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BK Kleinschmidt-DeMasters, MD
Professor, Pathology

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Medical School:
  • MD, University of Wisconsin School of Medicine and Public Health (1977)
Undergraduate School:
  • BS, Carroll College (MT) (1973)
Residencies:
  • University of Colorado, Pathology (1982)
  • University of Colorado, Pathology (1978)
Fellowships:
  • University of Colorado, Neuropathology (1983)
  • University of Kansas School of Medicine Program, Neuropathology (1985)
Languages: English
Department: Pathology

Professional Titles

  • Professor of Pathology, Neurology, and Neurosurgery
  • Head of Neuropathology

Recognition & Awards

  • Meritorious Service / Lifetime Achievement Award, American Association of Neuropathologists (2015)
  • Pathologist of the Year, UC-SOM (2012)
  • Top Doctor, 5280 Magazine (2012-2015) (2012)
  • Summit Award for Excellence in Teaching, UC-SOM (2010)
    2010 through 2014

Publications

  • 343. Gilani, A., Siddiq, Z., Kleinschmidt-Demasters, B.K. Temporal lobe myxoid glioneuronal tumor, PDGFRA p.K385L-mutant with DNA methylation confirmation. Brain Pathol. 2022 Sep;32(5):e13079 344. Kleinschmidt-Demasters, B.K., Marshall, CB. Thyroid metastases to the central nervous system and vertebrae. Folia Neuropathol. 2022;60(3):292-300 345. Monogue, B. Chen, Y., Sparks, H., Behbehani, R., Rajic, A., Massey, A., Kleinschmidt-Demasters, B.K., Kunath, T., Beckham, J.D. Alpha-synuclein supports type 1 interferon signaling in neurons. Brain. 2022 Oct 21;145(10):3622-3636 346. Kleinschmidt-DeMasters, B.K., Gilani A., Extra-CNS and dural metastases in FGFR3::TACC3 fusion-positive glioblastoma. Neuro oncology Practice, 2022 May 24;9(5):449-455 347. Cimino PJ, Ketchum C, Turakulov R, Singh O, Abdullaev Z, Giannini C, Pytel P, Lopez GY, Colman H, Nasrallah MP, Santi M, Fernandes IL, Nirschl J, Dahiya S, Neill S, Solomon D, Perez E, Capper D, Mani H, Caccamo D, Ball M, Badruddoja M, Chkheidze R, Camelo-Piragua S, Fullmer J, Alexandrescu S, Yeaney G, Eberhart C, Martinez-Lage M, Chen J, Zach L, Kleinschmidt-DeMasters BK, Hefti M, Lopes MB, Nuechterlein N, Horbinski C, Rodriguez FJ, Quezado M, Pratt D, Aldape K. Expanded analysis of high-grade astrocytoma with piloid features identifies and epigenetically and clinically distinct subtype associated with neurofibromatosis type 1. Acta Neuropathol. 2023 Jan;145(1):71-82 348. Gilani A, Kleinschmidt-DeMasters, B.K. Childhood small-vessel primary angiitis of the central nervous system: overlap with MOG-associated disease. Pediatr Dev Pathol., 2023 Jan-Feb;26(1):18-29 349. Kleinschmidt-DeMasters BK, Ormond DR. Leptomeningeal metastases and dural spread in adult high-grade astrocytomas, J Neuropathol Exp Neurol., 2023 Feb 21;82(3):194-201 350. Gilani A, Siddiq Z, Kissell E, Kasson J, Kleinschmidt-DeMasters, B.K. Genomic and epigenomic re-categorization of congenital glioblastoma and desmoplastic infantile ganglioglioma. Childs Nerv Syst. 2023 Jan 28. 351. Kleinschmidt-Demasters, B.K., Gilani, A. Some CNS sarcomas seen-a 22-year series. Clin Neuropathol. 2023 Mar-Apr;42(2):54-65 352. Guzman, S, Kleinschmidt-DeMasters, B.K. Urothelial carcinoma metastases impacting the CNS: a 20-year retrospective. Ann Diag Pathology 2023 Jan 27;64:152109. 