocytosis: a case report. BMC Neurol. 2015 Oct 14;15:203. PubMed PMID: 26467435
  • Kosoy OI, Lambert AJ, Hawkinson DJ, Pastula DM, Goldsmith CS, Hunt DC, Staples JE. Novel thogotovirus associated with febrile illness and death, United States, 2014. Emerg Infect Dis. 2015 May;21(5):760-4. PubMed PMID: 25899080
  • CDC, Children’s Hospital Colorado, CSTE. “Acute flaccid myelitis among persons aged =21 years—United States, August 1–November 13, 2014.” MMWR Morb Mortal Wkly Rep. 2015 Jan; 63(53):1243-4.
  • Pastula DM, Burish M, Reis GF, Bollen A, Cha S, Ralph J, Douglas VC. Adult-onset central nervous system hemophagocytic lymphohistiocytosis: a case report. BMC Neurol. 2015 Oct 14;15:203. PubMed PMID: 26467435
  • Pastula DM, Hoang Johnson DK, White JL, Dupuis AP 2nd, Fischer M, Staples JE. Jamestown Canyon Virus Disease in the United States-2000-2013. Am J Trop Med Hyg. 2015 Aug;93(2):384-9. PubMed PMID: 26033022
  • Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L. Acute neurologic illness of unknown etiology in children - Colorado, August-September 2014. MMWR Morb Mortal Wkly Rep. 2014 Oct 10;63(40):901-2. PubMed PMID: 25299607
  • Pastula DM, Turabelidze G, Yates KF, Jones TF, Lambert AJ, Panella AJ, Kosoy OI, Velez JO, Fisher M, Staples E. Notes from the field: Heartland virus disease - United States, 2012-2013. MMWR Morb Mortal Wkly Rep. 2014 Mar 28;63(12):270-1. PubMed PMID: 24670929
  • Pastula DM, Moore DH, Bedlack RS. Creatine for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev. 2012 Dec 12;12:CD005225. PubMed PMID: 23235621
  • Pastula DM, Coffman CJ, Allen KD, Oddone EZ, Kasarskis EJ, Lindquist JH, Morgenlander JC, Norman BB, Rozear MP, Sams LA, Sabet A, Bedlack RS. Factors associated with survival in the National Registry of Veterans with ALS. Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):332-8. PubMed PMID: 19922120
  • Bedlack RS, Pastula DM, Hawes J, Heydt D. Open-label pilot trial of levetiracetam for cramps and spasticity in patients with motor neuron disease. Amyotroph Lateral Scler. 2009 Aug;10(4):210-5. PubMed PMID: 18821142
  • Bedlack RS, Pastula DM, Welsh E, Pulley D, Cudkowicz ME. Scrutinizing enrollment in ALS clinical trials: room for improvement?. Amyotroph Lateral Scler. 2008 Oct;9(5):257-65. PubMed PMID: 18608092
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Professional Memberships

  • American Academy of Neurology, Member
  • CDC Epidemic Intelligence Service Alumni Association, Lifetime Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Neurology, Board Certification (2013)
  • CDC Epidemic Intelligence Service, Specialized Training (2015)
Conditions & Treatments
  • Brain and Nervous System
  • Infections
  • Brain and Nervous System - Stroke
  • Brain and Nervous System - Meningitis
  • Brain and Nervous System - Neurovascular Conditions
  • Poisoning, Toxicology, Environmental Health
  • Infections - Viral Infections
Clinical Interests
Neurohospitalist medicine and neuro-infectious diseases.

Public Speaking
Yes

General Information

Medical Schools:
  • MD, Duke University School of Medicine (2009)
Graduate Schools:
  • MHS, Duke University (2008)
Undergraduate Schools:
  • ScB, Brown University (RI) (2003)
Internships:
  • University of California (San Francisco) Program (2010)
Residency Programs:
  • University of California (San Francisco) Program, Chief Resident, Neurology (2013)
Download CV
Languages: English
Department: Neurology
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