353. Piantadosi, AL, Bombin A, Shariatzadeh, N, Arkun K, Alexandrescu, S, Kleinschmidt-DeMasters, Solomon IH, . Double stranded RNA immunohistochemistry as a screening tool for viral encephalitis. Am J Clin Pathol. 2023 Aug 1;160(2):210-219 354. Welton, T., George, NM., Ozbay, BN., Polese, AG., Osbore, G., Futia, GL., Kushner, JK., DeMasters, BK., Alexander, AL., Abosch, A., Ojemann, S., Restrepo, D., and Gibson, EA. Two-photon microendoscope for label-free 2 imaging in stereotactic neurosurgery. Biomed Opt Express. 2023 Jun 27;14(7):3705-3725 355. Shrestha, K., Kleinschmidt-DeMasters, B.K., Ormond, D.R., Diagnostic challenges of neurosarcoidosis in non-endemic areas, Frontier in Neurology, press 356. Kleinschmidt-DeMasters, B.K. Unusual features of neurosarcoidosis: an 18-year retrospective study. Ann Diag Pathol, Ann Diagn Pathol. 2023 Dec;67:152201 357. Gilani A, Kleinschmidt-DeMasters, B.K. Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism. Clin Neuropathol, in press 358. Guzman, S, Kleinschmidt-DeMasters, B.K. Rheumatoid arthritis for the neuropathologist: review of the literature. Brain Pathology, in preparation. 359. Lee, JC, Furtado, LV, Rose, G, Larkin, T, Sances, T, Kleinschmidt-DeMasters, BK, Bodmer, JL, Gokden, M, Bertrand, KC, Moreira, DC, GRobinson, GW, Ellison, D, Orr, BA Concurrent ependymal and ganglionic differentiation in a subset of Supratentorial Neuroepithelial Tumors with EWSR1-PLAGL1 rearrangement, in preparation
  • Willard N, Honce JM, Kleinschmidt-DeMasters BK. PRES: Review of Histological Features. J Neuropathol Exp Neurol. 2018 Feb 1;77(2):100-118. PubMed PMID: 29325172
  • Robinson C, Kleinschmidt-DeMasters BK. IDH1-Mutation in Diffuse Gliomas in Persons Age 55 Years and Over. J Neuropathol Exp Neurol. 2017 Jan 21. [Epub ahead of print] PubMed PMID: 28110298
  • Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 2017 Jan 17;6. PubMed PMID: 28094001
  • Carr SB, Kleinschmidt-DeMasters BK, Kerr JM, Kiseljak-Vassiliades K, Wierman ME, Lillehei KO. Negative surgical exploration in patients with Cushing's disease: benefit of two-thirds gland resection on remission rate and a review of the literature. J Neurosurg. 2017 Dec 8;:1-8. [Epub ahead of print] PubMed PMID: 29219752
  • Yang MJ, Whelan R, Madden J, Mulcahy Levy JM, Kleinschmidt-DeMasters BK, Hankinson TC, Foreman NK, Handler MH. Intracranial Ewing sarcoma: four pediatric examples. Childs Nerv Syst. 2017 Dec 28. [Epub ahead of print] PubMed PMID: 29285586
  • Pan Z, Kleinschmidt-DeMasters BK. CNS Erdheim-Chester Disease: A Challenge to Diagnose. J Neuropathol Exp Neurol. 2017 Dec 1;76(12):986-996. PubMed PMID: 29096034
  • Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA. Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression. Acta Neuropathol. 2017 Dec;134(6):961-963. PubMed PMID: 29063183
  • Korshunov A, Chavez L, Sharma T, Ryzhova M, Schrimpf D, Stichel D, Capper D, Sturm D, Kool M, Habel A, Kleinschmidt-DeMasters BK, Rosenblum M, Absalyamova O, Golanov A, Lichter P, Pfister SM, Jones DTW, Perry A, von Deimling A. Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis. Brain Pathol. 2017 Oct 9. [Epub ahead of print] PubMed PMID: 28990704
  • Donson AM, Apps J, Griesinger AM, Amani V, Witt DA, Anderson RCE, Niazi TN, Grant G, Souweidane M, Johnston JM, Jackson EM, Kleinschmidt-DeMasters BK, Handler MH, Tan AC, Gore L, Virasami A, Gonzalez-Meljem JM, Jacques TS, Martinez-Barbera JP, Foreman NK, Hankinson TC. Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma. J Neuropathol Exp Neurol. 2017 Sep 1;76(9):779-788. PubMed PMID: 28859336
  • Nunes RH, Hsu CC, da Rocha AJ, do Amaral LLF, Godoy LFS, Watkins TW, Marussi VH, Warmuth-Metz M, Alves HC, Goncalves FG, Kleinschmidt-DeMasters BK, Osborn AG. Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New "Leave Me Alone" Lesion with a Characteristic Imaging Pattern. AJNR Am J Neuroradiol. 2017 Oct;38(10):1899-1904. PubMed PMID: 28705817
  • Lummus SC, Donson AM, Gowan K, Jones KL, Vibhakar R, Foreman NK, Kleinschmidt-DeMasters BK. p16 Loss and E2F/cell cycle deregulation in infant posterior fossa ependymoma. Pediatr Blood Cancer. 2017 Dec;64(12). PubMed PMID: 28548702
  • Dahl NA, Luebbert T, Loi M, Neuberger I, Handler MH, Kleinschmidt-DeMasters BK, Mulcahy Levy JM. Chordoma Occurs in Young Children With Tuberous Sclerosis. J Neuropathol Exp Neurol. 2017 Jun 1;76(6):418-423. PubMed PMID: 28498973
  • Kleinschmidt-DeMasters BK, Donson A, Foreman NK, Dorris K. H3 K27M Mutation in Gangliogliomas can be Associated with Poor Prognosis. Brain Pathol. 2017 Nov;27(6):846-850. PubMed PMID: 28378357
  • Kiseljak-Vassiliades K, Mills TS, Zhang Y, Xu M, Lillehei KO, Kleinschmidt-DeMasters BK, Wierman ME. Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors. Endocrinology. 2017 May 1;158(5):1450-1460. PubMed PMID: 28323918
  • Kleinschmidt-DeMasters BK, Lillehei KO, Hankinson TC. Review of xanthomatous lesions of the sella. Brain Pathol. 2017 May;27(3):377-395. PubMed PMID: 28236350
  • Hankinson TC, Kleinschmidt-DeMasters BK. Adamantinomatous craniopharyngioma and xanthomatous lesions of the sella. Brain Pathol. 2017 May;27(3):356-357. PubMed PMID: 28236347
  • Robinson C, Kleinschmidt-DeMasters BK. IDH1-Mutation in Diffuse Gliomas in Persons Age 55 Years and Over. J Neuropathol Exp Neurol. 2017 Feb 1;76(2):151-154. PubMed PMID: 28110298
  • Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 2017 Jan 17;6. PubMed PMID: 28094001
  • Greer A, Foreman NK, Donson A, Davies KD, Kleinschmidt-DeMasters BK. Desmoplastic infantile astrocytoma/ganglioglioma with rare BRAF V600D mutation. Pediatr Blood Cancer. 2017 Jun;64(6). PubMed PMID: 27860162
  • Greer A, Foreman NK, Donson A, Davies KD, Kleinschmidt-DeMasters BK. Desmoplastic infantile astrocytoma/ganglioglioma with rare BRAF V600D mutation. Pediatr Blood Cancer. 2016 Nov 10. [Epub ahead of print] PubMed PMID: 27860162
  • Kleinschmidt-DeMasters BK. Histological features of pituitary adenomas and sellar region masses. Curr Opin Endocrinol Diabetes Obes. 2016 Dec;23(6):476-484. PubMed PMID: 27763894
  • Kleinschmidt-DeMasters BK, Lillehei KO. Radiation-Induced Cerebral Vascular "Malformations" at Biopsy. J Neuropathol Exp Neurol. 2016 Sep 30. [Epub ahead of print] PubMed PMID: 27694117
  • Nyberg E, Honce J, Kleinschmidt-DeMasters BK, Shukri B, Kreidler S, Nagae L. Arterial spin labeling: Pathologically proven superiority over conventional MRI for detection of high-grade glioma progression after treatment. Neuroradiol J. 2016 Oct;29(5):377-83. PubMed PMID: 27542895
  • Roberts S, Borges MT, Lillehei KO, Kleinschmidt-DeMasters BK. Double separate versus contiguous pituitary adenomas: MRI features and endocrinological follow up. Pituitary. 2016 Oct;19(5):472-81. PubMed PMID: 27209585
  • Ormond DR, Kleinschmidt-DeMasters BK. Diffuse astrocytoma arising within a demyelinating plaque. J Neurooncol. 2016 Jun;128(2):373-5. PubMed PMID: 27033061
  • Kleinschmidt-DeMasters BK, Donson AM, Richmond AM, Pekmezci M, Tihan T, Foreman NK. SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups. J Neuropathol Exp Neurol. 2016 Apr;75(4):295-8. PubMed PMID: 26945037
  • Greninger AL, Messacar K, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Nomura Y, Yagi S, Glaser C, Vollmer M, Press CA, Kleinschmidt-DeMasters BK, Dominguez SR, Chiu CY. Erratum to: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med. 2016 Jan 11;8(1):1. PubMed PMID: 26750923
  • Mann P, Kleinschmidt-DeMasters BK. CNS Masson Tumors: Frequent Association With Therapeutic Radiation. Am J Surg Pathol. 2016 Jan;40(1):81-93. PubMed PMID: 26492183
  • Shows J, Marshall C, Perry A, Kleinschmidt-DeMasters BK. Genetics of Glioblastomas in Rare Anatomical Locations: Spinal Cord and Optic Nerve. Brain Pathol. 2016 Jan;26(1):120-3. PubMed PMID: 26443345
  • Kleinschmidt-DeMasters BK, Aisner DL, Foreman NK. BRAF VE1 Immunoreactivity Patterns in Epithelioid Glioblastomas Positive for BRAF V600E Mutation. Am J Surg Pathol. 2015 Jan 9. [Epub ahead of print] PubMed PMID: 25581727
  • Kleinschmidt-DeMasters BK, Lopes MB, Prayson RA. An algorithmic approach to sellar region masses. Arch Pathol Lab Med. 2015 Mar;139(3):356-72. PubMed PMID: 25724033
  • Kiseljak-Vassiliades K, Xu M, Mills TS, Smith EE, Silveira LJ, Lillehei KO, Kerr JM, Kleinschmidt-DeMasters BK, Wierman ME. Differential somatostatin receptor (SSTR) 1-5 expression and downstream effectors in histologic subtypes of growth hormone pituitary tumors. Mol Cell Endocrinol. 2015 Dec 5;417:73-83. PubMed PMID: 26391562
  • Gump JM, Donson AM, Birks DK, Amani VM, Rao KK, Griesinger AM, Kleinschmidt-DeMasters BK, Johnston JM, Anderson RC, Rosenfeld A, Handler M, Gore L, Foreman N, Hankinson TC. Identification of targets for rational pharmacological therapy in childhood craniopharyngioma. Acta Neuropathol Commun. 2015 May 21;3:30. PubMed PMID: 25990246
  • Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015 Mar;29(3):460-72. PubMed PMID: 25650755
  • Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015 Mar;29(3):460-72. PubMed PMID: 25650755
  • Schowinsky JT, Ormond DR, Kleinschmidt-DeMasters BK. Tibial adamantinoma: late metastasis to the brain. J Neuropathol Exp Neurol. 2015 Jan;74(1):95-7. PubMed PMID: 25470349
  • Lummus SC, Aisner DL, Sams SB, Foreman NK, Lillehei KO, Kleinschmidt-DeMasters BK. Massive dissemination from spinal cord gangliogliomas negative for BRAF V600E: report of two rare adult cases. Am J Clin Pathol. 2014 Aug;142(2):254-60. PubMed PMID: 25015869
  • Ney DE, Carlson JA, Damek DM, Gaspar LE, Kavanagh BD, Kleinschmidt-DeMasters BK, Waziri AE, Lillehei KO, Reddy K, Chen C. Phase II trial of hypofractionated intensity-modulated radiation therapy combined with temozolomide and bevacizumab for patients with newly diagnosed glioblastoma. J Neurooncol. 2014 Dec 19. [Epub ahead of print] PubMed PMID: 25524817
  • Lummus S, Breeze R, Lucia MS, Kleinschmidt-DeMasters BK. Histopathologic features of intracranial vascular involvement in fibromuscular dysplasia, ehlers-danlos type IV, and neurofibromatosis I. J Neuropathol Exp Neurol. 2014 Oct;73(10):916-32. PubMed PMID: 25192048
  • Kiseljak-Vassiliades K, Carlson NE, Borges MT, Kleinschmidt-DeMasters BK, Lillehei KO, Kerr JM, Wierman ME. Growth hormone tumor histological subtypes predict response to surgical and medical therapy. Endocrine. 2014 Aug 17. [Epub ahead of print] PubMed PMID: 25129651
  • Kleinschmidt-DeMasters BK, West M. CLIPPERS with chronic small vessel damage: more overlap with small vessel vasculitis?. J Neuropathol Exp Neurol. 2014 Mar;73(3):262-7. PubMed PMID: 24487801
  • Lal A, Dahiya S, Gonzales M, Hiniker A, Prayson R, Kleinschmidt-DeMasters BK, Perry A. IgG4 overexpression is rare in meningiomas with a prominent inflammatory component: a review of 16 cases. Brain Pathol. 2014 Jul;24(4):352-9. PubMed PMID: 24467316
  • Wisell J, Kleinschmidt-DeMasters BK. Sox10 nuclear immunostaining lacks diagnostic utility for CNS granular cell tumors. J Neuropathol Exp Neurol. 2014 Jan;73(1):98-100. PubMed PMID: 24335528
  • Aisner DL, Newell KL, Pollack AG, Kleinschmidt-Demasters BK, Steinberg GK, Smyth LT, Vogel H. Composite pleomorphic xanthoastrocytoma-epithelioid glioneuronal tumor with BRAF V600E mutation - report of three cases. Clin Neuropathol. 2014 Mar-Apr;33(2):112-21. PubMed PMID: 24321241
  • Birlea M, Nagel MA, Khmeleva N, Choe A, Kleinschmidt-Demasters B, Hevner R, Boyer P, Lear-Kaul KC, Bos N, Wellish M, Cohrs RJ, Gilden D. Varicella-zoster virus trigeminal ganglioneuritis without rash. Neurology. 2014 Jan 7;82(1):90-2. PubMed PMID: 24285619
  • Donson AM, Kleinschmidt-DeMasters BK, Aisner DL, Bemis LT, Birks DK, Levy JM, Smith AA, Handler MH, Foreman NK, Rush SZ. Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases. Brain Pathol. 2014 Mar;24(2):173-83. PubMed PMID: 24238153
  • Lummus S, Kleinschmidt-DeMasters BK. Predominantly periventricular necrotizing encephalitis due to toxoplasmosis: two unusual cases and review of literature. Clin Neuropathol. 2014 Jan-Feb;33(1):29-37. PubMed PMID: 23993307
  • Kleinschmidt-DeMasters BK, Donson AM, Vogel H, Foreman NK. Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. Brain Pathol. 2014 Dec 17. [Epub ahead of print] PubMed PMID: 25521223
  • Dhaliwal JS, Seibold LK, Kleinschmidt-Demasters BK, Lillehei KO, Hink EM, Prall JA, Durairaj VD. Orbital invasion by ACTH-secreting pituitary adenomas. Ophthal Plast Reconstr Surg. 2014 Mar-Apr;30(2):e28-30. PubMed PMID: 23645353
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Professional Memberships

  • Society for Neuro-Oncology, Member
  • American Association for Cancer Research, Member
  • American Association of Neuropathologists, Member
  • American Association of Pathologists, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pathology, Board Certification (1982)
  • Neuropathology, Board Certification (1985)
Conditions & Treatments
  • Brain and Nervous System - Brain Tumors
  • Brain and Nervous System - Multiple Sclerosis
  • Brain and Nervous System - Pituitary Disorders
  • Cancers - Brain Cancer
  • Brain and Nervous System
  • Cancers

General Information

Medical Schools:
  • MD, University of Wisconsin School of Medicine and Public Health (1977)
Undergraduate Schools:
  • BS, Carroll College (MT) (1973)
Residency Programs:
  • University of Colorado, Pathology (1982)
  • University of Colorado, Pathology (1978)
Fellowships:
  • University of Colorado, Neuropathology (1983)
  • University of Kansas School of Medicine Program, Neuropathology (1985)
Languages: English
Department: Pathology
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